Pathology Viral Carcinogenesis

Card Set Information

Author:
jlolson83
ID:
110673
Filename:
Pathology Viral Carcinogenesis
Updated:
2011-10-20 18:06:34
Tags:
Pathology Viral carcinogenesis
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  1. HPV
    • integrated into host cell genome in cancer
    • early viral gene products: E6 binds p53, E7 binds RB
    • Squamous cell carcinoma of cervix/anogenital, oral and laryngeal cancer
  2. Epstein-Barr
    • Enters B cells via CD21
    • latent membrane protein-1 (LMP-1) mimicks CD40
    • Burkitt's lymphoma, B-cell lymphoma, Hodgkins's lymphoma, nasopharyngeal carcinomas
  3. Hep V
    • Liver CA
    • Probably dev through insertional mutagenesis
  4. Human T-Cell Leukemia Virus Type 1
    • topism for CD4+ T Cells
    • Long latent period
  5. H. Pylori
    • bacterium, not virus
    • gastric carcinomas, lymphomas

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