Hematology: BOC Leukocytes

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love2006
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Hematology: BOC Leukocytes
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2011-11-01 18:13:15
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Hematology BOC Leukocytes
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Hematology: BOC Leukocytes
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  1. Which of the following condition is not associated with high
    incidence of leukemia?
    • a.
    • Paroxysmal nocturnal hemoglobinuria

    • b.
    • Fanconi anemia

    • c.
    • Aplastic anemia

    • d.
    • Megaloblastic anemia
  2. The M:E ratio in chronic myelocytic leukemia is usually:
    • a.
    • Normal

    • b.
    • High

    • c.
    • Low

    • d.
    • Variable
  3. Abnormalities found in erythroleukemia include:
    • a.
    • Rapid DNA synthesis

    • b.
    • Marrow fibrosis

    • c.
    • Megaloblastoid development

    • d.
    • Increased erythrocyte survival
  4. Neutropenia is not usually associated with:
    • a.
    • Viral infections

    • b.
    • Hodgkin disease

    • c.
    • Select antibiotics

    • d.
    • Chemotherapy
  5. Auer rods are most likely present in which of the following?
    • a.
    • Chronic myelocytic leukemia

    • b.
    • Myelofibrosis with myeloid metaplasia

    • c.
    • Erythroleukemia

    • d.
    • Acute myelocytic leukemia
  6. In an uncomplicated case of infectious mononucleosis, which of the following cells are affected?
    • a.
    • Erythrocytes

    • b.
    • Lymphocytes

    • c.
    • Monocytes

    • d.
    • Thrombocytes
  7. The atypical lymphocyte seen in the peripheral smear of patients with infectious mono is probably derived from which of the following?
    • a.
    • T lymphocytes

    • b.
    • B lymphocytes

    • c.
    • Monocytes

    • d.
    • Mast cell
  8. Which of the following cells is the atypical lymphocyte seen on the peripheral blood smear of patients with infectious mononucleosis?
    • a.
    • T lymphocytes

    • b.
    • B lymphocytes

    • c.
    • Monocytes

    • d.
    • Mast cell
  9. The disease most frequently present in patients with
    atypical lymphocytosis and persistently negative tests is:
    • a.
    • Toxoplasmosis

    • b.
    • Cytomegalovirus (CMV) infection

    • c.
    • Herpes virus infection

    • d.
    • Viral hepatitis
  10. Which of the following is associated with pseudo-Pelger-Huet anomaly?
    • a.
    • Aplastic anemia

    • b.
    • Iron deficiency anemia

    • c.
    • Myelogenous leukemia

    • d.
    • Chediak-higashisyndrome
  11. Increased numbers of basophils are often seen in:
    • a.
    • Acute infections

    • b.
    • Chronic myelocytic leukemia

    • c.
    • Chronic lymphocytic leukemia

    • d.
    • Erythroblastosis fetalis
  12. In chronic myelocytic leukemia , blood histamine concentration tend to reflect the
    • a.
    • Number of platelets present

    • b.
    • Serum uric acid concentrations

    • c.
    • Number of basophils present

    • d.
    • The total number of granulocytes
  13. Biochemical abnormalities characteristic of polycythemia vera include
    • a.
    • Increased
    • serum B12 binding capacity

    • b.
    • Hypouricemia

    • c.
    • Hypohistaminemia

    • d.
    • Decreased leukocyte alkaline phosphatase activity
  14. 50%-90% myeloblasts in a peripheral blood in typical of which of the following?
    • a.
    • Chronic myelocytic leukemia

    • b.
    • Myelofibrosis with myeloid metaplasia

    • c.
    • Erythroleukemia

    • d.
    • Acute myelocytic leukemia
  15. The M:E ratio in acute myelocytic leukemia is usually
    • a.
    • Normal

    • b.
    • High

    • c.
    • Low

    • d.
    • Variable
  16. Which of the following is most closely associated with
    chronic myelomonocytic leukemia?
    • a.
    • Philadelphia chromosome

    • b.
    • Disseminated intravascular coagulation

    • c.
    • Micromegakaryocytes

    • d.
    • Lysozymuria
  17. The absence of intermediate maturing cells between the blastand mature neutrophil commonly seen in acute myelocytic keukemia and myelodysplastic syndromes is called:
    • a.
    • Subleukemia

    • b.
    • Aleukemic leukemia

    • c.
    • Leukemic hiatus

    • d.
    • Leukemoid reaction
  18. Which of the following is most closely associated with
    chronic myelogenous leukemia?
    • a.
    • Ringed sideroblasts

    • b.
    • Disseminated intravascular coagulation

    • c.
    • Micromegakaryocytes

    • d.
    • Philadelphia chromosome
  19. A block in the differentiation or maturation of, and an
    accretion of immature hematopoietic progenitors is a hallmark of:
    • a.
    • Chronic lymphocytic leukemia

    • b.
    • Myeloproliferative disease

    • c.
    • Polycythemia vera

    • d.
    • Acute myelogenous leukemia
  20. All stage of neutrophils are most likely to be seen in the peripheral blood of a patient with:
    • a.
    • Chronic myelocytic leukemia

    • b.
    • Myelofibrosis with myeloid metaplasia

    • c.
    • Erythroleukemia

    • d.
    • Acute myelocytic leukemia
  21. All of the following conditions are myeloproliferative disorders except:
    • a. Myelocytic leukemiab.
    • Lymphocytic leukemiac.
    • Polycythemia verad.
    • Idiopathic thrombocythemia
  22. A patient has a tumor that concentrates erythropoietin. He is most likely to have which of the following types of polycythemia?
    • a.
    • Polycythemia vera

    • b.
    • Polycythemia, secondary to hypoxia

    • c.
    • Benign familial polycythemia

    • d.
    • Polycythemia associated with renal disease
  23. Which of the following types of polycythemia is most often associated with emphysema?
    • a.
    • Polycythemia vera

    • b.
    • Polycythemia, secondary to hypoxia

    • c.
    • Relative polycythemia associated with
    • dehydration

    • d.
    • Polycythemia associated with renal disease
  24. Hemorrhage in polycythemia vera is the result of :
    • a.
    • Increased plasma viscosity

    • b.
    • Persistent thrombocytosis

    • c.
    • Splenic sequestration of platelets

    • d.
    • Abnormal platelet function
  25. A patient diagnosed with polycythemia vera 5 years ago now has a normal hematocrit, decreased hemoglobin and microcytic, hypochromic red
    cells. What is the most probable cause for the current blood situation?
    • a.
    • Phlebotomy

    • b.
    • Myelofibrosis

    • c.
    • Preleukemia

    • d.
    • Aplastic anemia
  26. A patient has been treated for polythemia vera for several years. His blood smear now shows:
    Oval macrocytes
    Howell-Jolly bodies
    hypersegmented neutrophils
    large, agranular platelets

    The most probable cause of this blood picture is:
    • a.
    • Iron deficiency

    • b.
    • Alcoholism

    • c.
    • Dietary B12 deficiency

    • d.
    • Chemotherapy
  27. In infectious mononucleosis, lymphocytes tend to be:
    • a.
    • Small with little cytoplasm

    • b.
    • Normal

    • c.
    • Decreased in number

    • d.
    • Enlarged and indented by surrounding structures
  28. In comparison to malignant lymphoma cells, reactive
    lymphocytes
    • a.
    • Have a denser nuclear chromatin

    • b.
    • Are known to be T cells

    • c.
    • Have more cytoplasm and more mitochondria

    • d.
    • Are morphologically more variable throughout the
    • smear
  29. Which of the following is true of acute lymphoblastic
    leukemia?
    • a.
    • Occurs most commonly in children 1-2 years of
    • age

    • b.
    • Patient is asymptomatic

    • c.
    • Massive accumulation of primitive lymphoid-appearing cells in bone marrow occurs

    • d.
    • Children under 1 year of age have a good
    • prognosis
  30. A 50 year-old woman who has been receiving busulfan for three years for chronic myelogenous leukemia become anemic. Laboratory tests
    reveal:
    Thrombocytopenia
    Many peroxidase-negative blast cells in the peripheral blood
    Bone marrow hypercellular in blast transformation
    Markedly increased bone marrowTdT

    which of the following complications is this patient most likely to have?
    • a.
    • Acute lymphocytic leukemia

    • b.
    • Acute myelocytic leukemia

    • c.
    • Acute myelomonocytic leukemioa

    • d.
    • Busulfan toxicity
  31. The most common form of childhood leukemia is:
    • a.
    • a cute lymphocytic

    • b.
    • acute granulocytic

    • c.
    • acute monocytic

    • d.
    • chronic granulocytic
  32. Chronic lymphocytic leukemia is defined as a(n):
    • a.
    • malignancy of the thymus

    • b.
    • accumulation of prolymphocytes

    • c.
    • accumulation of hairy cells in the spleen

    • d.
    • accumulation of monoclonal B cells with a block
    • in cell maturation
  33. Which of the following is not a characteristic usually
    associated with hairy cell leukemia?
    • a.
    • Pancytopenia

    • b.
    • Mononuclear cells with ruffled edges

    • c.
    • Splenomegaly

    • d.
    • Increased resistance to infection
  34. Morphologic variants of plasma cells do not include:
    • a.
    • Flame cells

    • b.
    • Morula cells

    • c.
    • Grape cells

    • d.
    • Gaucher cells
  35. Of the following, the disease most closely associated with
    cytoplasmic granule fusion is:
    • a.
    • Chediak- higashi syndrome

    • b.
    • Pelger-huet anomaly

    • c.
    • May-hegglin anomaly

    • d.
    • Alder-reilly anomaly
  36. Which of the following anomalies is an autosomal dominant disorder characterized by irregularly-sized inclusions in polymorphonuclear neutrophils, abnormal giant platelets and often thrombocytopenia?
    • a.
    • Chediak- higashi syndrome

    • b.
    • Pelger-huet anomaly

    • c.
    • May-hegglin anomaly

    • d.
    • Alder-reilly anomaly
  37. Of the following, the disease most closely associated with granulocyte hyposegmentation is:
    • a.
    • Chediak- higashi syndrome

    • b.
    • Pelger-huet anomaly

    • c.
    • May-hegglin anomaly

    • d.
    • Alder-reilly anomaly
  38. Which of the following cell types is characteristic of
    Pelger-Huet anomaly is the:
    • a.
    • Band form

    • b.
    • Pince-nez form

    • c.
    • Normal neutrophil

    • d.
    • Myelocyte
  39. Which of the following is associated with Chediak-Higashi syndrome?
    • a.
    • Membrane defect of lysosomes

    • b.
    • Dohle bodies and giant platelets

    • c.
    • Two-lobed neutrophils

    • d.
    • Mucopolysaccharidosis
  40. Which of the following is associated with Alder-Reilly
    inclusion?
    • a.
    • Membrane defect of lysosomes

    • b.
    • Dohle bodies and giant platelets

    • c.
    • Two-lobed neutrophils

    Mucopolysaccharidosis
  41. Which of the following is associated with May-Hegglin
    anomaly?
    • a.
    • Membrane defect of lysosomes

    • b.
    • Dohle bodies and giant platelets

    • c.
    • Two-lobed neutrophils

    • d.
    • Mucopolysaccharidosis
  42. A differential was performed on an asymptomatic patient. The differential included 60% neutrophils; 55 of which had 2 lobes and 5 had 3 lobes. There were no other abnormalities. This is consistent with which of the following anomalies?
    • a.
    • Pelger-Huet

    • b.
    • May-Hegglin

    • c.
    • Alder-Reilly

    • d.
    • Chediak-Higashi
  43. The cytoplasmic abnormality of the white blood cell of
    Alder-Reilly anomaly is found in the :
    • a.
    • Endoplasmic reticulum

    • b.
    • Lysosomes

    • c.
    • Mitochondria

    • d.
    • Ribosomes
  44. Of the following , the disease most closely associated with mucopolysacharidosis is:
    • a.
    • Pelger-Huet anomaly

    • b.
    • Chediak-higashi syndrome

    • c.
    • Gaucher disease

    • d.
    • Alder-Reilly anomaly
  45. Of the following, the disease most closely associated with
    glucocerebrosidase deficiency is:
    • a.
    • Gaucher disease

    • b.
    • Chediak-higashi syndrome

    • c.
    • Pelger-huet anomaly

    • d.
    • May-hegglin anomaly
  46. Of the following, the disease most closely associated with
    pale blue inclusion in granulocytes and giant platelets is:
    • a.
    • Gaucher disease

    • b.
    • Alder-Reilly anomaly

    • c.
    • May-Hegglin anomaly

    • d.
    • Pelger-Huet anomaly

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