Quiz 4 - Phar 605

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VASUpharm14
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109997
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Quiz 4 - Phar 605
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2011-10-18 22:08:29
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  1. Voltaren
    generic?
    diclofenac sodium (oral)
  2. Voltaren
    class?
    nonsteroidal anti-inflammatory
  3. Voltaren
    MOA?
    unknown. Possibly decreased prostaglandins, thromboxanes, and prostacyclin formation through inhibition of cyclooxygenase (COX).
  4. Voltaren
    dosage form?
    Tablets (enteric)
  5. Voltaren XR
    generic?
    diclofenac sodium (oral)
  6. Voltaren XR
    class?
    nonsteroidal anti-inflammatory
  7. Voltaren XR
    MOA?
    unknown. Possibly decreased prostaglandins, thromboxanes, and prostacyclin formation through inhibition of cyclooxygenase (COX).
  8. Voltaren XR
    dosage form?
    Tablets (EXTENDED)
  9. Cardizem
    generic?
    diltiazem hydrochloride
  10. Cardizem
    class?
    antihypertensive/antianginal
  11. Cardizem
    MOA?
    calcium channel blocker - inhibits the movement (influx) of calcium ions across specific cellular membranes (slow channels) which: 1) dilates coronary arteries and arterioles, 2) inhibits coronary spasm, 3) lowers arterial blood pressure, 4) slows SA and AV conduction, and 5) prolongs AV node ERT and FRP. Produces its antihypertensive effects by decreasing peripheral resistance.
  12. Cardizem
    dosage form?
    • Tablets (regular, LONG ACTING -LA)
    • Capsules (SR, CD, XT)
    • Injection
  13. Cartia
    generic?
    diltiazem hydrochloride
  14. Cartia
    class?
    antihypertensive/antianginal
  15. Cartia
    MOA?
    calcium channel blocker - inhibits the movement (influx) of calcium ions across specific cellular membranes (slow channels) which: 1) dilates coronary arteries and arterioles, 2) inhibits coronary spasm, 3) lowers arterial blood pressure, 4) slows SA and AV conduction, and 5) prolongs AV node ERT and FRP. Produces its antihypertensive effects by decreasing peripheral resistance.
  16. Cartia
    dosage form?
    • Tablets (regular, LONG ACTING -LA)
    • Capsules (SR, CD, XT)
    • Injection
  17. Tiazac
    generic?
    diltiazem hydrochloride
  18. Tiazac
    class?
    antihypertensive/antianginal
  19. Tiazac
    MOA?
    calcium channel blocker - inhibits the movement (influx) of calcium ions across specific cellular membranes (slow channels) which: 1) dilates coronary arteries and arterioles, 2) inhibits coronary spasm, 3) lowers arterial blood pressure, 4) slows SA and AV conduction, and 5) prolongs AV node ERT and FRP. Produces its antihypertensive effects by decreasing peripheral resistance.
  20. Tiazac
    dosage form?
    • Tablets (regular, LONG ACTING -LA)
    • Capsules (SR, CD, XT)
    • Injection
  21. Lamictal
    generic?
    lamotrigine
  22. Lamictal
    class?
    antiepileptic
  23. Lamictal
    MOA?
    unknown. Possibly inhibition of voltage-sensitive sodium channels, resulting in a stabilization of neuronal membranes and modulation of presynaptic transmitter release of excitatory amino acids.
  24. Lamictal
    dosage form?
    Tablets (chewable, oral, orally-disintegrating)
  25. Lamictal XR
    generic?
    lamotrigine
  26. Lamictal XR
    class?
    antiepileptic
  27. Lamictal XR
    MOA?
    unknown. Possibly inhibition of voltage-sensitive sodium channels, resulting in a stabilization of neuronal membranes and modulation of presynaptic transmitter release of excitatory amino acids.
  28. Lamictal XR
    dosage form?
    Tablets (EXTENDED)
  29. Effexor
    generic?
    venlafaxine hydrochloride
  30. Effexor
    class?
    antidepressant
  31. Effexor
    MOA?
    associated with its potentiation of neurotransmitter activity in the CNS. Active metabolite are potent inhibitors of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine reuptake.
  32. Effexor
    dosage form?
    Tablets
  33. Effexor XR
    generic?
    venlafaxine hydrochloride
  34. Effexor XR
    class?
    antidepressant
  35. Effexor XR
    MOA?
    associated with its potentiation of neurotransmitter activity in the CNS. Active metabolite are potent inhibitors of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine reuptake.
  36. Effexor XR
    dosage form?
    • Tables (EXTENDED)
    • Capsules (EXTENDED)
  37. Aspirin, enteric-coated
    generic?
    Aspirin, enteric-coated
  38. Aspirin, enteric-coated
    class?
    hematological agent
  39. Aspirin, enteric-coated
    MOA?
    inhibits prostaglandin and thromboxane A2 synthesis by acetylating the enzyme cyclooxygenase. Prostaglandins sensitize pain receptors resulting in a lower pain threshold. By inhibiting their production, aspirin raises the pain threshold so fewer pain impulses reach the CNS. Thromboxane A2 induces platelet aggregation and causes vasoconstriction. Aspirin permanently inhibits the thromboxane A2 in platelets for the life of the platelet.
  40. Aspirin, enteric-coated
    dosage form?
    Tablets (enteric regular, MAXimum strength enteric)
  41. Celebrex
    generic?
    celecoxib
  42. Celebrex
    class?
    nonsteroidal anti-inflammatory
  43. Celebrex
    MOA?
    produces anti-inflammatory, analgesic, and antipyretic effects by inhibiting prostaglandin synthesis through inhibition of cyclooxygenase-2 (COX-2). At therapeutic levels, celecoxib has little or no effect on cyclooxygenase-1 (COX-1)
  44. Celebrex
    dosage form?
    Capsules
  45. Valium
    generic?
    diazepam
  46. Valium
    class?
    antianxiety agent
  47. Valium
    MOA?
    benzodiazepines facilitate the inhibitory neurotransmitter action of gamma-aminobutyric acid (GABA), which mediates both pre- and post-synaptic inhibition in all regions of the CNS.
  48. Valium
    dosage form?
    • Tablets
    • Injection
    • Oral concentrate (Intensol)
    • Rectal Gel (Diastat)
  49. Lunesta
    generic?
    eszopiclone
  50. Lunesta
    class?
    sedative
  51. Lunesta
    MOA?
    a pyrrolopyrazine derivative of the cyclopyrrolone class. Structually unrelated to benzodiazepines. MOA unknown, thought to act at GABA-receptor complexes at binding sites located near or coupled to benzodiazepine receptors.
  52. Lunesta
    dosage form?
    Tablets (film-coated)
  53. Flomax
    generic?
    tamsulosin hydrochloride
  54. Flomax
    class?
    prostate anti-inflammatory
  55. Flomax
    MOA?
    benign prostatic hyperplasia (BPH) commonly found in men over age of 50 years. BPH is caused by slow increase in the size of prostate gland, a small gland that sits below the bladder and surrounds the bladder outlet, and by an increase in the smooth muscle tone in the prostate and bladder neck. Tamsulosin is a selective apha-adreneric blocking agent for receptors found on the prostate which will relax the prostate gland and blader neck to increase urinary flow and reduce symptoms of BPH.
  56. Flomax
    dosage form?
    Capsules
  57. Aricept
    generic?
    donepezil hydrochloride
  58. Aricept
    class?
    agent for Alzheimer's Dementia
  59. Aricept
    MOA?
    AD is characterized by early changes in cholinergic pathways in the CNS, incuding a deficiency of cortical acetycholine. Donepezil hydrochloride is a reversible acetylcholinesterase inhibitor that works centrally to increase the amount of acetylcholine available at cholinergic synapses.
  60. Aricept
    dosage form?
    Tablets (regular, orally-disintegrating - Aricept ODT)
  61. Reglan
    generic?
    metoclopramide hydrochloride
  62. Reglan
    class?
    antiemetic
  63. Reglan
    MOA?
    inhibition of dopamine receptors which results in decreased nerve transmission from afferent nerves to the vomiting center and an increase in the vomiting center threshold.
  64. Reglan
    dosage form?
    • Tablets
    • Syrup
    • Injectible
  65. Zyloprim
    generic?
    allopurinol
  66. Zyloprim
    class?
    agent for gout
  67. Zyloprim
    MOA?
    competitively inhibits xanthine oxidase which is the enzyme responsible for the conversion of hypoxanthine to xanthine to uric acid. Metabolized to alloxanthine which also inhibits xanthine oxidase.
  68. Zyloprim
    dosage form?
    • Tablets
    • Solution for injection
  69. Prozac
    generic?
    fluoxetine hydrochloride
  70. Prozac
    class?
    antidepressant
  71. Prozac
    MOA?
    blocks the neuronal uptake of serotonin, but not of norepinephrine, into human platelets in the CNS. Binds much less potently than classical tricyclic antidepressant to muscarinic, histaminergic, and alpha-adrenergic receptors.
  72. Prozac
    dosage form?
    • Tablets
    • Capsules (regular, delayed-released - Prozac Weekly)
    • Liquid
  73. Lantus
    generic?
    insulin glargine, rDNA origin
  74. Lantus
    class?
    antidiabetic
  75. Lantus
    MOA?
    recombinant human insulin analog that is long-acting. Primary hormone responsible for carrying proper glucose utilization in metabolic processes and insulin in adipose and muscle tissue will activate specific enzymes, promotes the transport of monosaccharides (including glucose) across cell membranes and facilitates the transformation of intracellular amino acids into proteins.
  76. Lantus
    dosage form?
    Injection
  77. Actos
    generic?
    pioglitazone hydrochloride
  78. Actos
    class?
    antidiabetic
  79. Actos
    MOA?
    a thiazolidinedione antidiabetic agent that decreases insulin resistance by improving target cell response to insulin. Thought to act by binding to peroxisome proliferator-activated receptor-gamma (PPAR) that regulate the transcription of a number of insulin responsive genes critical for the control of glucose and lipid metabolism. Requires insulin for activity. Increases insulin-dependent glucose disposal, reduces hepatic gluconeogenesism, and enhances cellular responsiveness to insulin and thus, improves dysfunctional glucose homeostasis.
  80. Actos
    dosage form?
    Tablets
  81. Dyazide
    generic?
    triamterene with hydrochlorothiazide
  82. Dyazide
    class?
    diuretic
  83. Dyazide
    MOA?
    inhibits the reabsorption of sodium in exchange for potassium at the distal renal tubule.
  84. Dyazide
    dosage form?
    Capsules
  85. Maxzide
    generic?
    triamterene with hydrochlorothiazide
  86. Maxzide
    class?
    diuretic
  87. Maxzide
    MOA?
    inhibits the reabsorption of sodium in exchange for potassium at the distal renal tubule.
  88. Maxzide
    dosage form?
    Tablets (Maxzide, Maxzide-25)
  89. Miralax
    generic?
    polyethylene glycol 3350, NF
  90. Miralax
    class?
    laxative
  91. Miralax
    MOA?
    osmotic agent which causes water to be retained with the stool.
  92. Miralax
    dosage form?
    Powder for solution
  93. Glycolax
    generic?
    polyethylene glycol 3350, NF
  94. Glycolax
    class?
    laxative
  95. Glycolax
    MOA?
    osmotic agent which causes water to be retained with the stool.
  96. Glycolax
    dosage form?
    Powder for solution
  97. Omnicef
    generic?
    cefdinir
  98. Omnicef
    class?
    cephalosporin antibiotic
  99. Omnicef
    MOA?
    third generation cephalosporin which inhibits bacterial cell wall synthesis via acylation of the transpeptidase enzyme.
  100. Omnicef
    dosage form?
    • Capsules
    • Powder for oral suspension
  101. Levaquin
    generic?
    levofloxacin
  102. Levaquin
    class?
    fluoroquinolone antibiotic
  103. Levaquin
    MOA?
    fluoroquinolone which exerts its antibacterial actions by preventing the synthesis of bacterial DNA through inhibition of the enzyme DNA gyrase.
  104. Levaquin
    dosage form?
    • Tablets
    • Oral solution
    • Injection (concentrate, premix)
  105. Niaspan
    generic?
    niacin (ER)
  106. Niaspan
    class?
    antihyperlipidemic
  107. Niaspan
    MOA?
    aka nicotinic acid, functions in teh body after conversion to nicotinamide adenine dinucleotide (NAD). Niacin (not nicotinamide) lowers cholesterol by a mechanism unrelated to its actions as a vitamin. It increases lipoprotein lipase activity, decreases lipolysis in adipose tissue, and decreases esterification of triglycerides in the liver. The net result is a decrease in synthesis of VLDL which lowers LDL and triglycerides and raises HDL.
  108. Niaspan
    dosage form?
    Tablets (EXTENDED)

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