Cancer Genes S3M2

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Author:
lancesadams
ID:
110935
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Cancer Genes S3M2
Updated:
2011-10-21 20:21:57
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Ross S3M2
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Pathology
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  1. Chronic myelogenous leukemia (CML) involves what gene
    BCR-ABL
  2. What is the CML translocation site
    t(9;22)
  3. What is the result of a BCR-ABL mutation
    • Philadelphia chromosome causing excess tyrosine kinase
    • Chronic myelogenous leukemia (CML)
  4. What drug is used to treat CML
    Imatinib mesylate (Gleevec)
  5. Acute pro-myelocytic leukemia is caused by mutation in what genes
    PML and RARA (Retinoic acid receptor)
  6. What translocation takes place with Acute pro-myelocytic leukemia (APML)
    t(15;17)
  7. What is the result of RAR-PML gene fusion
    Results in maturation arrest of granulocytes at the pro-myelocytic stage
  8. Burkitts lymphonma invloves what Genes
    c-MYC
  9. Burkitts lymphoma is a result of what translocation
    t(8;14)
  10. Over expression of the proto oncogene of MYC is a result of what condition
    Burkitt lymohoma
  11. Follicular Lymphoma has what gene involvement
    BCL2 producing products that prevent mitochondrial leakage of cytochrome c
  12. What translocation has taken place with Follicular Lymphoma
    t(14;18)
  13. What is the end result of Follicular lymphoma
    Over expression of BCL2 resulting in immortality of B-Lymphocytes
  14. Ewing Sarcomas involve what genes
    FLI1 and EWSR1
  15. What translocation takes place in a Ewing Sarcoma
    t(11;22)
  16. What is seen in an x-ray, and biopsy of a Ewing sarcoma
    A mass on the bone with an onion skin pattern with a biopsy revealing a malignant tumor with a round dark blue nuclei
  17. What genes are involved in a Mantle cell lymphoma
    FLI1 and EWSR1
  18. What are the the manifestations of a Mantle cell lymphoma
    Generalized non-tender lymphadenopathy in a elderly male patient
  19. What is the resulting effect of a Mantle cell lymphoma gene modification
    Amplification of proto-oncogene cyclin D1 promoting the movement of cells from the G phase to the S phase
  20. Breast cancer has what gene involvement
    ERBB2 or HER-2 gene amplification
  21. What drugs are used for Breast cancer treatment
    Trastumuzab (Herceptin)
  22. What genes are involved in a Neuroblastoma
    Amplification of N-MYC
  23. What is the function of APC gene, and what cancer is it associated with
    • Prevents nuclear transcription
    • Familial polyposis coli
  24. What is the function of the TGF-beta gene, and what cancer is it associated with
    • Inhibits G1 to S phase
    • Pancreatic and Colorectal cancer
  25. What is the function of the BRCA1 and 2 genes, and what cancer they associated with
    • Regulates DNA repair
    • Breast cancer and ovarian cancer
  26. What is the function of the RB gene, and what cancers is it associated with
    • Inhibits G1 to S phase
    • Retinoblastoma and Osteogenic sarcoma
  27. What is the function of the PTCH gene, and what cancer is it associated with
    • Encodes cell membrane protein
    • Gorlin syndrome (Nevoid basal cell), sporadic basal cell carcinoma
  28. What is the role of E2F in cell cycling
    It activates genes essential for progression through the S phase
  29. What must be mutated for a child to acquire retinoblastoma
    Both alleles of the Rb locus must be inactivated
  30. What is the role of NF-1, and what cancer is it related with
    • Regulates signal transduction by inactivating RAS proteins
    • Neurofibromatosis type I
  31. What are the symptoms of Neurofibromatosis type I
    Numerous neurofibromas, optic nerve glioma, cafe au lait spots, iris hamartoma
  32. NF-2 has what role and is found in what cancer
    • Binds to actin and CD44
    • Neurofibromatosis type II (bilateral schwannoma of acoustic nerve)
  33. What is the role of the p53 gene
    Inhibits transition from the G1 to S phase
  34. What are some of the cancers related to the p53 gene
    • Li-Fraumeni s yndrome
    • HPV
    • Breast cancer
    • brain tumors
    • leukemia
  35. What is the role of the VHL gene, and what cancer is it associated with
    • Regulates nuclear transcription
    • Von Hippel Lindau syndrome
    • Renal cell carcinoma
  36. What is the role of the PTEN gene, and what cancer is it associated with
    • Regulates nuclear transcription
    • Endometrial carcinoma
  37. What is the role of the WT1 gene, and what cancer is it associated with
    • Regulates gene transcription
    • Wilms tumor
  38. What is the function of the INK4a/ARF genes, and what cancer are they related to
    • Encodes tumor suppressor genes p53 and Rb
    • Melanoma, Pancreatic adenocarcinoma
  39. What is the role of BCL-2 and what cancer is it associated with
    • Produce gene products that prevent mitochondrial leakage of cytochrome c
    • B Cell Lymphoma
  40. Xeroderma pigmentosa is an example of what defect
    Nucleotide excision repair defect
  41. What are examples of cancer caused by a defect in Recombination repair
    • Bloom syndrome
    • ataxia-telangiectasia
    • Fanconi anemia
    • BRCA
  42. MSH2 and MLH1 have what role and are found defected in what cancer
    • DNA mismatch repair of genes
    • Colon carcinoma

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