Antitubulin agents

What drugs are derived from the Madagascar periwinkle (Vinca rose)?
- Vinblastine
- Vincristine
- Vindesine
- Vinorelbine
How do the vinca derivatives work?

Induce depolymerization by binding to tubuline and blocking polymerization at the plus end.
True or False. Vinca alkaloids work on the S phase of the cell cycle

False. They are M-phase specific
Which is more neurotoxic vincristine or vinblastine? more myelosuppressive?

Vincristine is more neurotoxic but vinblastine is more myelosuppressive.
How must vinca alkaloids be administered?

IV. also vincristine is caustic so make sure no leakage
What are some mechanisms of resistance for vinca alkaloids?
- 1) Increased efflux via membrane drug transporters
- 2) Mutations in tubulin
How do paclitaxel and docetaxel work?

They both interfere with mitotic spindle and prevent its disassembly back into tubulin.
True or False. Similar to vinca alkaloids Paclitaxel and Docetaxel are M phase specific

True
How must paclitaxel and docetaxil be administered?

IV infusion
What can happen after IV infusion of paclitaxel in up to 5% of patients? How do you prevent this?
- Hypersensitivity reactions
- Prevented by premedicating with dexamethasone, diphenhydramine and H2 antagonist.
What is abraxane?
- Its reformulated paclitaxel basically. Contains that and albumin.
- It decreases risk of hypersensitivity reactions and no predmedication.
- Also has less myelosuppression

Author

jdonaldson

113564

Card Set

Antitubulin agents

Description

no more, please! noooooo

Updated

2011-11-01T03:29:17Z

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