Pathology Oncogenes

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Author:
jlolson83
ID:
110569
Filename:
Pathology Oncogenes
Updated:
2011-10-20 13:35:04
Tags:
Path oncogenes
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  1. SIS (PBGFP)
    PDGFB chain GF

    Overexpression

    Astrocytoma, osteosarcoma
  2. HST1
    FGF

    Overexpression

    Stomach CA
  3. INT2 (FGF3)
    FGF

    Amplication

    Bladder, Breast, Melanoma
  4. TGFA
    TGF-a

    Overexpression

    • Astrocytoma
    • Hepatocelllular carcinoma
  5. HGF
    HGF

    Overexpression

    Thyroid CA
  6. ERBB1 (EGFR), ERBB2
    EGFRs

    Overexpression

    Squamous cell carcinoma of lung, glioma
  7. FLT3
    FMS-like Tyr Kinase 3

    Amplification

    Breast, ovarian CA
  8. RET
    R for neurotrophic F

    Point mutation

    Leukemia, endocrine neoplasia 2A/B, familial medullary thyroid carcinomas
  9. PDGFRB
    PDGF R

    Overexpression, translocation

    Gliomas, leukemias
  10. KIT
    R for stem cell F

    Point mutation

    GI stromal tumors, seminomas, leukemia
  11. KRAS
    GTP binding

    Point mutation

    Colon, lung, pancreatic tumors
  12. HRAS
    GTP binding

    Point mutation

    Bladder and kidney tumors
  13. NRAS
    GTP-binding

    Point mutation

    Melanoma, hematologic malignancies
  14. ABL
    Nonreceptor tyr kin

    Translocation

    Chronic yeloid leukemia, acute lymphoblastic leukemia
  15. BRAF
    RAS signal transduction

    Point mutation

    Melanoma
  16. B-catenin
    WNT signal transduction

    Point mutation, overexpression

    Hepatoblastoma, hepatocellular carcinoma
  17. C-MYC
    Transcriptional activators

    Translocation

    Burkitt lymphoma
  18. N-MYC
    Transcriptional activators

    Amplification

    Neuroblastoma, small-cell carcinoma of lung
  19. L-MYC
    Transcriptional activators

    Amplification

    Small-cell carcinoma of lung
  20. Cyclin D
    Cyclins

    Translocation; amplification

    Mantle cell lymphoma; breast and esophageal
  21. Cyclin E
    Cyclin

    Overexpression

    Breast
  22. CDK4
    Cyclin dep kinase

    Amplification or point mutation

    Glioblastoma, melanoma, sarcoma
  23. RET
    MEN type IIA,IIB

    Familial medullary thyroid carcinoma, Hirschprung disease
  24. EGFR
    overexpression

    Lung tumors, glioblastomas, head and neck tumors

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