Histology Photos

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    What is this? Where is it found? Function?
    Brown fat. Found in fetus and hibernating mammals. Temperature regulation. Multilocular.
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    What is this? Where is it found? Function?
    White fat. Found in adults. Used for energy storage, insulation, cushioning, some endocrine functions.
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    Basement membrane: Where is it found? Function? Components?
    • Basement membrane: basal lamina.
    • Made up of: collagen (mainly type IV), proteoglycans, multiadhesive glycoproteins (laminin, fibronectin).
    • It is a thin sheet of fiber that lines the epithelium.
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    Cornea. What is this showing? Function? Where else found?
    Dense, regular connective tissue. Abundant collagen fibers arranged in parallel. Also found in tendons, ligaments.
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    What is this? Where is it found? Function?
    • Dense irregular connective tissue. Abundant collagen fibers arranged irregularly.
    • Found in dermis of skin, submucosa of many organs, organ capsules.
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    What is this? Where is it found? Function?
    • Loose connective tissue.
    • More cells and ground substance, few fibers. Ground substance doesn't stain and appairs as white spaces.
    • Found in: lamina propria of tubular organs, surrounding vessels and nerves.
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    Elastic fibers. Where is it found? Function?
    • Part of elastic connective tissue.
    • Provides elasticity. Found in aorta and other places.
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    Elephant with tb LUNG. Where is seen here? Function?
    • Macrophages. Type of histiocyte and phagocyte.
    • Abundant eosinophilic cytoplasm. Round to oval euchromatic nucleus.
    • Two types: fixed and migratory. Lung: alveolar macrophages.
    • Fight infection.
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    What is this? Where is it found? Function?
    • Shown here are fibroblasts and the collagen they produce (stain blue with Masson's trichrome stain).
    • Heterochromatic nuclei.
    • Found in connective tissue.
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    Macrophages. Function?
    • Abundant eosinophilic cytoplasm with euchromatic nucleus.
    • Both fixed and migratory.
    • Phagocytes that fight infection.
  11. List fixed macrophages and where they are found.
    • •Brain
    • – Microglial or Gitter
    • cells
    • •Liver
    • – Kupffer
    • cells

    • •Lung
    • – Alveolar macrophages
    • •Kidney
    • – Mesangial cells
    • •Bone
    • - Osteoclasts
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    What is this? Where is it found? Function? Origin?
    • Found in skin and lung tissues, and near blood vessels within loose connective tissue.
    • Origin: bone marrow stem cell precursors.
    • Large, round cell with abundant cytoplasm and numerous cytoplasmic granules (containing histamine, heparin, and proteases)
    • Involved in inflammation and allergic reactions.
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    What is this? Where is it found? Function?
    • Plasma cell.
    • Antibody secreting cell, derived from stimulated B lymphocyte.
    • Common in lamina propria of GI and respiratory tracts.
    • Eccentric nucleus with mixture of euchromatin and heterochromatin.
    • Perinuclear clearning from poorly staining Golgi.
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    What is arrow pointing to?
    Plasma cell.
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    What is this? Function?
    • Neutrophil.
    • Primary acute inflammatory response cell. Ingests and kills bacteria.
    • Poorly staining granules.
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    What is this? Function?
    • Eosinophil.
    • Segmented heterochromatic nucleus.
    • Parasitic defense and some other immune reactions.
  17. What is Ehlers-Danlos syndrome?
    Genetic collagen disease. Characterized by increased skin elasticity and hypermotility of joints.
  18. Type I collagen
    Most common type (90% of vertebrate collagen). Tensile strenth of tissues.
  19. Type II Collagen
    Hyaline cartilage matrix.
  20. Type III Collagen
    Loose CT in organs. Fibrils thinner than Type I (reticular)
  21. Type IV Collagen
    • Basement membrane. Binds to laminin.
    • Non-fibrillar.
  22. Type VIII Collagen
    Descemet's membrane (cornea)
  23. Reticular fibers
    • Type 3 collagen.
    • Do not bundle into thick fibers. Arranged into loose mesh-like pattern.
    • Principle fiber in CT in lymph nodes, spleen, surrounding vessels and muscle cells.
  24. Hyalauronate
    • Nonsulfated, anionic GAG (glycosaminoglycans).
    • Widely distributed, constant component of ECM.
    • Forms in plasma membrane rather than Golgi.
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    What cells are shown? Where are they found? Function?
    • Transitional cells.
    • Function: barrier, distensible property.
    • Location: renal pelvis, ureters, bladder, proximal urethra.

    Allow the bladder to stretch.
  26. Simple squamous: functions, locations.
    • Functions: exchange, lubrication, barrier.
    • Locations:
    • Blood vessels & lymphatics (endothelium)
    • Endocardium
    • Body cavities (mesothelium)
    • Bowman’s capsule of renal glomerulus
    • Alveoli (lung)
  27. Simple cuboidal: Function, location.
    • Functions: barrier, conduit, absorption, secretion.
    • Locations: small exocrine gland ducts, kidney tubules, thyroid follicles, surface of ovary.
  28. Simple columnar: function, location
    • Functions: absorption, secretion.
    • Locations: small intestine, colon, stomach lining and gastric glands, and gallbladder.
  29. Stratified squamous: functions, locations
    • functions: barrier, protection
    • location: skin, oral cavity, esophagus, vagina, distal urethra.
  30. Stratified cuboidal: functions, locations
    • functions: barrier, conduit
    • locations: large ducts (sweat, salivary glands)
    • Junction b/n pseudostratified columnar and stratified squamous (urethra, anorectal junction).
  31. Stratified columnar: functions, locations
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    • F: protection, conduit, secretion.
    • L: large ducts of compound glands, conjunctive, transitional zones.
  32. Pseudostratified epitheliumImage Upload
    Single layer of cells sitting along the basement membrane. Not all the cells reach the free surface- look stratified.
  33. Pseudostratified (columnar): function, location
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    • F: secretion, absorption, conduit
    • L: tracheal, large bronchi, ductus deferens, efferent ductules of epididymis.
  34. Microvilli
    • Fingerlike cytoplasmic projections found on most epithelial cells.
    • Increase surface area.
    • Number correlates with
    • absorptive capacity.
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    • Made up of microvilli.
    • Gastrointestinal and renal epithelial cells.
    • May contain specific enzymes.
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    What is shown here?
    Steriocilia. Note how they aggregate into pointed bundles. Also found in the proximal ductus deferens and sensory (hair) cells of the ear.
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    Whats shown here?
    • Cilia. Short, fine, hair-like structures. Basal bodies anchor cilia.
    • Locations:
    • mucociliary clearance in air ways.
    • Oviducts=move ova and fluid toward uterus.
    • Sperm (flagellum)
  38. Structure of cilia
    • 9+2 structure. 9 microtubule doublets, 2 central microtubules.
    • Dynein arms: microtubule-associated motor protein.
    • Radial spokes.
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  39. Monocilia/Primary Cilia
    • Non-motile.
    • Specialized primary cilia that can be found in sensory organs (retina and nose)
    • 9+0 arrangement (lack central pair of microtubules and motor proteins)
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    • Role in embryonic development.
    • Mechanoreceptors that monitor fluid flow (kidney, pancreas, liver)
  40. 4 kinds of cell junctions
    • zonula occludens
    • zonula adherens (anchoring)
    • desmosome (anchoring)
    • communicating/gap junctions
  41. Anchoring junctions
    Zonula adherens, desmosome

    • Mechanical stability and structural integrity.
    • Cytoskeletal linkage between cells.
    • Cell to cell recognition.
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    What is this? Function? Adhesion molecules?
    • Zonula occludens (tight junction)
    • band goes around entire apical perimeter
    • limits movement of molecules through intercellular space
    • prevent movement of essential integral proteins.
    • Adhesion molecules: claudins, occludins.
  43. What is the matrix made up of?
    95% water, Type II collagen, GAGs, and proteoglycan aggregates.
  44. Types of cartilage?
    Hyaline, Elastic, Fibrous.
  45. What is cartilage made up of?
    • Water
    • Collagen, mostly type 2 (about 80%)
    • Proteoglycans: hyaluronan, chondroitin sulfate, and keratin sulfate.
    • Glycoproteins: fibronectin (the adhesion molecule that binds matrix proteins to chonrdocyte cell membranes) and chondronectin (facilitates proteoglycan binding to collagen fibers).
  46. Hyaline cartilage
    • Most abundant type in vertebrates.
    • Found in sites where ability to resist compression, and tensile strength, is required.
    • Remodels throughout life. Chondrocytes replace/degrade matrix and respond to environment.
    • All surfaces surrounded by perichondrium, except articular surface.
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  47. Image Upload
    What is this?
    Hyaline cartilage.
  48. Image Upload
    What is this?
    Elastic cartilage.
Card Set:
Histology Photos
2011-10-15 19:51:45
histology microscopy

Histology practice
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