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What activates NK-cells for tumor killing?
How do Tumor cells bind to new ECM?
- Integrins w/ reverse polarity
What makes up a teratoma?
- *** hair, teeth, skin and other cells all present in same tumor
What cell transducer can activate RAS by becoming inactivated?
NF-1 b/c it normally forms a GTPase to hydrolyze GTP-GDP
Diff b/t grading and staging tumors?
- Grading: differentiation of cells
- Staging: metasteses of cells
Which test is best for malignancy? Why?
Southern blot b/c it picks up the best monoclonality of B/T cells
Fastest decreasing cncer in developing countries?
What is the first general metasteses site?
T/F pulmonary sarcomas are not related to smoking?
What is the Rate limiting step in tumor cell differentiation?
What type of cancer is most common in immunodeficiecy cases?
What is a leiomyoma and what is its origin?
- Smooth muscle cell tumor
- origin: mesenchymal cells
Main cytokine responsible for cachexia?
Name the 2 neuroectodermal neoplasma?
name the seven neoplasms that are always malignant?
- Multiple myeloma
name the 5 cardiac neoplasms?
- Papillary fibroelastoma
Name the 5 common pediatric neoplasms
Largest tumor compatible with life?
1kg (10 doublings of 1g tumor)
Why is a Hemangioma a special case of a benign neoplasm?
It is the only un-encapsulated benign neoplasm
Two neoplasms that do not metastasize?
What neoplasms participate in Hematologic spread?