Muscle relaxants

Card Set Information

Author:
lazzsant
ID:
111228
Filename:
Muscle relaxants
Updated:
2011-10-29 21:19:18
Tags:
Ross Pharm
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Description:
Muscle relaxants
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  1. Tubocurarine
    -Onset
    -Duration
    -Metabolism
    -extra effects
    • Long onset 3-5
    • Long Duration 30-60
    • Most not metabolized (60% renal)
    • Blocks Nn, Dec BP, inc HR, inc [Histamine] alot
    • Dont use in asthmatics, allerges, or hypotensive patients
  2. Vecuronium
    -Onset
    -Duration
    -Metabolism
    -extra effects
    • Long 3-5
    • Intermediate 30
    • 85% liver metabolized
    • No effect on Cardio = excellent for HTN
  3. atracurium
    -Onset
    -Duration
    -Metabolism
    -extra effects
    • I onset 2-3
    • I duration 30
    • Plasma esterases
    • laudanosine (seizures) & dec BP
  4. mivacurium
    -Onset
    -Duration
    -Metabolism
    -extra effects
    • I onset 1.5-3
    • S duration 10-15
    • plasma cholinesterase
    • dec BP
  5. Pancuronium
    -Onset
    -Duration
    -Metabolism
    -extra effects
    • I onset 1-3
    • L duration 60-100
    • 75% renal
    • inc BP and inc HR
  6. rocuronium
    -Onset
    -Duration
    -Metabolism
    -extra effects
    • S onset 1-2
    • L duration 30-60
    • liver metab
  7. Suxamethonium
    -Onset
    -Duration
    -Metabolism
    -extra effects
    • Succinylcholine
    • S onset .5-1
    • S duration 5-10
    • plasma cholinesterase
    • inc HR, inc BP, Hyperkalemia, fasiculations, myoglobinuria.
    • Abn. plasma chE (malignant hyperthermia) = prolonged circulation
    • Stimulates Nn
  8. Drugs that potentiate NMJ blockers
    • General anesthetics
    • aminoglycosides
    • tetracyclines
    • Ca++ channel blockers
  9. Drugs that antagonize NMJ blockers
    • phenytoin and carbamazapine
    • chronic steroids
    • theophylline
  10. Diazepam/ Lorazepam
    Uses
    MOA
    A/E
    Contra
    Spasmolytic

    • dec tone in dysfx muscle while maintaining voluntary control. (MS, stiff mans syndrome)
    • GABA a opening leads to hyperpolarization
    • dependence tolerance
    • TCAD & diazepam = extra depressant on CNS
  11. Baclofen
    MOA
    uses
    A/E
    Spasmolytic

    • GABA b receptor leads to no Ca++ into the terminal.
    • ALS, intrathecal for spasticity, MS, trigeminal neuralgia, polyafferent neuropathic pain.
    • sudden w/d = dysreflexia, breakthrough, ataxia, hallucination
  12. Tizanidine

    Uses
    MOA
    Spasmolytic

    Used: MS, ALS, brain & SC disorders ->spasticity

    MOA: alpha 2 agonist
  13. Gabapentin

    Uses
    MOA
    Toxicity
    Spasmolytic

    Used: generaltonic-clonic seizures

    MOA: dec Ca+ channel activation presynaptically

    Toxicity: somnolence ataxia
  14. Dantrolene

    Uses
    MOA
    A/E
    • Used: cerebral palsy, hemi & paraplegic pts, malignant hyperthermia****
    • neuroleptic malignant syndrome (neuroleptics-haloperidol)
    • Serotonin syndrome (MAOI & SSRI)

    MOA: interfere with dysfunctional ryanodine receptors

    A/E muscle weakness

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