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  1. ACE inhibitors

    -inhibit synthesis of Ang II
  2. Captoptril
    Mechanism: inhibit ACE, decreased synthesis of Ang II (also inhibits KKS)

    Indictations: HTN, HF, LV systolic dysfunction, MI, Renal protection

    Adverse Effects: cough, angioedema (rare), hypotensin, hyperkalemia, decreased renal function in patients with renal problems

    Other: contraindicated in pregnancy, prodrug converted in liver
  3. AT1 receptor blockers (ARBs)
    • -'sartans'
    • -block AT1 receptors
  4. Losartan
    Mechanism: blocks AT1 receptors

    Indications: HTN, HF/LV systolic dysfunction, MI, renal protetction

    Adverse Effects: hypotension, hyperkalemia, decreased renal function in patients with renal problems

    Other: contracindicated in pregnancy
  5. Direct renin inhibitors

    -Inhibit renin, decreased Ang II synthesis
  6. Aliskiren
    Mechanism: inhibits renin, leading to decreased Ang II synthesis

    Indications: HTN

    Adverse Effects: mild GI symptoms

    Other: contraindicated in pregnancy
  7. Kallikrein inhibitors
    Mechanism: inhibit plasma kallikrein

    Indications: hereditary angioedma (acute attacks)

    Adverse Effects: acute hypersensitivity reactions (including anaphylaxis), injection site reactions, headache, fatigue, nausea, diarrhea
  8. B2 receptor antagonists
    Mechanism: blocks B2 receptors

    Indications: Hereditary angioedema (acute attacks)

    Adverse Effects: injection site reactions, fever, dizziness, rash, increase hepatic enzyme levels
  9. ET receptor antagonists

  10. Bosentan
    Mechanism: blocks ET receptors

    Indications: Pulmonary HTN

    Adverse Effects: Hepatotoxicity, headache, nasopharyngitis, flushing, peripheral edema

    Other: contraindicated in pregnancy, must monitor LFTs, restricted distribution program

  11. SP Inhibitors
    Mechanism: block NK1 receptors

    Indications: chemotherapy-induced/post op nausea and vomiting

    Adverse Effects: fatigue, dizziness, diarrhea
  12. Synthetic BNP
    Mechanisms: stimulates NPRs (vasodilation, natriuresis)

    Indications: CHF (acute)

    Adverse Effects: hypotension, dizziness
Card Set:
2011-10-31 21:42:02
Peptide targeting

Pharmacological agents that target peptides
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