p chem t4

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p chem t4
2011-10-19 11:45:16

physiological chemistry t4
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  1. What is unique to the mucosal cells?
    The ability to reutilize the glycerol in the monoglyceride acylation pathway.
  2. What is the major pathway of triglyceride resynthesis?
    Monoglyceride acylation pathway
  3. When is the scavenger pathway of mucosal cells mostly used?
    in between meals
  4. Only antigenic lipid known
  5. Glycerophospholipids
    • Phosphatidylcholine (lecithin)
    • Phosphatidylserine
    • Phosphatidylethanolamine (cephalin)
    • Phosphatidylinositol
    • Plamalogens
    • Cardiolipin
  6. Phospholipid functions (to name a few)
    • building blocks of membranes.
    • components of lipoproteins. contribute constituents (DAG and IP3) to intracellular signal transduction pathways, and to eicosanoid biosynthesis. Play a role in blood coagulation (plasmalogen-PAF). Functional elements of bile (lecithin) and lung surfactant (DPPC).
  7. Cephalin methylates with what to what?
    with 3SAM to hepatic lecithin (phosphatidylcholine)
  8. Important SAM methylations
    Each methyl group of choline and carnitine. The methyl in epinephrine. Methyls in catecholamine degradation products (catalyzed by COMT). The methyl for modifying purine and pyrimidine bases in DNA and RNA. Methyl for the 5' cap of eukaryotic messenger RNA.
  9. Structure of cardiolipin
    Glycerol holding two phosphatidic acid residues together.
  10. Where is cardiolipin found?
    Bacterial membranes and inner mitochondrial membranes.
  11. Pulmonary surfactant
    • Made up of DPPC (dipalmitoylphosphatidylcholine).
    • Decreases the surface tension of alveolar membranes, thus helping to keep alveoli open for gas exchange.