chemo

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Author:
azangari
ID:
112968
Filename:
chemo
Updated:
2011-10-29 13:38:32
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chemo
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chemo
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  1. alkylating agents
    • cell cycle non-specific
    • nitrosureas can cross BBB

    • mechlorethamine (nitrogen mustard)
    • cyclophosphamide (cytoxan)
    • ifosfamide (ifex)
    • triethlenthip....(thiotepa)
  2. cyclophosphamide is the generic name for......
    • cytoxan
    • (alk. agent)
  3. ifosfamide is generic for......
    • ifex
    • (alk. agent)
  4. nitrosureas
    dacarbazine, lomustine, carmustine

    • can readily cross BBB
    • considered alk. agents
  5. uses of alk. agents
    • multiple myeloma
    • leukemia
    • lymphoma

    can cause: leukemia, and severe BM suppression
  6. antitumor antibodies
    cell cycle non-specific

    • trick and bind to cell DNA ("as nucleic acid")
    • destruct cell from inside out

    ex: bleomycin, doxorubicin, mitomycin C, actinomycin D

    come from fungus
  7. vincristine is generic for.......
    oncovin

    vinca alkaloid
  8. uses of anti tumor antibiotics
    lymphomas, testicular cancers, whilm's tumor (kidney)

    • mitomycin C known for myslosuppression
    • doxorubicin- cardiac toxicity
  9. antimetabolites
    • cell cycle specific
    • destroy DNA and enzymes
    • uses: H&N, breast, leukemia
    • ex: 5-FU, methotrexate
    • -risk of later showing leukemia (leukomagenesis)
  10. 5-FU
    • 5-flourouricil
    • -alk agent or antimetabolite
    • -radiozensitizer
    • -radiation recall
  11. renal toxicity
    cisplatin (misc. group)
  12. L-ASP
    • L-Asperginase (Elspar)
    • enzyme
    • under misc. group
  13. misc. agents
    • L-asperginase
    • cisplatin
    • hydroxyurea
    • procarbazine
  14. vinca alkaloids used for
    lymphomas and leukemias
  15. neurotoxicity
    • vincristine/oncovin
    • -vinca alkaloid
  16. hormones are used therapeutically to....
    prohibit production of other hormones

    • (estrogen vs. androgen/testosterone)
    • breast, endometrial and prostate cancers
  17. tamoxifen (novaldex)
    • popular anti-estrogen
    • given to breast cancer patients

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