Anticoagulants

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Author:
lazzsant
ID:
113067
Filename:
Anticoagulants
Updated:
2011-10-29 21:45:50
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Anticoagulants
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Anticoagulants
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  1. Heparin

    Uses
    MOA
    Toxicity
    Uses: venous thrombosis, pulmonary embolism, AMI

    MOA: binds ATIII -> inhibition of coagulation proteases (IXa)

    SC (w/ Warfarin) or IV(emergency)

    Toxicity: Bleeding, hematuria, thrombocytopenia, osteoporosis
  2. Enoxaparin
    Low molecular weight heparin

    MOA: inhibits factor Xa
  3. Lepirudin

    Used
    MOA
    Toxicity
    recombinant of leech saliva protein

    Uses: heparin is contraindiacted b/c of induced thrombocytopenia

    MOA: inhibits thrombin

    Toxicity: bleeding, ab formation
  4. Warfarin

    Used
    MOA
    A/E
    Contra
    • Used: when need chronic anticoagulation
    • MOA: inhibits vit K reductase (in vivo only)

    • A/E: protein C inhibition -> skin & tissue necrosis
    • fetal toxicity

    • Antidote: vit. K
    • prothrombin complex
    • frozen plasma
    • whole blood

    • Contra: coagulopathy
    • aplastic anemia
    • leukemia
    • thrombocytopenia
    • peptic ulcer
  5. Drotrecogin- a

    Used
    MOA
    Recombinant protein C

    Used: anticoagulation & anti-inflammatory

    • MOA: binds Va & VIIIa
    • - inc fibrinolysis
    • suppress TNF-a, IL6, IL1
  6. Dabigatran Etexilate
    Used: stroke prevention in a-fib patient

    MOA: competitive inhibitor of thrombin
  7. Alteplase

    USED
    MOA
    A/E
    Contra
    • AKA reteplase, tenecteplase
    • (fibrinolytic)

    MOA: = TPA - plasminogen- plasmin- fibrin digestion

    • Used: MI (w/in 3 hours)
    • pulmonary thromboembolism
    • Ischemic stroke (alteplase)

    via IV

    • A/E: hermorrhage
    • systemic lytic state

    • Contra: aortic dissection
    • w/in 3 months closed head trauma/ ischemic stroke
  8. Antiplatelet drugs
    • Aspirin
    • clopidrogel
    • abciximab
  9. Clopidogrel
    Antiplatelet

    Used: prevent TIA & ischemic stroke

    MOA: irreversible block of ADP receptor on platelets -> no fibrinogen -> glycoprotein bond
  10. Abciximab
    Antiplatelet (ab)

    MOA: Fab binds noncompetitively to glycoprotein IIb/IIIa

    • Used:
    • coronary stent
    • unstable angina
  11. Clotter drugs
    • Vitamin K
    • thrombin
    • protamine sulphate
  12. vitamin K
    Phytonadione

    • MOA: counter warfarin toxicity
    • hemorrhage in newborn
    • hypoprothrombinemia
  13. Protamine sulphate
    Clotting drug

    from salmon sperm

    Used: Heparin counter

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