Cytokines

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Author:
ehamm
ID:
112766
Filename:
Cytokines
Updated:
2011-10-27 21:37:04
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Cytokines
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Description:
Cytokines for exam 1
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  1. IFN-I
    • DC -> T cell
    • Initiation of adaptive response (signal 3)
    • antiviral
  2. IL-1
    • Monos, Macs -> T cells, Hepatocytes
    • T Cell activation
    • Fever
  3. IL-2
    • T Cells -> T Cells
    • T Cell proliferation
    • T Reg maintenance
  4. IL-3
    • T Cells, Thymic Epi cells -> HSC, NK, LAK cells
    • Works w/ IL-5, GM-CSF in hematopoiesis, B Cell development
  5. IL-4
    • TH2 -> B cells
    • Ig class switching (G and A)
    • B Cell proliferation
  6. IL-5
    • Th2, Masts -> Eos, B Cells
    • Eos hematopoiesis
    • Increase IgG1
  7. IL-6
    • T Cells, Macs, Endos -> B Cells, HSCs, hepatocytes
    • B Cell growth, differentiation, ig secretion
    • Acute phase response proteins
    • Inflammation
  8. IL-7
    • Bone Marrow, Thymic Stroma -> Pre-B, T
    • Proliferation
    • T Cell maintenance
  9. IL-10
    • TH2, B Cells, Macs -> TH1, NK Macs
    • Decrease APC function
    • Decrease TH1 cytokines
  10. IL-12
    • DC -> T cells
    • Initiation of adaptive immune response
    • TH1 polarization
  11. IL-15
    Maintains T memory cells
  12. IL-17
    • TH17
    • Proinflammatory
  13. IFN-Gamma
    • TH, CTL -> CTL, NK, Macs
    • Increase MHC expression
    • Increase APC
    • Decrease pathogen
  14. GM-CSF
    • Monos, T Cells -> Myelomonocytes, DCs
    • Stimulates marrow to produce more granulocytes, monos
  15. G-CSF
    • Fibroblasts, Mons -> Granulocyte precurses
    • Marrow increases PMNs
  16. TGF-Beta
    • CD4s, Monos -> T Cells, Dcs
    • Decrease mono activation
    • Decrease cell growth
    • Increase Treg, T17
  17. TNF-alpha
    • Macs, NK, T Cells -> Many
    • Inflammation
    • Endothelial Cell activation
    • Acute phase response

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