Path acute/chronic inflam

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Author:
jlolson83
ID:
109779
Filename:
Path acute/chronic inflam
Updated:
2011-10-17 22:23:05
Tags:
Pathology Acute Chronic Inflammation
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  1. Acute Inflammation Major Features
    • Vascular changes leading to inc bl flow
    • Inc vascular perm
    • Emigration, accum, act leukocytes/Mphage
  2. Acute Inflammation Cellular events
    • Leukocyte adhesion/transmigration
    • Chemotaxis (chemoattractants)
    • Leukocyte activation
    • Phagocytosis
  3. Inflammatory chemical mediators
    • Vasoactive amines (Histamine, Serotonin)
    • Plasma Proteins (complement, kinins, clotting F)
    • Arachidonic acid metabolites
    • Platelet act F
    • Cytokines/chemokines
    • NO
    • Free radicals
    • Neuropeptides
    • Other (hypoxia-induced factor 1a, uric acid)
  4. Histamine and Serotonin
    • Preformed (h: mast cells, basophils, pl) (s: pl,enterochromaffin cells)
    • Response to: phys inj, immune rxn, anaphylatoxins, neuropeptides (substance P), IL-1, IL-8
    • Vasodilation
  5. Bradykinin
    • Inc vascular permeability
    • sm m contraction
    • vasodilation
    • pain
  6. Clotting system
    • Thrombin (mobilize P-selectin, chemokines, endothelial adhesion molecules, induces COX-2, PAF, NO)
    • Plasmin (activates complement, fibrin-split products, Hageman factor)
  7. NO
    • Produced by endothelium, macrophages, some neurons
    • sm m relaxation
    • microbicidal
  8. Lysosomal contents
    • Primary (myeloperoxidase, lysozyme, acid hydrolases, neutral proteases)
    • Secondary (lysozyme, collagenase, lactoferrin, plasminogen activator, histaminase, alk phos)
  9. Antioxidants
    • Ceruloplasmin
    • Transferrin
    • Superoxide dismutase
    • Catalase
    • Glutathione
    • Vitamin A/E
  10. Acute Inflammation: Morphologic patterns
    • Serous
    • Fibrinous (inflamm of linings of cavities)(may resolve or organize)
    • Suppurative (abscess of purulent material)
    • Ulcers
  11. Chronic Inflammation
    • Eg: TB, syphilis, leprosy
    • Mononuclear (not neutrophil) infiltrate
    • Ongoing attempted tissue replacement
    • Macrocytes all over. Also lymphocytes, plama cells, eosinophils, mast cells
    • Granulomatous inflam
  12. Granulomatous inflammation processes
    • TB
    • Sarcoidosis
    • Cat-scratch
    • lymphogranuloma inguinale
    • leprosy
    • brucellosis
    • syphilis
    • berylliosis (dust in lung)
  13. Granulomatous inflammation histologically
    • Epithelioid histiocytes
    • Giant cells (langhans - peripheral nuclei) (foreign body giant cells - haphazard nuclei)
  14. Molecular/cellular effects of fever
    • Pyrogens (endotoxin, IL-1, TNF)
    • Acute-phase reactants (CRP, fibrinogen, serum amyloid A)
    • Left shift leukocytes

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