Hematological Cell Identification
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The Mitochondria is what to the cell?
- -powerhouse of cell for energy production
What is Lysosome?
Hydrolytic enzymes to destroy bacteria
White Blood cells (leukocytes) defend against..
- -foreign substances
What are Platelets(thrombocytes) ?
- -cytoplasmic fragments of megakaryocytes
- -stops bleeding
What is the primary site of cell production?
Bone Marrow provides what?
best source of study for production and maturation of cells
Diagnostic cells may only be present?
Bone marrow is examined by who?
by the Pathologist
What happens during the second week of Fetal Development?
In what month does granulocytes and megakaryocytes happen during the fetal development?
The second month
What happens in the fourth and fifth month of fetal development?
4th month lymphocytes , 5th month monocytes
What does a immature nucleus looks like?
- -large, almost occupying the entire cell
- -N/C ratio is high
- -usually round to oval
Describe an immature nucleus
- chromatin fine and delicate
- stains reddish purple
- usually with 1 or more nucleoli
Name the cell
The nucleus in a band cell is what shape?
- rod or band
- *indentation greater than half the width of round nucleus
- chromatin coarser and clumped
What is the ratio of nucleus to cytoplasm on a band?
What is the most frequently occuring cells in peripheral blood?
In the regulation of Neutrophil cells what is released first?
segmented cells released first before the bands
What percentage of bands released in circulation?
only a small percentage
What is Diapedesis?
Neutrophils move into tissues thru narrow junctions between endothelial cells of blood vessels
What is the size of an Eosinophil?
Describe the nucleus on a Eosinophil?
- usually two lobes
- coarse & clumped chromatin
Describe the cytoplasm on an Eosinophil?
- Bright reddish-orange specific granules
- granules distinct & uniform size
What happens in IgE hypersensitivity reaction(basophil)?
- binds to surface receptors
- *react w/ specific antigens
What happens when degranulation occurs(basophil)?
- Enzymes released in area
- contains histamine & heparin
What is the primary Lymphopoietic organs?
Bone marrow & thymus
What is the secondary lymphopoietic organs consist of?
Lymph nodes, spleen, tonsils
What is the second most frequently occuring WBC in peripheral blood?
Where do lymphocytes originate from?
from CFU-L in lymphopoietic organs
Which lymphocyte establish direct contact w/ foreign cell?
The T lymphocyte inhibits and kills what?
- inhibits growth of foreign cell
- kills foreign cell
T lymphocytes are involved in what?
- tumor suppresion
- graft rejection
What is another name for plasma cells?
End stage of B lymph maturation is what cell?
Plasmacytes originates from what?
antigenic stimulation of mature B lymphocytes
B lymph transform into what?
Plasmacytes are what type of producing cells?
A Mature monocyte's cytoplasm is abundant w/??
A mature monocyte's cytoplasm color and is?
- -pale blue-gray-ground glass appearance
- -fine pale red dust-like granules
- -vacuoles may be present
Monocytes exhibits what?
- -necrotaxis(attraction to dead or dying cells)
How long does monocytes spend in peripherial blood?
- approximately 14 hours
- -enters tissue
- -converts into macrophage
Hemoglobin A(HbA) is composed of what chains?
- 2 alpha
- 2 other chain
- *2 other chain determine the type of Hgb
What is the percentage of hemoglobin in adults for HbA?
What is Hemoglobin F also know as?
Hemoglobin F is composed what chains?
- 2 alpha chains
- 2 gamma chains
What is the percentage of adult hemoglobin F?
Platelets are fragments of what?
Megakaryocytes yields about how many platelets?
2000 to 4000
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