Path T3 tricks.txt

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Author:
kepling
ID:
110177
Filename:
Path T3 tricks.txt
Updated:
2011-10-19 16:12:12
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Path T3 tricks
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Path T3 tricks
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  1. What activates NK-cells for tumor killing?
    IL-2
  2. How do Tumor cells bind to new ECM?
    • Laminin
    • Integrins w/ reverse polarity
  3. What makes up a teratoma?
    • Ectoderm
    • Mesoderm
    • Endoderm
    • *** hair, teeth, skin and other cells all present in same tumor
  4. What cell transducer can activate RAS by becoming inactivated?
    NF-1 b/c it normally forms a GTPase to hydrolyze GTP-GDP
  5. Diff b/t grading and staging tumors?
    • Grading: differentiation of cells
    • Staging: metasteses of cells
  6. Which test is best for malignancy? Why?
    Southern blot b/c it picks up the best monoclonality of B/T cells
  7. Fastest decreasing cncer in developing countries?
    Gastric adenocarcinoma
  8. What is the first general metasteses site?
    Lymph nodes
  9. T/F pulmonary sarcomas are not related to smoking?
    True
  10. What is the Rate limiting step in tumor cell differentiation?
    Telomerase shortening
  11. What type of cancer is most common in immunodeficiecy cases?
    Lymphoma
  12. What is a leiomyoma and what is its origin?
    • Smooth muscle cell tumor
    • origin: mesenchymal cells
  13. Main cytokine responsible for cachexia?
    TNF-alpha
  14. Name the 2 neuroectodermal neoplasma?
    • Nevus
    • Malignant Melanoma
  15. name the seven neoplasms that are always malignant?
    • Hepatoma
    • Melanoma
    • Multiple myeloma
    • Mesothelioma
    • Lymphoma
    • Glioma
    • Seminoma
  16. name the 5 cardiac neoplasms?
    • Myxoma
    • Rhabdomyoma
    • Papillary fibroelastoma
    • Lipoma
    • Angiosarcoma
  17. Name the 5 common pediatric neoplasms
    • Hamangioma
    • Port-wine-stain
    • Lymphangioma
    • Hygroma
    • Teratoma
  18. Largest tumor compatible with life?
    1kg (10 doublings of 1g tumor)
  19. Why is a Hemangioma a special case of a benign neoplasm?
    It is the only un-encapsulated benign neoplasm
  20. Two neoplasms that do not metastasize?
    • Glioma
    • BCC
  21. What neoplasms participate in Hematologic spread?
    Sarcomas

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