pharm-MI

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Author:
ekdldksk
ID:
109461
Filename:
pharm-MI
Updated:
2011-10-16 21:02:35
Tags:
MI cholesterol heart failure
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Description:
MI drugs, cholesterol, heart failure, cardiac arrhythmias
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  1. MI Symptomatic Drugs (3 classes)
    - nitroglycerin

    - Ca-channel blockers (verapamil, diltiazem, nifedipine)

    - beta blocker (propanolol)
  2. Nitroglycerin
    - MI drug - dec venous return via vasc SM relaxation

    - treats: silent & variant angina

    - toxicity: heart attack, hypotension
  3. Ca-channel blockers (MI drug)
    - verapamil, diltiazem, nifedipine

    - peripheral vasodilation

    - treats: silent & variant angina

    - toxicity: hypotension, edema
  4. What does propanolol treat as a myocardial ischemia symptomatic drug?
    - treats silent angina
  5. 4 Classes of drugs that decreases cholesterol levels
    - statins

    - resins

    - niacin

    - fibrates
  6. Lovastatin
    - statin drug to decrease chol.

    - inhibits HMG-CoA reductase --> inhibits chol. synthesis
  7. Cholestyramine
    - resin drug to decrease chol.

    - inhibits chol. reabsorption into gut --> excreted
  8. Niacin
    - drug to dec chol.

    - dec VLDL release from liver
  9. Gemfibrozil
    - fibrate drug to dec chol.

    - inc syn. of lipoprotein lipase --> breaks down VLDL --> chol removed from blood & deposited in tissue
  10. Prophylactic drugs for MI (3 classes and examples of each)
    - anticoagulant - warfarin

    - fibrinolytic drugs

    - anti-platelet - ibuprofen, dipyridamole, clopidogrel
  11. Warfarin
    - anticoagulant (MI) - prevents venous clotting

    - inhibits vitamin k epoxide
  12. Ibuprofen/aspirin
    - anti-platelet drug (MI)

    - inhibits COX & TxA2 formation --> inhibit fibrin clot formation

    - toxicity: bleeding, GI ulcer
  13. Dipyridamole
    - anti-platelet drug (MI)

    - competitive inhibitor for thromboxane synthetase --> inhibits TxA2 synthesis
  14. Clopidogrel
    - anti-platelet drug (MI)

    - inhibits adenosine R --> inhibits platelet response

    - toxicity: bleeding, rash
  15. Heart Failure Drugs (5 classes and examples)
    • 1. positive ionotropic drugs (cardiac glycosides)
    • - digoxin

    • 2. Diuretics
    • - chlorothiazide, furosemide, spironolactone

    • 3. Angiotensin antagonists
    • - captopril, losartan

    • 4. PDE inhibitors
    • - theophylline, vardenafil

    • 5. Vasodilators
    • - nitroglycerin
  16. Digoxin
    - positive ionotropic drug/cardiac glycoside

    - inhibits Na/K ATPase --> inc contractility

    - activates PS effect --> dec HR

    • - toxicity: arrhythmias, blur
  17. Cholrothiazide, furosemid, spironolactone
    - diuretics for Heart failure

    - dec bv

    - toxicity: hypokalemia
  18. Captopril, Losartan
    - angiotensin antagonists for heart failure

    - ACEi --> dec ang II

    - ARB --> comp. antagonist for AT1-R

    -toxicity: renal damage
  19. Theophylline, vardenafil
    - PDE inhibitors (heart failure)

    - inc cGMP --> vasodilation
  20. Cardiac Arrhythmia Drugs (4 Classes & examples)
    - Class I = Na channel blockers (lidocaine)

    - Class II = B-blocker (propanolol)

    - Class III = K channel blockers (amiodarone)

    - Class IV = Ca channel blocker (verapamil, diltiazem)
  21. Lidocaine
    - class I drug for CA

    - Na channel blocker
  22. Propanolol (CA)
    - class II CA drug

    - slows AV conduction + dec HR& contractility
  23. Amiodarone
    - class III CA drug

    - K channel blocker

    - prolongs PR interval --> prolongs ventricular AP

    ** delays repolarization
  24. Verapamil, Diltiazem
    - Class IV CA drug

    - Ca channel blocker

    - slows AV conduction

    - prolongs PR interval

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