Griseoflulvin causes what side effect? and if used long term causes this side effect?
Is a teratogen and therefore contraindicated in pregnancy. If used long term will cause bone marrow suppression
Which drus are ototoxic?
aminoglycosides like genamicin and amikacin
Which anibiotic is CI in renal and hepatic failure? Which version of this drug is ok in animals with these problems?
tetracyclines. Doxy ok
What is a long acting GCC used in IBD and diabetes mellitus?
Ergotism toxicity causes what clincial signs?
vasoconstriction with terminal necrosis of the extremities d.t thrombosis affected animals predisposed to frostbite and gangrene. may have CNS efects, potenet oxytocic action or pituitary effects --> decreased prolactin leading to agalactia
What is the hypoadrenocortisism-like syndrome blood chemistry like?
reproductive dysfunction like estrogenism, vulvovaginitis
Fumonisin is associated with moldy corn and leads to what toxic clinical signs?
equine leukoencephalomalacia ;
hypertension and pulmonary edema in pigs PPE
Tichotecenes are what?
cytotoxic mycotoxins that lead to immunosuppression and vomiting
lameness and hyperthermia
Glycopyrolate will cause what clinical signs when given correctly?
Dantrolene causes what signs?
muscle relaxant for post anesthesia myositis in horses and for dags/cats with functional urethral obstruction
Pilocarpine is what type of drug?
miotic sometimes used to treat glaucoma
Which drug, if given, will incrase toxicosis d/t warfarin? how?
Sulfa. by displacing the anticoagulant from plasma binding sites and leading to increased free toxin.
Name the drugs used most frequenctly for improving diastolic fxn and preventing thromboembolism in cats wiht HCM
beta blockers (atenolol);
Ca2+ blockers (diltiazem)
diuretics if in heart failure
aspriin or clopidogrel
What type of drug is amlodipine? uses?
Ca2+ blocker to prevent hypertension in chronic renal failure.
Which anesthetic gas has a breakdown toxin that can be nephrotoxic?
sevoflurane to compound A
how does Calcium gluconate treat hyperhalaemia?
antagonizes the effects of elevated serum K on myocardium. keeps myocardial tissue normally excitable so the heart rhythm doesn't develop a life threatening bradycardia
What is 2-pralidoxime used for?
reversal agent for cholinesterase inhibitors
what is a reversal agent for benzodiazepines?
In horses, what is the most nephrotoxic aminoglycocide drug in order?
amphotercin b, neomycin, streptomycin, entamicin, amikacin?
neomycin (most) then gentamicin, amikacin, streptomycin. amphotercin b is an anti-fungal
What does monesin do and what is its toxicity?
coccidiostat for increased productivity in cattle. Horses toxicity presents as myocardial necrosis and development of dilated cardiomyopathy. pregressive respiratory distress, heart murmur, weakness, and hypovolemic shock.
Name the disease associated with each toxic plant:
fiddleneck = amsinckia
yellow star thistle