-
alkylating agents
- cell cycle non-specific
- nitrosureas can cross BBB
- mechlorethamine (nitrogen mustard)
- cyclophosphamide (cytoxan)
- ifosfamide (ifex)
- triethlenthip....(thiotepa)
-
cyclophosphamide is the generic name for......
-
ifosfamide is generic for......
-
nitrosureas
dacarbazine, lomustine, carmustine
- can readily cross BBB
- considered alk. agents
-
uses of alk. agents
- multiple myeloma
- leukemia
- lymphoma
can cause: leukemia, and severe BM suppression
-
antitumor antibodies
cell cycle non-specific
- trick and bind to cell DNA ("as nucleic acid")
- destruct cell from inside out
ex: bleomycin, doxorubicin, mitomycin C, actinomycin D
come from fungus
-
vincristine is generic for.......
oncovin
vinca alkaloid
-
uses of anti tumor antibiotics
lymphomas, testicular cancers, whilm's tumor (kidney)
- mitomycin C known for myslosuppression
- doxorubicin- cardiac toxicity
-
antimetabolites
- cell cycle specific
- destroy DNA and enzymes
- uses: H&N, breast, leukemia
- ex: 5-FU, methotrexate
- -risk of later showing leukemia (leukomagenesis)
-
5-FU
- 5-flourouricil
- -alk agent or antimetabolite
- -radiozensitizer
- -radiation recall
-
renal toxicity
cisplatin (misc. group)
-
L-ASP
- L-Asperginase (Elspar)
- enzyme
- under misc. group
-
misc. agents
- L-asperginase
- cisplatin
- hydroxyurea
- procarbazine
-
vinca alkaloids used for
lymphomas and leukemias
-
neurotoxicity
- vincristine/oncovin
- -vinca alkaloid
-
hormones are used therapeutically to....
prohibit production of other hormones
- (estrogen vs. androgen/testosterone)
- breast, endometrial and prostate cancers
-
tamoxifen (novaldex)
- popular anti-estrogen
- given to breast cancer patients
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