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azangari
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alkylating agents
- cell cycle non-specific
- nitrosureas can cross BBB
- mechlorethamine (nitrogen mustard)
- cyclophosphamide (cytoxan)
- ifosfamide (ifex)
- triethlenthip....(thiotepa)
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cyclophosphamide is the generic name for......
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ifosfamide is generic for......
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nitrosureas
dacarbazine, lomustine, carmustine
- can readily cross BBB
- considered alk. agents
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uses of alk. agents
- multiple myeloma
- leukemia
- lymphoma
can cause: leukemia, and severe BM suppression
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antitumor antibodies
cell cycle non-specific
- trick and bind to cell DNA ("as nucleic acid")
- destruct cell from inside out
ex: bleomycin, doxorubicin, mitomycin C, actinomycin D
come from fungus
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vincristine is generic for.......
oncovin
vinca alkaloid
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uses of anti tumor antibiotics
lymphomas, testicular cancers, whilm's tumor (kidney)
- mitomycin C known for myslosuppression
- doxorubicin- cardiac toxicity
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antimetabolites
- cell cycle specific
- destroy DNA and enzymes
- uses: H&N, breast, leukemia
- ex: 5-FU, methotrexate
- -risk of later showing leukemia (leukomagenesis)
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5-FU
- 5-flourouricil
- -alk agent or antimetabolite
- -radiozensitizer
- -radiation recall
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renal toxicity
cisplatin (misc. group)
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L-ASP
- L-Asperginase (Elspar)
- enzyme
- under misc. group
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misc. agents
- L-asperginase
- cisplatin
- hydroxyurea
- procarbazine
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vinca alkaloids used for
lymphomas and leukemias
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neurotoxicity
- vincristine/oncovin
- -vinca alkaloid
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hormones are used therapeutically to....
prohibit production of other hormones
- (estrogen vs. androgen/testosterone)
- breast, endometrial and prostate cancers
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tamoxifen (novaldex)
- popular anti-estrogen
- given to breast cancer patients
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