Quiz 6 - Phar 605

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VASUpharm14
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112430
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Quiz 6 - Phar 605
Updated:
2011-10-26 23:18:27
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Top 101-120 wow
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  1. Desyrel
    generic?
    trazodone hydrochloride
  2. Desyrel
    class?
    antidepressant
  3. Desyrel
    MOA?
    inhibits serotonin uptake by brain synaptosomes therefore increasing the behavioral effects of the serotonin precursor, 5-hydroxytryptophan. Extensively metabolized in the liver.
  4. Desyrel
    dosage form?
    Tablets (50, 100, 150, 300 mg)
  5. Soma
    generic?
    carisoprodol
  6. Soma
    class?
    muscle relaxant
  7. Soma
    MOA?
    may work centrally in teh spinal cord or the descending reticular formation to produce muscle relaxation. Exact MOA is unknown. A metabolite of carisoprodol, meprobamate, has sedative and central nervous system relaxation properties.
  8. Soma
    dosage form?
    Tablets (250, 350 mg)
  9. Ovral
    generic?
    norgestrel and ethinyl estradiol
  10. Ovral
    class?
    oral contraceptive
  11. Ovral
    MOA?
    Suppression of luteinizing hormone (LH) and follicle stimulation hormone (FSH) result in the inhibition of ovulation. Thickening of the cervical mucous (inhibiting sperm penetration) and alteration of the endometrium (which inhibits implantation) may also contribute to their effectiveness.
  12. Ovral
    dosage form?
    Tablets
  13. Lo/Ovral
    generic?
    norgestrel and ethinyl estradiol
  14. Lo/Ovral
    class?
    oral contraceptive
  15. Lo/Ovral
    MOA?
    suppression of luteinizing hormone (LH) and follicle stimulation hormone (FSH) result in the inhibition of ovulation. Thickening of the cervical mucous (inhibiting sperm penetration) and alteration of the endometrium (which inhibits implantation) may also contribute to their effectiveness.
  16. Lo/Ovral
    dosage form?
    Tablets
  17. Ogestrel
    generic?
    norgestrel and ethinyl estradiol
  18. Ogestrel
    class?
    oral contraceptive
  19. Ogestrel
    MOA?
    suppression of luteinizing hormone (LH) and follicle stimulation hormone (FSH) result in the inhibition of ovulation. Thickening of the cervical mucous (inhibiting sperm penetration) and alteration of the endometrium (which inhibits implantation) may also contribute to their effectiveness.
  20. Ogestrel
    dosage form?
    Tablets
  21. Cryselle
    generic?
    norgestrel and ethinyl estradiol
  22. Cryselle
    class?
    oral contraceptive
  23. Cryselle
    MOA?
    suppression of luteinizing hormone (LH) and follicle stimulation hormone (FSH) result in the inhibition of ovulation. Thickening of the cervical musous (inhibiting sperm penetration) and alteration of the endometrium (which inhibits implantation) may also contribute to their effectiveness.
  24. Cryselle
    dosage form?
    Tablets
  25. Micronase
    generic?
    glyburide
  26. Micronase
    class?
    antidiabetic
  27. Micronase
    MOA?
    stimulates insulin synthesis and release from beta cells in the pancreatic islets. May also improve binding between insulin and insulin receptors, and increase the number of insulin receptors in the periphery.
  28. Micronase
    dosage form?
    Tablets
  29. Diabeta
    generic?
    glyburide
  30. Diabeta
    class?
    antidiabetic
  31. Diabeta
    MOA?
    stimulates insulin synthesis and release from beta cells in the pancreatic islets. May also improve binding between insulin and insulin receptors and increase the number of insulin receptors in the periphery.
  32. Diabeta
    dosage form?
    Tablets
  33. Benicar-HCT
    generic?
    olmesartan medoxomil with hydrochlorothiazide
  34. Benicar-HCT
    class?
    antihypertensive
  35. Benicar-HCT
    MOA?
    angiotensin II is a potent vasoconstrictor, the primary vasoactive hormone of the renin-angiotensin system and an important component in the pathophysiology of hypertension. It also stimulates aldosterone secretion by the adrenal cortex. Olmesartan medoxomil is a prodrug which is hydrolyzed to olmesartan during absorption from the GI tract. Olmesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor found in many tissues. Olmesartan does not inhibit ACE, nor does it bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation. Hydrochlorothiazide (HCTZ) inhibits the reabsorption of sodium and chloride at the distal renal tubule.
  36. Benicar-HCT
    dosage form?
    Tablets
  37. Cozaar
    generic?
    losartan potassium
  38. Cozaar
    class?
    antihypertensive
  39. Cozaar
    MOA?
    Angiotensin II is a potent vasoconstrictor, the primary vasoactive hormone of the renin-angiotensin system and an important component in the pathophysiology of hypertension. It also stimulates aldosterone secretion by the adrenal cortex. Losartan and its principal active metabolite block the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor found in many tissues. The active metabolite is 10 to 40 times more potent by weight than losartan and appears to be a reversible, non-competitive inhibitor of the AT1 receptor.
  40. Cozaar
    dosage form?
    Tablets
  41. Premarin
    generic?
    conjugated estrogens (systemic)
  42. Premarin
    class?
    hormone/estrogen
  43. Premarin
    MOA?
    a mixture of naturally occuring estrogens derived from pregnant mares' urine. It is composed of estrone, equilin, and 17-alpha-dihydroequilin along with other less prevalent estrogens. Estrogens enter cells of responsive tissues (female genital organs, breasts, hypothalamus, pituitary) and are transported into the nucleus. Inside the cell nucleus, estrogens stimulate specific RNA and protein synthesis. Estrogens also decrease the release of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and luteotropic hormone due to an effect on the pituitary or hypothalamus. Estrogens are important in the development and maintenance of the female reproductive system and secondary sex characteristics.
  44. Premarin
    dosage form?
    • Tablets
    • Premarin Intravenous
  45. Diovan
    generic?
    valsartan
  46. Diovan
    class?
    antihypertensive
  47. Diovan
    MOA?
    angiotensin II is a potent vasoconstrictor, the primary vasoactive hormone of the renin-angiotensin system and an important component in teh pathophysiology of hypertension. It aslo stimulates aldosterone secretion by the adrenal cortex. Valsartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor found in many tissues.
  48. Diovan
    dosage form?
    Tablets
  49. Lidoderm
    generic?
    lidocaine
  50. Lidoderm
    class?
    topical analgesic
  51. Lidoderm
    MOA?
    exhibits neuronal membrane-stabilizing properties by combining with fast sodium channels during their inactive state to inhibit repolarization. The amount of lidocaine that penetrates the skin from topical application is sufficient to produce an analgesic effect but less than the amount necessary to produce a complete sensory block.
  52. Lidoderm
    dosage form?
    • Adhesive patch
    • (also available in topical gels, ointments, and creams)
  53. Vasotec
    generic?
    enalapril maleate
  54. Vasotec
    class?
    antihypertensive
  55. Vasotec
    MOA?
    undergoes hydrolysis after absorption to form the active metabolite enalaprilat. Enalaprilat's effectiveness can be attributed to a number of different actions, most related to suppression of the renin-angiotensin-aldosterone system. It competitively inhibits angiotensin-converting enzyme (ACE), which results in a decreased synthesis of angiotensin II, one of the most potent vasoconstrictors known. The reduction in angiotensin II also decreases the release of aldosterone, which in turn decreases sodium and water reabsorption and lowers plasma volume. The result is a reduction of peripheral arterial resistance and an increase in cardiac output. ACE is also involved with the degradation of bradykinin, a vasodilator.
  56. Vasotec
    dosage form?
    • Tablets
    • Injection
  57. Cialis
    generic?
    tadalafil
  58. Cialis
    class?
    agent for erectile dysfunction
  59. Cialis
    MOA?
    the physiology of the rection of the penis involves the release of nitric oxide in the corpus cavernosum following sexual stimulation. Nitric oxide then activates the enzyme guanylate cyclase which increases cGMP resulting in smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Tadalafil inhibits phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. The increased levels of cGMP allows inflow of blood and resulting erection. Tadalafil has no effect in the absence of sexual stimulation.
  60. Cialis
    dosage form?
    Tablets
  61. Glucotrol
    generic?
    glipizide
  62. Glucotrol
    class?
    antidiabetic
  63. Glucotrol
    MOA?
    is a sulfonylurea antidiabetic medication which stimulates insulin synthesis and release from beta cells in the pancreatic islets. May also improve binding between insulin and insulin receptors, and increase the number of insulin receptors in the periphery.
  64. Glucotrol
    dosage form?
    Tablets
  65. Glucotrol XL
    generic?
    glipizide
  66. Glucotrol XL
    class?
    antidiabetic
  67. Glucotrol XL
    MOA?
    is a sulfonylurea antidiabetic medication which stimulates insulin synthesis and release from beta cells in the pancreatic islets. May also improve binding between insulin and insulin receptors, and increase the number of insulin receptors in the periphery.
  68. Glucotrol XL
    dosage form?
    Tablets
  69. Bactroban
    generic?
    mupirocin (topical)
  70. Bactroban
    class?
    topical antiobiotic
  71. Bactroban
    MOA?
    a naturally-occurring antibiotic produced by fermentation of the organism Pseudomonas fluorescens. Its mechanism of action is derived from an inhibition of bacterial protein synthesis by reversibly and specifically binding to bacterial isoleucyl transfer-RNA synthetase. Mupirocin shows no cross resistance with other antibiotics.
  72. Bactroban
    dosage form?
    • Ointment
    • Nasal ointment
    • Cream
  73. Vytorin
    generic?
    ezetimibe with simvastatin
  74. Vytorin
    class?
    antihyperlipidemic
  75. Vytorin
    MOA?
    in a class of lipid-lowering compounds that selectively inhibits the intestinal absorption of cholesterol and related phytosterols. It appears to act at the brush border of the small intestine to inhibit cholesterol absorption thereby decreasing the delivery of cholesterol to the liver. After oral administration, ezetimibe is absorbed and extensively conjugated to a pharmacologically active phenolic glucuronide. After oral ingestion, simvastatin is hydrolyzed to its b-hydroxyacid form, becoming a specific inhibitor of HMG-CoA reductase. this enzyme is responsible for the conversion of HMG-CoA to mevalonate, an early rate limiting step in the synthesis of cholesterol. In therapeutic concentrations, HMG-CoA reductase is not completely blocked, allowing biologically necessary amounts of mevalonate to be produced. Simvastatin is a substrate for CYP3A4. Vytorin reduces LDL levels and increases HDL concentrations. High LDL and low HDL levels have been shown to be risk factors in coronary heart disease.
  76. Vytorin
    dosage form?
    Tablets
  77. Drisdol
    generic?
    vitamin D, ergocalciferol
  78. Drisdol
    class?
    vitamin
  79. Drisdol
    MOA?
    ultraviolet light converts 7-dehydrocholesterol in the skin to cholecalciferol (Vitamin D3). Both cholecalciferol and ergocalciferol (Vitamin D2) are converted in the liver to 25-hydroxyvitamin D forms and then in the kidney to 1,25-dihydroxyvitamin D forms. Vitamin D (D2 or D3) is essential for the proper regulation of calcium in plasma and the activity of parathyroid hormone. Vitamin D is involved in the absorption of calcium and phosphorous from the small intestine thereby providing the necessary levels of calcium and phosphate in the plasma to promote bone mineralization. Ergocalciferol is effective in treating the hypocalcemia and hyperphosphatemia seen in hypoparathyroidism.
  80. Drisdol
    dosage form?
    • Capsules
    • Drops
  81. Slow FE
    generic?
    ferrous sulfate
  82. Slow FE
    class?
    hematological agent
  83. Slow FE
    MOA?
    Iron is essential for normal erythropoiesis. Iron deficiency in humans can lead to low hemoglobin and hypochromic anemia. Normal dietary iron of 14 mg per day leads to absorption of about 1 mg per day, primarily through the duodenum and upper small intestine. Foods high in iron content include liver, heart, wheat germ, egg yolks, oysters, and some dried beans and fruit. Iron deficiency can result from inadequate intake, interference of iron absorption, or form the loss of blood. About 2/3 of the iron in the body is found in hemoglobin and myoglobin while the remaining amount is stored as aggregated ferritin.
  84. Slow FE
    dosage form?
    Tablets (immediate, Extended = Slow FE).
  85. Amaryl
    generic?
    glimepiride
  86. Amaryl
    class?
    antidiabetic
  87. Amaryl
    MOA?
    stimulates insulin release from beta cells in the pancreatic islets. It may also increase the sensitivity of peripheral tissues to the effects of insulin.
  88. Amaryl
    dosage form?
    Tablets
  89. Boniva
    generic?
    ibandronate sodium
  90. Boniva
    class?
    osteoporosis agent
  91. Boniva
    MOA?
    a bisphosphonate that inhibits osteoclast-mediated bone resorption. Osteoclasts are responsible for the normal turnover of bone structure by breaking it down. Ibandronate's MOA is due to its affinity for hydroxyapatite in the bone thereby reducing the adherence of the osteoblasts to bone. After oral absorption, ibandronate is rapidly bound to bone or is excreted unchanged in the urine.
  92. Boniva
    dosage form?
    • Tablets
    • Injection
  93. Yasmin
    generic?
    drospirenone and ethinyl estradiol
  94. Yasmin
    class?
    oral contraceptive
  95. Yasmin
    MOA?
    Oral contraceptives cause suppression of luteinizing hormone (LH) and follicle stimulation hormone (FSH) resulting in the inhibition of ovulation. Thickening of the cervical mucous (inhibiting sperm penetration) and alteration of the endometrium (which inhibits implantation) may also contribute to their effectiveness. The progestin drospirenone is a spironolactone analogue with antimineralocorticoid activity including the retention of potassium.
  96. Yasmin
    dosage form?
    Tablets, 28 day blister packs
  97. Ocella
    generic?
    drospirenone and ethinyl estradiol
  98. Ocella
    class?
    oral contraceptive
  99. Ocella
    MOA?
    Oral contraceptives cause suppression of luteinizing hormone (LH) and follicle stimulation hormone (FSH) resulting in the inhibition of ovulation. Thickening of the cervical mucous (inhibiting sperm penetration) and alteration of the endometrium (which inhibits implantation) may also contribute to their effectiveness. The progestin drospirenone is a spironolactone analogue with antimineralocorticoid activity including the retention of potassium.
  100. Ocella
    dosage form?
    Tablets, 28 day blister packs
  101. Minocin
    generic?
    minocycline hydrochloride
  102. Minocin
    class?
    tetracycline antibiotic
  103. Minocin
    MOA?
    a tetracycline antibiotic which prevents protein synthesis by competitively binding to the 30 S ribosomal subunits of bacteria. Bacteriostatic at normal dosage ranges.
  104. Minocin
    dosage form?
    Capsules, pellet-filled
  105. Dynacin
    generic?
    minocycline hydrochloride
  106. Dynacin
    class?
    tetracycline antibiotic
  107. Dynacin
    MOA?
    a tetracycline antibiotic which prevents protein synthesis by competitively binding to the 30 S ribosomal subunits of bacteria. Bacteriostatic at normal dosage ranges.
  108. Dynacin
    dosage form?
    Tablets
  109. Solodyn ER
    generic?
    minocycline hydrochloride
  110. Solodyn ER
    class?
    tetracycline antibiotic
  111. Solodyn ER
    MOA?
    a tetracycine antibiotic which prevents protein synthesis by competitively binding to the 30 S ribosomal subunits of bacteria. Bacteriostatic at normal dosage ranges.
  112. Solodyn ER
    dosage form?
    Tablets (EXTENDED)

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