Psyc drugs

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  1. What type of drugs are haloperidol/chlorpromazine?
    Typical/first generation antipsychotics
  2. Use of haloperidol/chlorpromazine?
    Common & serious side effects?
    What advice would you give the patient?
    • 1. schizophrenia, psychosis, delirium
    • 2. sedation, tardive dyskinesia, anticholinergic effects.
    • NMS, cardiac (long QT)
    • 3. Baseline ECG reqd. Avoid alcohol, careful when driving
  3. What are antimuscarinic effects?
    Dry mouth, constipation, blurred vision, dizziness
  4. Name 3 atypical antipsychotics?
    Quetiapine, Olanzapine, Clozapine
  5. Common & serious SEs of atypical antipsychotics?
    • Common: sedation, weight gain, [antimusc]
    • dry mouth, constipation, blurred vision
    • Serious: DM/DKA, NMS causing high fever, heart, kidney probs
    • Clozapine --> clozapenia (neutropinia)
  6. What is respiridone?
    Atypical antipsychotic, "watered down haloperidol" (maintains some dyskinesia)
  7. Name 3 benzodiazepines?
    Diazepam, lorazepam, clozapam
  8. What are benzos used for?
    short term for anxiety, insomnia also seizures, alcohol withdrawal
  9. Common & serious SEs of benzos?
    • Common: sedation/drowsy, can muddle
    • thinking, mess with memory
    • Serious: cause dependence, decrease breathing
  10. Name 3 SSRIs
    Fluoxetine, Paroxetine, Citalopram
  11. Common & serious side effects of SSRIs?
    • Common – FINISH (fat, insomnia, nausea,
    • irrit/anxiety, sex func dec, headaches)
    • Serious – initial inc in suicidal thoughs
  12. What advice would you give pt starting SSRIs?
    • 4-6 wks for people to notice effect
    • Initial increase in anxiety/suicide thoughts so need follow up after 1-2 wks.
    • Withdrawal slowly
    • Will need to be on it for 6 months after feeling better (2-3y if recurrent)
  13. What are amitryptiline & nortryptiline & how does it work?
    • Tricyclics
    • seratonin & NA reuptake inhibition
    • Has effects on histamine receptor, a receptor and anticholinergic
  14. Common & serious SEs of TCAs?
    • Common – [antichol] dry mouth, blurred vision, constipation, sedation [antihist], hT, dizzy [a recep], weight gain
    • Serious – seizures, coma, arrythmias
  15. Order of prescribing antidepressants?
    • 1. SSRIs
    • 2. (try diff SSRI)
    • 3. TCA
    • 4. SNRI
    • 5. MAOI
  16. What is venlafaxine?
    SNRI (seratonin, noradrealine reuptake inhib)
  17. What might a patient switch to SNRIs from TCAs?
    Less sedative & antimuscarinic effects
  18. Common & serious SEs of venlafaxine?
    • Common: rash, [HTN] which if sustained has effects on your body, headaches, tummy upset
    • Serious: Heart effects if stopped suddenly
  19. Example of a MAOI & major SE?
    • Selegiline
    • Hypertensive crisis - special diet required
  20. What is lithium & what is it used for?
    • Mood stabiliser
    • Mania, bipolar
  21. Common & serious SEs of Lithium?
    • Common = 4T’s: tremor, terrible kidney (pee lots),
    • tummy upset, thyroid inc
    • Serious – teratogenic, kidney and heart arrythmias, seizures, coma if too much
  22. What is lamotragine?
    Antiepileptic/mood stabiliser
  23. Lamotragine SEs?
    Common/serious - cerebellar sx, blood dx (bleeding, infection)
  24. What are sodium valproate/Carbamazepine? When are they used in psychiartry?
    • Antiepileptics/mood stabilisers
    • Used as mood stabilisers when unresponsive/can't use Li
  25. Common & serious SEs of sodium valproate/carbamazepine?
    • Common: Sedation, headache, cerebellar
    • Serious: Blood dx (bleeding, infec)
    • (NaVal) – teratogen
    • (Carba) – Increase suicidal thoughts
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Psyc drugs
Psyc drugs final year exam
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