Hypothalamus - Pituitary Drugs

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Author:
catitasilva
ID:
109323
Filename:
Hypothalamus - Pituitary Drugs
Updated:
2011-10-16 13:12:15
Tags:
hypothalamus pituitary drugs
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Description:
hypothalamus pituitary drugs
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  1. Mecasermin
    Tx?
    A/E?
    MOA?
    • Mecasermin (rIGF-1; TARGET TISSUE)
    • Tx: Laron syndrome (mutated GH-R or Ab to GH-R)
    • A/E:Hypoglycemia (administor W/snack)
    • MOA:give W/RIGF BP-3 clasts longer)
    • -short statue due IGF-I deficiency w/high GH;IGF-1
  2. Sermorelin
    MOA?
    TX?
    • MOA:GHRF
    • TX:Diagnostic,GH def, weight loss in AIDS,lack of GHRH/F
  3. Octreotide
    TX?
    A/E?
    ADMIN?
    • TX:GH overactivity-acromegaly
    • -supress ectopic hormone production by tumors
    • -45x more potent than somatostatin
    • Admin SC(3x/day),IM(1x/mo)
    • A/E: GI side effects;Vit B12 def.conevery tissue responsive somatostatin

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