pharm-HTN

Card Set Information

Author:
ekdldksk
ID:
109451
Filename:
pharm-HTN
Updated:
2011-10-16 20:22:42
Tags:
hypertension
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Description:
hypertension drugs
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  1. drug classes for hypertension
    - Diuretics

    - Sympathoplegics

    - Vasodilators

    - Angiotensin antagonists
  2. Diuretics (hypertension)
    - Chlorothiazide

    - Furosemide

    - Spironolactone

    - Mannitol
  3. Chlorothiazide
    • - diuretic drug for hypertension
    • - @ DCT - inhibits Na/Cl symporter --> retains Na - H2O --> excretion
    • - toxicity: hypokalemia
  4. Furosemide
    - Diuretic drug for HTN

    - @ loop of henle (ascending limb)

    - Na/K/Cl symporter, Ca excretion -> retains ions -> H2O -> excretion

    - Toxicity : hypokalemia
  5. Spironolactone
    - Diuretic drug for HTN

    - @ CT – aldosterone antagonist

    - Retains Na&H2O à excretion

    - Toxicity: HYPERkalemia
  6. Mannitol
    - Diuretic drug for HTN

    • - @ loop of Henle (descending limb) –
    • osmotic agent

    - inhibits H2O reabsorption -> excretion

    - Toxicity: hyponatremia, hyperkalemia
  7. Sympathoplegics
    - Clonidine(a2 agonist)

    - Reserpine

    - Nicotinic R blocker

    - Prazosin (a1 blocker)

    - Propanolol (b1 blocker)
  8. Clonidine
    -sympathoplegic drug for HTN

    -a-2 agonist
  9. Reserpine
    - sympathoplegic drug for HTN

    - inhibits MA packaging and release
  10. Propanolol
    - sympathoplegic drug for HTN

    - b-blocker --> heart --> inhibits contraction
  11. Prazosin
    - sympathoplegic drug for HTN

    - a1 blocker --> arterioles
  12. Vasodilators (HTN) - 3 classes
    - nitrovasodilators (hydralazine)

    - k-channel agonists (hyperpolarizes cell --> inhibits contraction)

    - L-type Ca Channel blockers (verapamil, diltiazem, nifedipine)
  13. Hydralazine
    - vasodilator (HTN)

    - inhibits GC --> relaxes vasc SM --> dec peripheral R
  14. Angiotensin antagonists (2)
    - ACEi - captopril ("-pril")

    - ARB - losartan ("-tan")

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