Biochem Lab 2
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Are competitive and non-competive inhibitors reversible or irreversible?
Because they are non-covalently bonded
What is outcome of Maple Syrup Urine Disease?
- Neurological problems
- High mortality rate
What does defect in ornathine amino transferase (OAT) lead to?
What is cofactor?
What is its final conversion product?
Leads to gyrate atrophy of the choroid and retina.
Needed to break down to (final stage) proline
What enzymes do many asians lack that creates problems when drinking alcohol?
What is the problem with the enzyme?
- Normal alcohol process: (mitochondrial enzyme)
- Acetaldeyhde->Aldehyde Dehydrogenase->Acetate
- Have a different form of the enzyme which has a higher KmCausing poor processing of alcohol and acetyladehyde in blood
How to improve Asian's processing of alcohol?
Increase cofactor Niacin, Vitamin B3
What is result of genetic defect Glucose-6-Phosphate 1-dehydrogenase (G6PD)
What can help this problem
Decreased RBC production->hemolytic anemia
Niacin can help
What would you like to do?
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