Card Set Information
atrophy of the anterior pituitary due to a hemorrhage during labor
What are the 5 releasing hormones released from the Hypothalamus?
ADH and Oxytocin are produced by what nuclei in the hypothalamus?
3 Drugs used for Prolactinemia?
Excess GH produces what in Adults?
Whats an example of entrapment neuropathy?
In a normal pt, glucose has what effect on GH?i
it decreases the release of GH
Measurement of what indicates high level os GH?
Somatostatin analog used in acromegaly, carcinoid, glucagonoma, gastrinoma?
Somatostatin has an inhibitory role in 2 places, what releases it?
Hypothalamus--inhibits GH, TSH
D cells of Pancreas and GI--Inhibit gastric, pepsinogen, pancreatic enzymes, gall bladder contraction, insulin and glucagon secretion
Tx for acromegaly?
What are teh 4 best tx for pituitary adenoma?
Growth Hormone receptor Antagonist for Gigantism?
3 strategies to attack osteoporosis?
Raloxifene-estrogen agonist at bone, antagonist at endometrium
Somatropin- GH agonist
GH used for dwarfism?
In a case of Hypo. anterior pituitarism, what hormone decreases first?
GnRH--decreased sexual function
3 causes of Hypo-Ant. pituitarism?
Inflammatory (encephalitis, sarcoidosis)
Pituitary apoplexy (hemorrhagic infact due to a pituitary adenoma)
How to diagnose GH deficiency?
How to diagnose ACTH deficiency?M
Metyrapone--inhibit formation of Cortisol-->increases ACTH release
In hypo-pituitarism, what is the 1st hormone to decrease?
Which one should be treated first?
GnRH goes down first
Should treat with cortisol*** always to maintain sugar and blood pressure
Which ADH receptor mediates vasoconstriction?
ADH V1 receptor acts on what kind of G protein?
Tx for Lithium Induced Nephrogenic DI?
What effect does lithium have on ur sodium level?
causes Hyponatremia bc it displaces it
What happens to sodium in Lithium induced DI?
Hypernatremia vs hyponatremia when there is high plasma levels of Lithium
2 Tx's for neurogenic DI?
Tx for Nephrogenic DI?
2 Drugs that cause DI?
Tx for SIADH?
Conivaptan blocks which receptors?
V1 and V2
What are the 4 Functions of PTH?
increase Ca and phosphate resorption
increase Ca reabsorption from DCT
Increase Phosphoate excretion
Increase 1 alpha hydroxylase so increase 1,25 OH2 Vitamin D calcitrol--increases Intestinal Ca absorption
What causes primary Hyperparathyrodism?
Secondary--low ca leads to High PTH
What is the difference in terms of phosphate homeostasis with PTH and 1,25(OH2)D?
PTH increases CA and decreases Phosphate absorption in kidney
Vitamin D--increases CA and Phosphate reabsorption in intestine