Dose Form EXAM2

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  1. The rate of particle settling in a suspension may be DECREASED by
    • reducing the particle size
    • increasing the particle density
    • increasing the medium viscosity
  2. O/W means _______ internal phase and ________ external phase
    oleaginous ; aqueous
  3. ______ are semisolids with a large percentage of solid material for better absorption of skin secretions
  4. ________ are fine dispersions of liquid or solids in a gaseous medium under pressure
  5. The keratin-rich layer of the epidermis composed of nonliving tissue and allows drugs to penetrate by passive diffusion is called_______
    horny layer or stratum corneum
  6. ______ and ________ are absolute requirements for any ophthalmic
    sterility and isotonicity
  7. Give 2 factors that may enhance percutaneous absorption
    rubbing in; temp; hydration of skin; surface area; conc. of drug at site; etc
  8. Give 2 reasons that ophthalmics need a buffer
    comfort of patient; drug stability; theraputic activity mantenace
  9. _______ are aquesous or oleagenous solutions in the form of coarse droplets or finely divided solids applied topically
  10. ________ is a dispersion in which the dispersed phase is a substance that is neither soluble nor miscible with the vehicle
  11. ointments are also known as ______
  12. ______________ prevent caking and resist settling
    Flocculating agents
  13. Inserts containing ________ are widely used for treating glaucoma
  14. The primary advantage of ophthal. ointments over solutions is _________(incr/decr) ocular contact time
  15. ophthalmic solution droppers should ______ be cleaned with soap and water before and after use
  16. _______ means having the same osmotic pressure while _______ means having the same osmotic pressure as the body
    isosmotic ; isotonic
  17. some drugs that are unstable in water are _______ stable when suspended
  18. mineral oil is a _________ oint. base
  19. colloidal dispersions refer to _________
    gels / magmas
  20. PEGs are _______ oint. bases
  21. ________ must be shaken before use
  22. geometric dilution refers to the incorporation of _________
    very small amounts of drug
  23. a hypotonic solution will ______ RBCs
  24. lanolin is an example of what oint base?
  25. water removable oint. base is also what?
    a hydrophilic oint.
  26. when components are melted together it is an example of the ____ method
  27. over use of nasal solutions for congestion may lead to _______
    rebound congestion
  28. hypertonic solutions lead to ______ of RBCs
  29. particles under ______ reach alveolar ducts
    2 micrometers
  30. emulsifying agents ______ and _____ the dispersion of the internal and external phases
    promote and maintain
  31. What are 2 factors influencing the sedimentation rate of particles in a suspension?
    particle diameter; viscosity of medium; density of particle; density of medium; etc
  32. What are some disadvantages of sugar coating tabs?
    larger; need skill in manufacturing; extra calories; more time; etc
  33. Give the 3 main methods of tablet preparation
    • dry granulation
    • wet granulation
    • direct compression
  34. Creaming of an emulsion is a reversible process if ______ is absent
  35. mineral oil and glycerin are the most common ____ agents when reducing particle size
  36. a coarse dispersion can be called a ______
  37. the dry gum method can be used when preparing a ________
  38. Talc is commonly used as a _______ when manufacturing tabs
  39. spatulation is a type of __________ method when preparing an oint
  40. lactose and cellulose are commonly used as ______ when manufacturing tabs
  41. enteric coated tabs can be coated with ______ or _____
    salol or shellac
  42. _______ is a sugar substitute far sweeter than sucrose and is heat stable
  43. _______ are the preferred preservative for emulsion
  44. ___________ has a sharp taste, which makes it more commonly used as a parenteral preservative
    benzyl alcohol
  45. aspartame is a ______ and _____ sugar
    heat-liable and non-caloric
  46. solutions are a solid, liquid, or gas dissolved in a ____ solvent
  47. in solutions, it is easier to predict the miscibility of ______ than ________
    solids ; oils
  48. alcohol can be used in _____ concentrations when making a syrup
  49. any water-soluble drug that is _____ in water may be added to a flavored syrup
  50. if a drug is not palatable as a solution, the ________ may be rendered flavorless as a suspension
    water insoluble salt
  51. always pour the _______ phase into the ________ phase when making an emulsion
    aqueous ; oleagenous
  52. __________ method can be used to make emulsions of volatile and low viscosity oils
    bottle / shaking
  53. (USP alcohol) dehydrated ethanol is _____ - _____% v/v
  54. (USP alcohol) ethyl alcohol is ____ - ____% v/v
  55. (NF alcohol) diluted ethanol is ____% v/v
  56. ______ and _____ solutions are not used for systemic effect
    otic and ophthalmic
  57. _________ are generally stored in the refrigerator for 7-14 days
    reconstituted powders
  58. ______ ointments are manufactured from sterile ingredients or sterilized after preparation
  59. ______ are alcoholic solutions for topical use
  60. _____ are alcoholic, flavored, sweetened oral solutions
  61. the rate at which a pure chemical dissolves depends on what 2 things?
    particle size; agitation; pH; temp; etc
  62. the 2 types of non-glycogenic sweetners are ________ and ________
    natural and artifical
  63. antimicrobial preservatives are primarily determined by ____________
    free-water concentration
  64. what are some disadvantages of one-way pump sprays?
    drawback contamination, incorrect dosing, back flow; etc
  65. Give 6 characteristics of ophthalmic dosage forms
    sterility; isotonicity; buffering; viscosity; bioavailability; particulate free
  66. what types of solutions need to be sterile, particulate-free, and isotonic?
    ophthalmics, parenterals, irrigation, etc
  67. what 4 techniques can be used to hasten the dissolution process?
    heat; decr. particle size; agitation; use of cosolvent
  68. sorbitol, glycerin, mannitol, and propylene glycol are all ________
    glycogenic non-sugars
  69. what are 3 characteristics of non-glycogenic sweeteners?
    • non-caloric
    • sugar substitute
    • doesn't convert to glucose in the body
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Dose Form EXAM2
Dose Form EXAM2
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