Immunology Chapter 5

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Immunology Chapter 5
2011-10-30 14:44:41
Immunology Chapter

Immunology Chapter 5
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  1. The complement system is:
    • a. A heat labile series of plasma proteins.
    • b. Composed of many proteinases
    • c. composed of three interrelated pathways.
    • d. all the above
  2. All the following are complement-controlling proteins excepts:
    • a. C1 (INH)
    • b. Factor I.
    • c. Factor H.
    • d. C3.
  3. Various cell types express surface membrane glycoproteins that react with one or more of the fragments of_________produced during complement activation and degradaton.
  4. all the following result from complement activation except:
    • a. Decreased cell susceptibility to phagocytosis.
    • b. Blood vessel dilation and increased vascular permeability.
    • c. Production of inflammatory mediators.
    • d. Cytolysis or hemolysis.
  5. Complete the following activation sequence of the classic complement pathway:
  6. which complement component is present in the greatest quantity in plasma?
  7. Arrange the three stages of the classic complement pathways in their corrct sequence.
    • - Recognition
    • -Enzymatic activation
    • -Membrane attack
  8. Fixation of the C1 complement component is related to each of the following factors except:
    • a. Molecular weight of the antibody.
    • b. The presence of IgM antibody.
    • c. The presence of most IgG subclasses.
    • d. Spatial constraints.
  9. At which stage does the complement system reach its full amplitude?
  10. Which of the following is not a component of the membrane attack complex?
  11. The final steps (c8 and C9) in complement activation lead to :
    Cell lysis.
  12. Select the appropriate pathway response:
    ____Activated by antigen-antibody complexes
    _____Generates a C3 convertase
    _____Activated by microbial and mammalian cell surfaces
  13. ______Terminates in a membrane attack complex
    • a. Classic pathway
    • b. Alternative pathway
    • c. Both a and b
  14. The alternate complement pathway is/can be:
    • a. Initiated by the formation of antigen-antibody reactions.
    • b. Predominantly a non-antibody-initiated pathway
    • c. Activated by factors such as endotoxins.
    • d. Both b and c
  15. which of the following conditions can be associated with hypercomplementemia?
    Myocardial infarction