Histology Photos

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Author:
lifesliaison
ID:
108878
Filename:
Histology Photos
Updated:
2011-10-15 15:51:45
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histology microscopy
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Histology practice
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  1. What is this? Where is it found? Function?
    Brown fat. Found in fetus and hibernating mammals. Temperature regulation. Multilocular.

  2. What is this? Where is it found? Function?
    White fat. Found in adults. Used for energy storage, insulation, cushioning, some endocrine functions.

  3. Basement membrane: Where is it found? Function? Components?
    • Basement membrane: basal lamina.
    • Made up of: collagen (mainly type IV), proteoglycans, multiadhesive glycoproteins (laminin, fibronectin).
    • It is a thin sheet of fiber that lines the epithelium.

  4. Cornea. What is this showing? Function? Where else found?
    Dense, regular connective tissue. Abundant collagen fibers arranged in parallel. Also found in tendons, ligaments.

  5. What is this? Where is it found? Function?
    • Dense irregular connective tissue. Abundant collagen fibers arranged irregularly.
    • Found in dermis of skin, submucosa of many organs, organ capsules.

  6. What is this? Where is it found? Function?
    • Loose connective tissue.
    • More cells and ground substance, few fibers. Ground substance doesn't stain and appairs as white spaces.
    • Found in: lamina propria of tubular organs, surrounding vessels and nerves.

  7. Elastic fibers. Where is it found? Function?
    • Part of elastic connective tissue.
    • Provides elasticity. Found in aorta and other places.

  8. Elephant with tb LUNG. Where is seen here? Function?
    • Macrophages. Type of histiocyte and phagocyte.
    • Abundant eosinophilic cytoplasm. Round to oval euchromatic nucleus.
    • Two types: fixed and migratory. Lung: alveolar macrophages.
    • Fight infection.

  9. What is this? Where is it found? Function?
    • Shown here are fibroblasts and the collagen they produce (stain blue with Masson's trichrome stain).
    • Heterochromatic nuclei.
    • Found in connective tissue.

  10. Macrophages. Function?
    • Abundant eosinophilic cytoplasm with euchromatic nucleus.
    • Both fixed and migratory.
    • Phagocytes that fight infection.
  11. List fixed macrophages and where they are found.
    • •Brain
    • – Microglial or Gitter
    • cells
    • •Liver
    • – Kupffer
    • cells

    • •Lung
    • – Alveolar macrophages
    • •Kidney
    • – Mesangial cells
    • •Bone
    • - Osteoclasts

  12. What is this? Where is it found? Function? Origin?
    • Found in skin and lung tissues, and near blood vessels within loose connective tissue.
    • Origin: bone marrow stem cell precursors.
    • Large, round cell with abundant cytoplasm and numerous cytoplasmic granules (containing histamine, heparin, and proteases)
    • Involved in inflammation and allergic reactions.

  13. What is this? Where is it found? Function?
    • Plasma cell.
    • Antibody secreting cell, derived from stimulated B lymphocyte.
    • Common in lamina propria of GI and respiratory tracts.
    • Eccentric nucleus with mixture of euchromatin and heterochromatin.
    • Perinuclear clearning from poorly staining Golgi.

  14. What is arrow pointing to?
    Plasma cell.

  15. What is this? Function?
    • Neutrophil.
    • Primary acute inflammatory response cell. Ingests and kills bacteria.
    • Poorly staining granules.

  16. What is this? Function?
    • Eosinophil.
    • Segmented heterochromatic nucleus.
    • Parasitic defense and some other immune reactions.
  17. What is Ehlers-Danlos syndrome?
    Genetic collagen disease. Characterized by increased skin elasticity and hypermotility of joints.
  18. Type I collagen
    Most common type (90% of vertebrate collagen). Tensile strenth of tissues.
  19. Type II Collagen
    Hyaline cartilage matrix.
  20. Type III Collagen
    Loose CT in organs. Fibrils thinner than Type I (reticular)
  21. Type IV Collagen
    • Basement membrane. Binds to laminin.
    • Non-fibrillar.
  22. Type VIII Collagen
    Descemet's membrane (cornea)
  23. Reticular fibers
    • Type 3 collagen.
    • Do not bundle into thick fibers. Arranged into loose mesh-like pattern.
    • Principle fiber in CT in lymph nodes, spleen, surrounding vessels and muscle cells.
  24. Hyalauronate
    • Nonsulfated, anionic GAG (glycosaminoglycans).
    • Widely distributed, constant component of ECM.
    • Forms in plasma membrane rather than Golgi.

  25. What cells are shown? Where are they found? Function?
    • Transitional cells.
    • Function: barrier, distensible property.
    • Location: renal pelvis, ureters, bladder, proximal urethra.

    Allow the bladder to stretch.
  26. Simple squamous: functions, locations.
    • Functions: exchange, lubrication, barrier.
    • Locations:
    • Blood vessels & lymphatics (endothelium)
    • Endocardium
    • Body cavities (mesothelium)
    • Bowman’s capsule of renal glomerulus
    • Alveoli (lung)
  27. Simple cuboidal: Function, location.
    • Functions: barrier, conduit, absorption, secretion.
    • Locations: small exocrine gland ducts, kidney tubules, thyroid follicles, surface of ovary.
  28. Simple columnar: function, location
    • Functions: absorption, secretion.
    • Locations: small intestine, colon, stomach lining and gastric glands, and gallbladder.
  29. Stratified squamous: functions, locations
    • functions: barrier, protection
    • location: skin, oral cavity, esophagus, vagina, distal urethra.
  30. Stratified cuboidal: functions, locations
    • functions: barrier, conduit
    • locations: large ducts (sweat, salivary glands)
    • Junction b/n pseudostratified columnar and stratified squamous (urethra, anorectal junction).
  31. Stratified columnar: functions, locations
    • F: protection, conduit, secretion.
    • L: large ducts of compound glands, conjunctive, transitional zones.
  32. Pseudostratified epithelium
    Single layer of cells sitting along the basement membrane. Not all the cells reach the free surface- look stratified.
  33. Pseudostratified (columnar): function, location
    • F: secretion, absorption, conduit
    • L: tracheal, large bronchi, ductus deferens, efferent ductules of epididymis.
  34. Microvilli
    • Fingerlike cytoplasmic projections found on most epithelial cells.
    • Increase surface area.
    • Number correlates with
    • absorptive capacity.
    • Made up of microvilli.
    • Gastrointestinal and renal epithelial cells.
    • May contain specific enzymes.

  35. What is shown here?
    Steriocilia. Note how they aggregate into pointed bundles. Also found in the proximal ductus deferens and sensory (hair) cells of the ear.

  36. Whats shown here?
    • Cilia. Short, fine, hair-like structures. Basal bodies anchor cilia.
    • Locations:
    • mucociliary clearance in air ways.
    • Oviducts=move ova and fluid toward uterus.
    • Sperm (flagellum)
  37. Structure of cilia
    • 9+2 structure. 9 microtubule doublets, 2 central microtubules.
    • Dynein arms: microtubule-associated motor protein.
    • Radial spokes.
  38. Monocilia/Primary Cilia
    • Non-motile.
    • Specialized primary cilia that can be found in sensory organs (retina and nose)
    • 9+0 arrangement (lack central pair of microtubules and motor proteins)
    • Role in embryonic development.
    • Mechanoreceptors that monitor fluid flow (kidney, pancreas, liver)
  39. 4 kinds of cell junctions
    • zonula occludens
    • zonula adherens (anchoring)
    • desmosome (anchoring)
    • communicating/gap junctions
  40. Anchoring junctions
    Zonula adherens, desmosome

    • Mechanical stability and structural integrity.
    • Cytoskeletal linkage between cells.
    • Cell to cell recognition.

  41. What is this? Function? Adhesion molecules?
    • Zonula occludens (tight junction)
    • band goes around entire apical perimeter
    • limits movement of molecules through intercellular space
    • prevent movement of essential integral proteins.
    • Adhesion molecules: claudins, occludins.
  42. What is the matrix made up of?
    95% water, Type II collagen, GAGs, and proteoglycan aggregates.
  43. Types of cartilage?
    Hyaline, Elastic, Fibrous.
  44. What is cartilage made up of?
    • Water
    • Collagen, mostly type 2 (about 80%)
    • Proteoglycans: hyaluronan, chondroitin sulfate, and keratin sulfate.
    • Glycoproteins: fibronectin (the adhesion molecule that binds matrix proteins to chonrdocyte cell membranes) and chondronectin (facilitates proteoglycan binding to collagen fibers).
  45. Hyaline cartilage
    • Most abundant type in vertebrates.
    • Found in sites where ability to resist compression, and tensile strength, is required.
    • Remodels throughout life. Chondrocytes replace/degrade matrix and respond to environment.
    • All surfaces surrounded by perichondrium, except articular surface.

  46. What is this?
    Hyaline cartilage.

  47. What is this?
    Elastic cartilage.

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