Quiz 5 Phar 605

Card Set Information

Author:
VASUpharm14
ID:
110991
Filename:
Quiz 5 Phar 605
Updated:
2011-10-25 01:00:26
Tags:
im too cool
Folders:

Description:
Top 81-100
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user VASUpharm14 on FreezingBlue Flashcards. What would you like to do?


  1. Zestoretic
    generic?
    lisinopril with hydrochlorothiazide
  2. Zestoretic
    class?
    antihypertensive
  3. Zestoretic
    MOA?
    a number of different actions, most related to suppression of the renin-angiotensin-aldosterone system. Competitively inhibits angiotensin-converting enzyme (ACE) to decrease synthesis of angiotensin II, one of the most potent vasoconstrictors known. Then this leads to decrease release of aldosterone, that then decreases sodium and water reabsorption and lowers plasma volume. Also involved with degradation of bradykinin, a vasodilator. Hydrochlorothiazide inhibits the reabsorption of sodium and chloride at the distal renal tubule.
  4. Zestoretic
    dosage form?
    Tablets
  5. Prinzide
    generic?
    lisinopril with hydrochlorothiazide
  6. Prinzide
    class?
    antihypertensive
  7. Prinzide
    MOA?
    a number of different actions, most related to suppression of the renin-angiotensin-aldosterone system. Competitively inhibits angiotensin-converting enzyme (ACE) to decrease synthesis of angiotensin II, one of the most potent vasoconstrictors known. Then this leads to decrease release of aldosterone, that then decreases sodium and water reabsorption and lowers plasma volume. Also involved with degradation of bradykinin, a vasodilator. Hydrochlorothiazide inhibits the reabsorption of sodium and chloride at the distal renal tubule.
  8. Prinzide
    dosage form?
    Tablets
  9. Tricor
    generic?
    Fenofibrate (nanocrystallized)
  10. Tricor
    class?
    antihyperlipidemic
  11. Tricor
    MOA?
    lowers Total-C, LDL-C, and triglycerides by activation of peroxisome proliferator activated receptor-a (PPARa). Through this mechanism, fenofibrate increases lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of apoprotein C-III. A decrease in triglycerides results in a change in the composition of LDL to larger particles which are catabolized rapidly. Also reducing serum uric acid levels in hyperuricemic and normal individuals by increasing urinary excretion of uric acid.
  12. Tricor
    dosage form?
    Tablets (nanocrystallized)
  13. Geodon
    generic?
    ziprasidone hydrochloride
  14. Geodon
    class?
    antipsychotic
  15. Geodon
    MOA?
    exact mechanism unknown. Thought to act by antagonism of dopamine D2 and serotonin 5HT2 receptors. Also shown to be an antagonist at histamine H2 and alpha-1-adrenergic receptors.
  16. Geodon
    dosage form?
    • Capsules
    • Injection
    • Suspension
  17. Benicar
    generic?
    olmesartan medoxomil
  18. Benicar
    class?
    antihypertensive
  19. Benicar
    MOA?
    Angiotensin II is a potent vasoconstrictor, the primary vasoactive hormone of the renin-angiotensin system and an important component in the pathophysiology of hypertension. It also stimulates aldosterone secretion by the adrenal cortex. Olmesartan medoxomil is a prodrug which is hydrolyzed to olmesartan during absoprtion from the GI tract. Olmesartan blocks the vasoconstrictor and aldosterone-secreting effects of antiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor found in many tissues. Olmesartan does not inhibit ACE, nor does it bind to or block other hormone receptors or ion channels known to the be important in cardiovascular regulation.
  20. Benicar
    dosage form?
    Tablets
  21. Armour Thyroid
    generic?
    thyroid, dessicated
  22. Armour Thyroid
    class?
    hormone/thyroid
  23. Armour Thyroid
    MOA?
    exact mechanism unknown. Thought to be due to protein synthesis control, resulting in: (1) a regulation of growth and development, (2) an increase in metabolic rate, (3) inhibition of the secretion of thyrotropin by the pituitary, and 94) various effects on lipid and carbohydrate metabolism.
  24. Armour Thyroid
    dosage form?
    Tablets
  25. Abilify
    generic?
    aripiprazole
  26. Abilify
    class?
    antipsychotic
  27. Abilify
    MOA?
    exact mechanism unknown. May be due to a combination of partial agonist activity at dopamine D2 and serotonin 5-HT1A receptors and antagonist activity at 5-HT2A receptors. Metabolized by CYP3A4 and CYP2D6 enzymes to dehydro-aripipazole following oral administration and has some activity at the D2 receptors and represents 40% of the parent drug exposure in plasma.
  28. Abilify
    dosage form?
    • Tablets (regular, ODT)
    • Oral solution
    • Injection
  29. Zantac
    generic?
    ranitidine hydrochloride
  30. Zantac
    class?
    gastric antisecretory
  31. Zantac
    MOA?
    competitively and reversibly inhibits histamine at the H2 receptors, including receptors on gastric cells. H2 antagonists are highly selective, they do not affect H1 receptors and do not affect acetylcholine. Ranitidine inhibits fasting and nocturnal secretions, secretions stimulated by food, caffeine, and insulin, and secretions casued by histimine, gastrin, and muscarinic agonists.
  32. Zantac
    dosage form?
    • Tablets (regular, EFFERdose)
    • Syrup (peppermint flavor)
    • Injection
  33. Roxicodone
    generic?
    oxycodone hydrochloride
  34. Roxicodone
    class?
    opioid analgesic
  35. Roxicodone
    MOA?
    analgesia produced centrally via action on the central opiate receptors. Other therapeutic effects of oxycodone include anxiolysis, euphoria, and feelings of relaxation. Respiratory depression occurs via direct action on brain stem respiratory centers. Depression of the cough reflex occurs via direct action on the cough center in the medulla. Oxycodone causes a reduction in motility associated with an increase in smooth muscle tone in the antrum of the stomach and duodenum.
  36. Roxicodone
    dosage form?
    • Tablets
    • Solution
    • Concentrate
  37. Altace
    generic?
    ramipril
  38. Altace
    class?
    antihypertensive
  39. Altace
    MOA?
    thought to be due to its suppression of the renin-angiotensin-aldosterone system by competitively inhibiting the angiotensin-converting enzyme (ACE). ACE converts angiotensin I to angiotensin II, one of the most potent vasoconstrictors known. Inhibition of ACE decreases plasma angiotensin II which leads to decreased aldosterone secretion. The latter may cause an increase in serum potassium. The net result is a decrease in peripheral arterial resistance.
  40. Altace
    dosage form?
    Capsules
  41. Plavix
    generic?
    clopidogrel bisulfate
  42. Plavix
    class?
    hematological agent
  43. Plavix
    MOA?
    inhibits platelet aggregation by irreversibly modifying platelet receptors thereby selectively inhibiting the binding of adenosine diphosphate (ADP) to the receptor. This results in an inhibition of the ADP-mediated activation of the glycoprotein GPIIb/IIIa complex and an inhibition of platelet aggregation.
  44. Plavix
    dosage form?
    Tablets
  45. Zetia
    generic?
    ezetimibe
  46. Zetia
    class?
    antihyperlipidemic
  47. Zetia
    MOA?
    a class of lipid-lowering compounds that selectively inhibits the intestinal absorption of cholesterol and related phytosterols. It appears to act at the brush border of the small intestine to inhibit cholesterol absorption thereby decreasing the delivery of cholesterol to the liver. After oral administration, ezetimibe is absorbed and extensively conjugated to a pharmacologically active phenolic glucuronide.
  48. Zetia
    dosage form?
    Tablets
  49. Aldactone
    generic?
    spironolactone
  50. Aldactone
    class?
    diuretic
  51. Aldactone
    MOA?
    competitive antagonism of aldosterone, primarily at the aldosterone-dependent Na+/K+ exchange sites in the distal convoluted renal tubule.
  52. Aldactone
    dosage form?
    Tablets
  53. Spiriva
    generic?
    tiotropium bromide (inhalation)
  54. Spiriva
    class?
    antiasthmatic
  55. Spiriva
    MOA?
    a long-acting antagonist of the action of acetylcholine at the M3-receptors in the smooth muscle of the bronchial tree. This antagonism results in bronchodilation which lasts for greater than 24 hours. Chemically, tiotropium is a synthetic, non-chiral, quaternary ammonium compound.
  56. Spiriva
    dosage form?
    Inhalation powder
  57. Pepcid
    generic?
    famotidine
  58. Pepcid
    class?
    gastric antisecretory
  59. Pepcid
    MOA?
    competitively inhibits histamine at the H2 receptors, including receptors on gastric cells. This inhibition is reversible. Both the acid concentration and volume of gastric secretion are suppressed. Changes in pepsin secretion are proportional to volume output. Inhibits basal, nocturnal, and food stimulated gastric secretion.
  60. Pepcid
    dosage form?
    • Tablets
    • Powder for oral suspension (cherry-banana-mint flavor)
    • Premixed injection
    • Injection
  61. Mytussin AC
    generic?
    codeine phosphate with guaifenesin
  62. Mytussin AC
    class?
    antitussive/expectorant
  63. Mytussin AC
    MOA?
    Guaifenesin promotes lower respiratory tract drainage by thinning bronchial secretions, lubricating irritated respiratory tract membranes through increased mucous flow, and facilitating removal of viscous, inspissated mucous. Codeine depresses the cough reflex center in the medulla oblongota.
  64. Mytussin AC
    dosage form?
    Syrup
  65. Robitussin AC
    generic?
    codeine phosphate with guaifenesin
  66. Robitussin AC
    class?
    antitussive/expectorant
  67. Robitussin AC
    MOA?
    Guaifenesin promotes lower respiratory tract drainage by thinning bronchial secretions, lubricating irritated respiratory tract membranes through increased mucous flow, and facilitating removal of viscous, inspissated mucous. Codeine depresses the cough reflex center in the medulla oblongota.
  68. Robitussin AC
    dosage form?
    syrup
  69. Tri-Cyclen
    generic?
    norgestimate and/with ethinyl estradiol
  70. Tri-Cyclen
    class?
    oral contraceptive
  71. Tri-Cyclen
    MOA?
    suppression of luteinizing hormone (LH) and follicle stimulation hormone (FSH) result in the inhibition of ovulation. Thickening of the cervical mucous (inhibiting sperm penetration) and alteration of the endometrium (which inhibits implantation) may also contribute to their effectiveness.
  72. Tri-Cyclen
    dosage form?
    • Tablets
    • 28 day Dialpaks (7 green inert tablets)
  73. TriSprintec
    generic?
    norgestimate and/with ethinyl estradiol
  74. TriSprintec
    class?
    oral contraceptive
  75. TriSprintec
    MOA?
    suppression of luteinizing hormone (LH) and follicle stimulation hormone (FSH) result in the inhibition of ovulation. Thickening of the cervical mucous (inhibiting sperm penetration) and alteration of the endometrium (which inhibits implantation) may also contribute to their effectiveness.
  76. TriSprintec
    dosage form?
    • Tablets
    • 28 day Dialpaks (7 green inert tablets)
  77. Trinessa
    generic?
    norgestimate and/with ethinyl estradiol
  78. Trinessa
    class?
    oral contraceptive
  79. Trinessa
    MOA?
    suppression of luteinizing hormone (LH) and follicle stimulation hormone (FSH) result in the inhibition of ovulation. Thickening of the cervical mucous (inhibiting sperm penetration) and alteration of the endometrium (which inhibits implantation) may also contribute to their effectiveness.
  80. Trinessa
    dosage form?
    • Tablets
    • 28 day Dialpaks (7 green inert tablets)
  81. Motrin
    generic?
    ibuprofen
  82. Motrin
    class?
    nonsteroidal anti-inflammatory
  83. Motrin
    MOA?
    produces a reversible inhibition of cyclooxygenase which results in a decreased synthesis of prostaglandins. Prostaglandins sensitize pain receptors resulting in a lower pain threshold. By inhibiting their production, ibuprofen raises the pain threshold so fewer pain impulses reach the CNS. Prostaglandins are involved in setting the normal set point in the thermoregulatory center of the hypothalamus. By inhibiting their production, ibuprofen resets the normal set point and increases heat loss from the body through increased cutaneous blood flow and sweating. Prostaglandins are also involved in vasodilation and plasma exudate formation at inflammation sites. Again inhibiting their production, ibuprofen can decrease inflammation.
  84. Motrin
    dosage form?
    • Tablets
    • nonprescription - liquid, chewable (for children)
  85. Namenda
    generic?
    memantine hydrochloride
  86. Namenda
    class?
    agent for Alzheimer's Dementia
  87. Namenda
    MOA?
    Persistant activation of central nervous system N-methyl-D-aspartate (NMDA) receptors by the excitatory amino acid glutamate has been hypothesized to contribute to the symptomatology of Alzheimer's disease. Memantine is thought to exert its therapeutic effect through its action as a low to moderate affinity uncompetitive (open-channel) NMDA receptor antagonist. It binds perferentially to the NMDA receptor-operated cation channels. It shows little to no affinity for GABA, benzodiazepine, dopamine, adrenergic, histamine, and glycine receptors or for voltage-dependent Ca2+, Na+, or K+ channels. It does show antagonistic effects at the 5HT3 receptor and a slight inhibition of nicotinic acetylcholine receptors.
  88. Namenda
    dosage form?
    • Tablets
    • Oral solution (alcohol-free, sugar-free)
  89. Namenda XR
    generic?
    memantine hydrochloride
  90. Namenda XR
    class?
    agent for Alzheimer's Dementia
  91. Namenda XR
    MOA?
    Persistant activation of central nervous system N-methyl-D-aspartate (NMDA) receptors by the excitatory amino acid glutamate has been hypothesized to contribute to the symptomatology of Alzheimer's disease. Memantine is thought to exert its therapeutic effect through its action as a low to moderate affinity uncompetitive (open-channel) NMDA receptor antagonist. It binds perferentially to the NMDA receptor-operated cation channels. It shows little to no affinity for GABA, benzodiazepine, dopamine, adrenergic, histamine, and glycine receptors or for voltage-dependent Ca2+, Na+, or K+ channels. It does show antagonistic effects at the 5HT3 receptor and a slight inhibition of nicotinic acetylcholine receptors.
  92. Namenda XR
    dosage form?
    Capsules (EXTENDED)
  93. Folic Acid
    generic?
    folic acid
  94. Folic Acid
    class?
    vitamin
  95. Folic Acid
    MOA?
    an important vitamin required for the synthesis of thymidylate, synthesis of purine nucleotides, and for maintenance of normal erythropoiesis. A deficiency of folic acid can result from inadequate dietary intake, from diseases of the small intestine, and from diseases of the liver which interfere with the recirculation of folate through enterohepatic cycle. Folic acid deficiency can lead to megaloblastic anemias in adults and children and in neural tube defects in unborn infants.
  96. Folic Acid
    dosage form?
    • Tablets (OTC, Rx)
    • Injection
  97. Folacin
    generic?
    folic acid
  98. Folacin
    class?
    vitamin
  99. Folacin
    MOA?
    an important vitamin required for the synthesis of thymidylate, synthesis of purine nucleotides, and for maintenance of normal erythropoiesis. A deficiency of folic acid can result from inadequate dietary intake, from diseases of the small intestine, and from diseases of the liver which interfere with the recirculation of folate through enterohepatic cycle. Folic acid deficiency can lead to megaloblastic anemias in adults and children and in neural tube defects in unborn infants.
  100. Folacin
    dosage form?
    • Tablets (OTC, Rx)
    • Injection
  101. Pteroylglutamine Acid
    generic?
    folic acid
  102. Pteroylglutamine Acid
    class?
    vitamin
  103. Pteroylglutamine Acid
    MOA?
    an important vitamin required for the synthesis of thymidylate, synthesis of purine nucleotides, and for maintenance of normal erythropoiesis. A deficiency of folic acid can result from inadequate dietary intake, from diseases of the small intestine, and from diseases of the liver which interfere with the recirculation of folate through enterohepatic cycle. Folic acid deficiency can lead to megaloblastic anemias in adults and children and in neural tube defects in unborn infants.
  104. Pteroylglutamine Acid
    dosage form?
    • Tablets (OTC, Rx)
    • Injection
  105. Folate
    generic?
    folic acid
  106. Folate
    class?
    vitamin
  107. Folate
    MOA?
    an important vitamin required for the synthesis of thymidylate, synthesis of purine nucleotides, and for maintenance of normal erythropoiesis. A deficiency of folic acid can result from inadequate dietary intake, from diseases of the small intestine, and from diseases of the liver which interfere with the recirculation of folate through enterohepatic cycle. Folic acid deficiency can lead to megaloblastic anemias in adults and children and in neural tube defects in unborn infants.
  108. Folate
    dosage form?
    • Tablets (OTC, Rx)
    • Injection
  109. Keflex
    generic?
    cephalexin monohydrate
  110. Keflex
    class?
    cephalosporin antibiotic
  111. Keflex
    MOA?
    first generation cephalosporin which inhibits bacterial cell wall synthesis via acylationof the transpeptidase enzyme. This acylation occurs in the third and final stage of bacterial cell wall synthesis and is believed to be due to the structural similarity of the cephalosporin nucleus to D-alanyl-D-alanine.
  112. Keflex
    dosage form?
    • Tablets
    • Capsules
    • Powder for oral suspension

What would you like to do?

Home > Flashcards > Print Preview