Pharm 3 drugs

Card Set Information

Author:
ldewanz
ID:
109124
Filename:
Pharm 3 drugs
Updated:
2011-10-17 21:49:59
Tags:
pharm drugs
Folders:

Description:
drugs for pharm exam 3
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user ldewanz on FreezingBlue Flashcards. What would you like to do?


  1. Esomeprazole
    • proton pump inhib
    • Mech: irreversably modify active site/require activation
    • dose daily/half life 2 hr/2-5 days to work
    • geletin capsule to be absorbed into blood
    • Excretion: liver (CYP drug interaction)
    • few side effects (GI ones)
  2. Lansoprazole
    • proton pump inhib
    • Mech: irreversably modify active site/require activation
    • dose daily/half life 2 hr/2-5 days to work
    • geletin capsule to be absorbed into blood
    • Excretion: liver (CYP drug interaction)
    • few side effects (GI ones)
  3. Omeprazole
    • proton pump inhib
    • Mech: irreversably modify active site/require activation
    • dose daily/half life 2 hr/2-5 days to work
    • geletin capsule to be absorbed into blood
    • Excretion: liver (CYP drug interaction)
    • few side effects (GI ones)
  4. Cimetidine
    • H2 receptor antagonist
    • Mech: Blk base level maintained by ECL cells
    • Mech: Dec pepsin/intrinsic factor
    • Use: Nocturnal acid/Zollinger-Ellison syndrome/ duodenal ulcers
    • Excretion: Renal
    • Half life: short
    • long term use=galactorrhea/dec sperm/gynecomastia
  5. Ranitidine
    • H2 receptor antagonist
    • Mech: Blk base level maintained by ECL cells
    • Mech: Dec pepsin/intrinsic factor
    • Use: Nocturnal acid/Zollinger-Ellison syndrome/duodenal ulcers
    • Excretion: Renal
    • Half life: Med
  6. Famotidine
    • H2 receptor antagonist
    • Mech: Blk base level maintained by ECL cells
    • Mech: Dec pepsin/intrinsic factor
    • Use: Nocturnal acid/Zollinger-Ellison syndrome/ duodenal ulcers
    • Excretion: Renal
    • Half life: Long
  7. Sucralfate
    • Misc. agent
    • Mech: forms sticky neutral pH coating that covers epithelium
    • For stress ulcers (better for duodenal)
    • Acid activated (avoid antacids/PPI)
    • Side effect: constipation (blks absorption of other drugs)
  8. Aluminum Hydroxide
    • Neutralizing antacids
    • slower acting than Mg (combo works best)
    • Mech: delays emptying/slows motility
    • Side effects: constipation
  9. Calcium Carbonate
    • Neutralizing antacids
    • Combo works best
  10. Magnesium hydroxide
    • Neutralizing antacids/Osmotic cathartic/laxative @ lower dose
    • Faster acting than Al (combo is best)
    • Mech: stimulates gastric emptying/motility/water retention/stimulate CCKto inc motility
    • Use: stool hardness
    • Contra: renal disease/cardiac disease/electrolyte imbalance/diuretics
  11. Magnesium trisilicate
    • Neutralizing antacids
    • Faster acting than Al (combo works best)
    • Mech: stimulates gastric emptying/motility
    • Side effects: silica absorbed and forms renal stones
    • Contra: renal disease
  12. Misoprostol
    • Prostaglandin analog
    • Mech: dec basal/food-induced acid production
    • Half life: short (freq dosage)
    • Use: only NSAID injury
    • Side effects: IBD/inc uterine contractions/diarrhea
  13. Pirenzepine
    • M1 antagonist
    • Least efficacious
    • Mech: Blks NT=less stiumulation of parietal/ECL cells
    • Side effects: anticholinergic
  14. Bethanechol
    • Prokinetic agent
    • Mech: activate M2/M3
    • Use: bladder/urination stimulation post-surgery
    • Side effects: flushing/bradycardia/salivation/cramps
  15. Cisapride
    • Prokinetic agent
    • Mech: 5-HT4 receptor agonist (intrinsic sensory neurons) and adenylate cyclase stimulant
    • Use: GERD
    • Side effects: fatal cardia arrhythmia (2nd line)
  16. Erthromycin
    • Prokinetic agent
    • Mech: motilin agonist/inc perastalsis
    • Use: macrolide antibiotics/ileus/pseudo-obstructions
    • Side effects: painful (NOT chronic use)
  17. Metoclopramide
    • Prokinetic agent
    • Mech: Dopamine receptor antagonist (inc ACh)
    • Use: Inc LES tone/upper GI motility/antiemetic/ laxitive
    • Side effects: extrapyramidal/dystonia/tardive dyskenesia
  18. Neostigmine
    • Prokinetic agent
    • Mech: AChE inhibitor
    • Use: Ileus
  19. Tegaserod
    • Prokinetic agent
    • Mech: seratonin partial agonist
    • Use: femlae IBS/improve lower bowel motility
  20. Magnesium citrate
    • Osmotic cathartic/laxative @ lower dose
    • Non-absorbable agent
    • Mech: water retention/stimulate CCK receptors/inc motility
    • Contra: renal/cardic/electrolyte imbal/diuretics
  21. Magnesium Sulfate
    • Osmotic cathartic/laxative @ lower dose
    • Non-absorbable agent
    • Mech: water retention/stimulate CCK receptors/inc motility
    • Contra: renal/cardic/electrolyte imbal/diuretics
  22. Polyethylene glycol
    • Osmotic cathartic/laxative @ lower dose
    • Non-absorbable agent (alcohol)
    • Mech: water retention
  23. Lactulose
    • Osmotic cathartic/laxative @ lower dose
    • Non-absorbable agent
    • Mech: water retention
    • Use: constipation from opioids/vincristine
    • fermentation drops pH/trap amonia
  24. Mannitol
    • Osmotic cathartic/laxative @ lower dose
    • Non-absorbable agent
    • Mech: water retention
    • Use: constipation from opioids/vincristine
  25. Sorbitol
    • Osmotic cathartic/laxative @ lower dose
    • Non-absorbable agent
    • Mech: water retention
    • Use: constipation from opioids/vincristine
  26. Ducusate
    • Stool wetting agent
    • Mech: surfactant/mix fatty substances and water
    • Use: stool softener
  27. Bisacodyl
    • irritant laxative
    • oral/rectal
    • NO chew or milk to have reach action in sm. intestine and avoid gastric irritation
  28. castor oil
    • irritant laxative
    • Mech: smooth muscle stimulant
    • Use: laxative/cathartic/induce labor
  29. Glycerin
    • irritant laxative
    • Mech: inc water retention/stim peristalsis/evacuation reflex
    • suppository
  30. Methylcellulose
    • bulk-forming laxative
    • Mech: fiber base
    • Use: regular soft stool
    • Contra: obstructions/may absorb drugs
  31. polycarbophil
    • bulk-forming laxative
    • Mech: fiber base
    • Use: regular soft stool
    • Contra: obstructions/may absorb drugs
  32. psyllium
    • bulk-forming laxative
    • Mech: fiber base
    • Use: regular soft stool
    • Contra: obstructions/may absorb drugs
  33. Busmuth subsalicylate
    • Antidiarrheal agent
    • Mech: salicylate absorbed systemically from stomach
  34. Diphenoxylate
    • Antidiarrheal agent
    • Mech: Opioid
    • Side effects: CNS
  35. Loperamide
    • Antidiarrheal agent
    • Mech: Opioid receptor agonist agonist stop motility
    • Side effects: No CNS
  36. Octreotide
    • Antidiarrheal agent
    • Use: post-surgical gastric dumping syndrome/chemo/ rest pancreatitis
    • Side effects: nausea/bloating/gallstones
  37. Chlorpromazine
    • Antiemetic
    • general purpose anti-nausea/anti-emetics
    • Mech: D2 receptor in CTZ/H1 receptor
    • Use: motion sickness
  38. Cyclizine
    • Antiemetic
    • antihistamines
    • Mech: H1 receptor antagonist//brainstem/vestibular apparatus/anticholinergic for abdo CA
    • Use: motion sickness/post-op emesis
  39. Diphenhydramine
    • Antiemetic
    • antihistamines
    • Mech: H1 receptor antagonist//brainstem/vestibular apparatus
    • Use: motion sickness/post-op emesis
  40. dimenhydrinate
    • Antiemetic
    • a salt of diphenhydramine and chlorotheophyllinate
  41. dolasetron
    • Antiemetic
    • Seratonin receptor antagonist
    • Mech: CTZ/STN/sm intestine
    • Use: chemo induced effects
    • Elimination: kidney
    • Side effects: constipation/diarrhea/HA/light-headed
  42. Hydroxyzine
    • Antiemetic
    • antihistamines
    • Mech: H1 receptor antagonist//brainstem/vestibular apparatus
    • Use: motion sickness/post-op emesis
  43. granisetron
    • Antiemetic
    • Seratonin receptor antagonist
    • Mech: CTZ/STN/sm intestine
    • Use: chemo induced effects
    • Elimination: kidney
    • Side effects: constipation/diarrhea/HA/light-headed
  44. metoclopramide
    • Antiemetic
    • Dopamine receptor antagonist
    • Mech: CTZ/inc forward motility/promotes defecation
    • Use: chemo nausea
    • Side effects: Parkinsonian/extrapyramidal/dissociative dysphoria
  45. odansetron
    • Antiemetic
    • Seratonin receptor antagonist
    • Mech: CTZ/STN/sm intestine
    • Use: chemo induced effects
    • Elimination: kidney
    • Side effects: constipation/diarrhea/HA/light-headed
  46. palonosetron
    • Antiemetic
    • Seratonin receptor antagonist
    • Mech: CTZ/STN/sm intestine
    • Use: chemo induced effects
    • Elimination: kidneySide effects: constipation/diarrhea/HA/light-headed
  47. prochlorperazine
    • Antiemetic
    • general purpose anti-nausea/anti-emetics
    • Mech: D2 receptor in CTZ/H1 receptor
    • Use: motion sickness
  48. promethazine
    • Antiemetic
    • antihistamines
    • Mech: H1 receptor antagonist//brainstem/vestibular apparatus
    • Use: motion sickness/post-op emesis
  49. scopolamine
    • Antiemetic
    • Mech: Ach receptor antagonist/vestibular apparatus
    • Use: motion sickness/post-op emesis
    • Side effects: dry mouth/blurred vision/uncontrolled behavior
  50. apomorphine
    • emetic agent
    • Mech: CTZ/sub-Q
  51. 6-mercaptopurine
    • bowel disease
    • Mech: immunosuppressive
    • Use: maintain remission in UC and Chron's/tx fistulas in chrons
    • Side effects: nausea vomiting/bone marrow suppression
  52. adalimumab
    • bowel disease
    • Anti-TNF antibody
    • Mech: interfere imflammatory response/human Ab
    • Use: maintain remission UC and Chron's
    • Side effects: inc resp infections/lack response to TB
  53. alosetron
    • bowel disease
    • Mech: 5-HT3 antagonist
    • Use: diarrhea predominant UBS
  54. azathioprine
    • bowel disease
    • Mech: immunosuppressive
    • Use: maintain remission in UC and Chron's/tx fistulas in chrons
    • Side effects: nausea vomiting/bone marrow suppression
  55. budesonide
    • bowel disease
    • Glucocorticoid
    • Mech: immune response/more potent but high 1st pass/topical inside bowel
    • Use: acute exacerbation/severe disease
    • Side effects: immunosuppression/endocrine/steroid psychoses
  56. infliximab
    • bowel disease
    • Anti-TNF antibody
    • Mech: interferes inflammatory response/humanized Ab
    • Use: maintain remission UC and Chron's
    • Side effects: inc resp infections/lack response to TB
  57. mesalamine
    • bowel disease
    • 5-ASA therapy
    • Mech: inhib TNFa/pH sensitive capsule activated in ileum
    • Use: flare ups of UC and Chron's
    • side effects: diarrhea
  58. olsalazine
    • bowel disease
    • 5-ASA therapy
    • Mech: inhib TNFa/activated in colon/
    • Use: flare ups of UC and Chron's
    • side effects: diarrhea
  59. prednisone
    • bowel disease
    • Glucocorticoid
    • Mech: immune response
    • Use: acute exacerbation/severe disease
    • Side effects: immunosuppression/endocrine/steroid psychoses
  60. sulfasalazine
    • bowel disease
    • 5-ASA therapy
    • Mech: inhib TNFa/activated in colon/
    • Use: flare ups of UC and Chron's
    • Side effects: allergic rxn/HA/nausea/fatigue
    • Contra: preg
  61. Ipecac
    • emetic agent
    • Mech: oral/CTZ
    • Contra: danger of choking
  62. Heparin Sulfate
    • Anticoagulant
    • Mech: inhib Xa and IXa and thrombin when bound to ATIII
    • Side effect: bleeding/thrombocytopenia/hyperkalemia/ osteoporosis
  63. Protamine sulfate
    Heparin antagonist
  64. Warfarin
    • Anticoagulant
    • Mech: antagonized Vit K dependent famma-carboxylation of factor II/VII/IX/X
    • Elimination: kidney/liver (if failure red dose)
    • Side effects: bleeding (w/NSAIDS)
    • Contra: preg (teratogenic)
    • **many drug interaction**
  65. Menadione
    warfarin antidote
  66. Dalteparin
    low molecular weight heparin
  67. enoxaparin
    low molecular weight heparin
  68. fondaparinux
    low molecular weight heparin
  69. Argatroban
    • direct thrombin inhibitor
    • Use: short acting
    • Elimination: hepatic
  70. bivalirudin
    direct thrombin inhibitor
  71. Dabigatran etexilate
    • direct thrombin inhibitor
    • oral
  72. lepirudin
    • direct thrombin inhibitor
    • Use: anticoagulant in heparin-induced thrombocytopenia
    • Elimination: renal
  73. Tissue plasminogen activator
    • thrombolytic
    • Half: short given as continuous infusion (met by liver)
  74. streptokinase
    • thrombolytic
    • Mech: forms complex with plasminogen/must overcome neutralizing antibodies
    • Side effects: anaphylaxis/fever
    • **only 1 time use**
  75. urokinase
    • thrombolytic
    • Half: med (met by liver)
    • **multiple time use**
  76. Abciximab
    • antiplatelet drug
    • Mech: gylcoprotein IIb/IIIa inhib/human-mouse monoclonal antibody
  77. Aspirin
    • antiplatelet drug
    • irreversable inhibition
  78. clopidogrel
    • antiplatelet drug
    • Mech: inhib platelt fxn by binding platelet G-protein receptors
    • Side effects: thrombotic thrombocytopenia purpura
  79. ticlopidine
    • antiplatelet drug
    • Mech: binds to G-protein coupled platelet receptors/ inhib platelet fxn
    • Use: CVD
    • Side effects: neutropenia (1%)
  80. tirofiban
    • antiplatelet drug
    • Mech: Glycoprotein IIb/IIIa inhib/inhib fibrinogen binding
  81. Candesartan
    • AT1 antagonist/ARB
    • Mech: competative AT1 antagonist/residual AT2 activation
    • Side effects: hypotension/hyperkalemia/renal failure
    • Contra: preg/nursing mothers
  82. Irbesartan
    • AT1 antagonist/ARB
    • Mech: competative AT1 antagonist/residual AT2 activation
    • Side effects: hypotension/hyperkalemia/renal failure
    • Contra: preg/nursing mothers
  83. Losartan
    • AT1 antagonist/ARB
    • Mech: competative AT1 antagonist/residual AT2 activation
    • Side effects: hypotension/hyperkalemia/renal failure
    • Contra: preg/nursing mothers
  84. Valsartan
    • AT1 antagonist/ARB
    • Mech: competative AT1 antagonist/residual AT2 activation
    • Side effects: hypotension/hyperkalemia/renal failure
    • Contra: preg/nursing mothers
  85. Captopril
    • ACE Inhibitor
    • Mech: inc Ang (1-7)
    • Use: AntiHTN/MI/Lt vent dysfxn/heart failure
    • Side effects:dry cough/angiodema
  86. Enalapril
    • ACE Inhibitor
    • Mech: inc Ang (1-7)
    • Use: AntiHTN/MI/Lt vent dysfxn/heart failure
    • Side effects:dry cough/angiodema
  87. Lisinopril
    • ACE Inhibitor
    • Mech: inc Ang (1-7)
    • Use: AntiHTN/MI/Lt vent dysfxn/heart failure
    • Side effects:dry cough/angiodema
  88. Conivaptan
    • Vasopressin Receptor Antagonist
    • Mech: V1/V2 receptor antagonist/IV use to inc Na conc
    • Use: hyponatremia caused by SIADH/
  89. Tolvaptan
    • Vasopressin Receptor Antagonist
    • Mech: V2 receptor antagonist/oral
    • Use: hypervolemic and euvolemic hyponatremia associated with HF/cirrhosis/SIADH
  90. Aliskiren
    • Renin Inhibitor
    • Use: essential HTN
    • Side effects: GI/allergic symptoms

What would you like to do?

Home > Flashcards > Print Preview