Path fall midterm GI two

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    Clostridium difficile colitis

    colon coated by tan pseudomembranes
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    Clostridium difficile colitis

    pattern of neutrophils emanating froma crypt, volcanic eruption
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    Clostridium diffcile colitis

    • Inc in elderly population
    • After normal flora wiped out by antibacterials
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    Crohn disease

    Small intestinal stricture
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    Chron disease

    Linear mucosal ulcers adn thickened intestinal wall
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    Crohn disease

    Perforation and associated serositis
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    Crohn diseas

    Creeping fat
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    Crohn disease

    Haphazard crypt organization resulting from repeated injury and regeneration
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    Crohn disease

    Noncaseating granuloma
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    Crohn disease

    Submucosal and serosal granulomas
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    Ulcerative collitis
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    Ulcerative colitis

    stops suddenly
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    Ulcerative Colitis

    Only mucosa involved
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    Ulcerative Colitis

    Crypt absess with neutrophils in lumen
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    Colitis associated dysplasia

    Dysplasia with extensive nuclear stratification and marked nuclear hyperchromasia
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    Ischemic bowel disease
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    Diverticular disease

    High pressure in intestines forms outpouches
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    Peutz-Jeghers Syndrome

    • Freckles around mouth
    • Also see polyps in small intestine (hemorrhagic) telescoping into bowel
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    Peutz-Jeghers polyp

    • Branching muscle strands
    • Distended glands without dysplasia
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    FAP polyps

    • thousands of polyps
    • familial adenomatous polyposis
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    Adenomatous Polyp
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    Adenomatous Polyp
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    Tubular adenoma with a smooth surface and rounded glands. Active inflammation is occasionally present in adenomas, in this case, crypt dilation and rupture can be seen at the bottom of the field
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    Villous adenoma with long, slender projections that are reminiscent of small intestinal villi
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    Dysplastic epithelial cells with an increased nuclear to cytoplasmic ratio, hyperchromatic and elongated nuclei and nuclear pseudostratification
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    Sessile serrated adenoma lined by goblet cells without typical cytologic features of dysplasia.
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    In-situ (non invasive) and invasive (basement membrane through) colorectal cancer
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    Colorectal cancer metastases in liver
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Path fall midterm GI two
part two of GI pics from review
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