ANTI-INFLAMMATORY DRUGS

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Author:
lazzsant
ID:
109300
Filename:
ANTI-INFLAMMATORY DRUGS
Updated:
2011-10-24 17:33:50
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ANTI INFLAMMATORY
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ANTI_INFLAMMATORY
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  1. Nonsteroidal Anti-Inflammatory Drugs (6)
    • 1) Salicylates
    • 2) Propionic Acid Derivatives
    • 3) Acetic Acid Derivatives
    • 4) Indole Derivatives
    • 5) Oxicams
    • 6) Coxibs
  2. Salicylates
    • 1) Aspirin
    • 2) Sulfasalazine
  3. Propionic Acid Derivatives
    • 1) Flurbiprofen
    • 2) Ibuprofen
    • 3) Naproxen
    • 4) Oxaprozin
  4. Acetic Acid Derivatives
    • 1) Diclofenac
    • 2) Ketorolac
    • 3) Sulindac
  5. Indole Derivatives
    Indomethacin
  6. Oxicams
    • 1) Meloxicam
    • 2) Piroxicam
  7. Coxibs
    Celecoxib
  8. Analgesic- Antipyretic Drugs
    Acetaminophen
  9. Short- to - medium acting Glucocorticoids
    • 1) Cortisone
    • 2) Hydrocortisone
    • 3) Methylprednisolone
    • 4) Prednisolone
    • 5) Prednisone
  10. Intermediate- Acting Glucocorticoids
    Triamcinolone
  11. Long-acting Glucocorticoids
    • 1) Betamethasone
    • 2) Dexamethasone
  12. NSAIDS MOA
    • COX 1 & COX 2 reversible inhibition
    • Anti-inflammatory
    • Analgesic
    • Antipyretic
  13. Aspirin (Clinical & contra)
    • NSAID - Salicylate
    • irreversible COX inhibitor

    • Clinical: (80-325 = anti-platelet) (300-600 = analgesic) (1000 = anti-inflammatory)
    • thromboembolic

    • CONTRA: pregnancy
    • GI problems
    • nephropathy
    • Reyes Syndrome
  14. Sulfasalazine
    • NSAID- Salicylate
    • COX and LOX inhibitor

    Clinical: Crohns & ulcerative colitis
  15. Ibuprofen
    • NSAID- Propionic Acid Derivative
    • Clinical:
    • close ductus arteriosas
    • children with viral fever
  16. Ketorolac
    NSAID- Acetic Acid Derviative

    • Clinical:
    • powerful analgesic (dec opioid requirement)
    • inflammatory condition with the eye

    A/E: Increased renal toxicity
  17. Indomethacin
    • NSAID - Indole Derivative
    • MOA:
    • inhibits phospholipase A& C
    • dec neutrophil migration, and B & T cell proliferation
  18. Meloxicam
    • NSAID - Oxicam
    • MOA: COX 2 inhibitor
    • Clinical: osteoarthritis
  19. Celecoxib
    • NSAID - Coxib
    • Fewer GI problems
    • BLACK BOX b/c cardiac problems
    • Contra:
    • warfarin (potentiation)
    • pregnancy (inhibits labor)
  20. Acetaminophen
    • Analgesic-Antipyretic
    • Not anti-inflammatory
    • MOA: COX 1 & COX 2 Centrally only
    • A/E: NAPQ1 (glutathione)
    • Treat with Charcoal or NAC
    • Alcohol induces CYP450 -> more NAPQ1
  21. Dexamethasone
    • Long- acting Glucocorticoid
    • Clinical: diagnosis of Cushings
    • Treatment of Renal dysfunction
  22. Piroxicam
    • Oxicam
    • MOA:
    • Nonselective COX inhibitor
    • inhibits PMN leukocyte migration (high doses)
    • dec Oxygen radical species (high)
    • Inhibits lymphocyte fx (high)

    A/E: inc incidence of peptic ulcer and bleeding (high doses)

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