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bhugo85
on FreezingBlue Flashcards.
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Vit A - Fx
- Antioxidant
- Visual pigment
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Vit A - Excess
- Headache/Hepatomegaly
- Allopecia/Anorexia
- Really painful bones
- Dry skin/Drowsiness
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Vit B1 - Fx
- PDH
- αKDH
- Transketolase - key to test for in Thiamine deficiency
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Vit B1 - Deficiency
Beri Beri (alcoholics)
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Vit B2 - Fx
cofactor in redox
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Vit B2 - Deficiency
- Cheliosis
- Corneal vascularization
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B3 - Fx
constituent of NAD+ & NADP+
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B3 - Deficiency
- Pellagra ("DDD")
- Diarrhea
- Dementia
- Dermatitis
- **Death
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B5 - Fx
component of CoA syn. to form acetyl CoA for metabolic pathways
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B6 - Fx
used in transamination (detox of NH3) & decarboxylations
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B6 Deficiency
- Convulsions
- Peripheral neuropathy
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B12 - Fx
cofactor of homocysteine methyltransferase & methylmalonyl CoA mutase
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Homocysteine methyltransferase
Releases stored folate
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Methylmalonyl CoA Mutase
Source of succinyl CoA (substitue for acetyl CoA in TCA)
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B12 - Deficiency
macrocytic / megaloblastic anemia
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B9 - Fx
- converterd to THF
- synthesis of DNA & RNA
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B9 - Deficiency
macrocytic / megaloblastic anemia
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Biotin - Fx
- cofactor for caroylation enzymes
- (i.e. FA synthesis; acetyl coA to FA)
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Biotin - Deficiency
Maculosquamous Dermatitis (MCD)
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Vit C - Fx
- - Fe2+ absorption (keeps in Fe2+ state)
- - Used for Hydroylases in collagen syn.
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Vit C - Deficiency
Scurvy - decreased collagen type III (mesoderm)
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Vit D - Fx
- absorbs Ca2+
- increase bone reabsorption
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Vit D - Deficiency
- Rickets (kids)
- Osteomalacia (adults)
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Vit E - Fx
protects erythrocytes from ROS damage
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Vit E - Deficiency
- - Hemolytic anemia
- - Neurodysfunction
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Vit K - Fx
- catalyzes γ carboxylation
- of glutamic residues on clotting proteins
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Vit K - Deficiency
- - neonatal hemorrhage w/↑PT and PTT but normal
- bleeding time
- (-) by Warfarin
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