Biochem Lab 2

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  1. Are competitive and non-competive inhibitors reversible or irreversible?


    Because they are non-covalently bonded
  2. What is outcome of Maple Syrup Urine Disease?
    • Neurological problems
    • High mortality rate
  3. What does defect in ornathine amino transferase (OAT) lead to?

    What is cofactor?

    What is its final conversion product?
    Leads to gyrate atrophy of the choroid and retina.

    Cofactor B6

    Needed to break down to (final stage) proline
  4. What enzymes do many asians lack that creates problems when drinking alcohol?

    What is the problem with the enzyme?
    • Normal alcohol process: (mitochondrial enzyme)
    • Acetaldeyhde->Aldehyde Dehydrogenase->Acetate

    • Have a different form of the enzyme which has a higher Km
    • Causing poor processing of alcohol and acetyladehyde in blood
  5. How to improve Asian's processing of alcohol?
    Increase cofactor Niacin, Vitamin B3
  6. What is result of genetic defect Glucose-6-Phosphate 1-dehydrogenase (G6PD)

    What can help this problem

    Decreased RBC production->hemolytic anemia

    Niacin can help
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Biochem Lab 2
Biochem lab 2
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