What happens when MAOi's are added?
What is cheese effect?
- - causes release of stored MAs
- - can lead to hypertensive crisis
- - normally degraded by MAO
- - accumulation of tyramine --> crosses BBB --> activates sympathetic NS
- - MAOi also inhibits NA degradation
- - therefore get exacerbated increase in sympathetic system
- cheese effect --> cheese has lots of tyramine