Eicosanoids = Arachidonic acid metabolites
Mediated by COX1 & COX 2 - leads to formation of prostaglandins. Results in a variety of mediators:
COX-3 recently discovered; plenty in brain; ? site of action for tylenol ?
IL-1: endothelial cell activation
IL-2: T-cell growth factor
TNF-a: a.k.a. cachectin
IL-1 & TNFa are the most important