pharm-cns

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Author:
ekdldksk
ID:
112052
Filename:
pharm-cns
Updated:
2011-10-25 12:35:27
Tags:
parkinson ADHD epilepsy
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Description:
disorders of cns
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  1. Drugs used in PD
    • L-DOPA+carbidopa = sinemet
    • bromocriptine
    • amantadine
  2. Drug used for ADHD
    Ritalin = methylphenidate
  3. Drugs used for epilepsy
    • carbamazepine (dec Na; partial & gen t-c)
    • phenytoin (dec Na; partial & gen t-c)
    • valproate (dec Na + inc GABA; p+gen t-c+gen absence)
    • ethosuximide (dec Ca; gen absence)
    • phenobaribtal (inc GABA, dec GLUT; p + gen t-c)
    • benzodiazapines (inc GABA; all 3)
  4. Mechanism of Seizures
    • 1. abnormal voltage-operated channels
    • 2. abnormal receptor-operated channels
    • 3. alterations in EC ionic environment
    • 4. recruitment of normal neurons via anatomical circuit

    focal epileptogenesis --> synchronization --> propagation
  5. phenytoin
    • epileptic drug
    • dec cation influx (Na/Ca)
    • teratogen
    • SE: nystagmus, blur, diplopia

    partial & generalized tonic-clonic
  6. carbamazepine
    • epileptic drug
    • Na channel blocker --> dec Na influx
    • SE: sedation, blur, diplopia, ataxia

    partial & generalized tonic-clonic
  7. valproate
    • epileptic drug
    • blocks v-g Na channels & T-type Ca channels --> dec Na
    • inhibit GABA transaminase --> inc GABA
    • SE: sedation, ataxia, tremors

    all 3
  8. ethosuximide
    • epileptic drug (only for absence seizures)
    • blocks T-type Ca channels
    • SE: fatigue, HA, dizzy, mood changes
  9. phenobarbital
    • inc GABA & inhibit GLUT --> inc hyperpolarization
    • complications: OD potential, teratogen

    Partial & generalized tonic-clonic
  10. benzodiazapines
    • all forms of epilepsy
    • diazepam
  11. topiramate
    • 1. blocks v-g-dependent Na channels --> inhibit neuronal signalling
    • 2. inc GABA --> inc inhibitory effect
    • 3. inhibit AMPA/kainate Rs --> inhibit activation

    may cause glaucoma

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