Chapter 10

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Author:
lisa0615
ID:
114127
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Chapter 10
Updated:
2011-11-02 22:07:14
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Vocabulary
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Vocabulary
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  1. the substantial degraduation of an orally administered drug caused by enzyme metabolism in the liver before the drug reaches the systemic circulation
    first-pass metabolism
  2. the increase in hepatic enzyme activity that results in greater metabolism of drugs
    enzyme induction
  3. the study of the factors associated with drug products and physiological processes, and the resulting systemic concentrations of drugs
    biopharmaceutics
  4. the comparison of bioavailability between two dosage forms
    bioequivalency
  5. the relative amount of an administered dose that reaches the general circulation and the rate at which this occurs
    bioavailability
  6. water repelling; cannot associate with water
    hydrophobic
  7. capable of associating with or absorbing water
    hydrophilic
  8. the blood filtering process of the nephron
    glomerular filtration
  9. the time a drug will stay in the stomach before it is emptied into the small intestine
    gastric emptying time
  10. the decrease in hepatic enzyme activity that results in reduced metabolism of drugs
    enzyme inhibition
  11. a complex protein that catalyzes chemical reactions
    enzyme
  12. the transfer of drugs and their metabolites from the liver to the bile in the gall bladder, then into the intestine, and then back into circulation
    enterohepatic cycling
  13. the process of metabolism and excretion
    elimination
  14. the time the drug concentration is above the MEC
    duration of acton
  15. a term sometimes used to refer to all the ADME processes together
    disposition
  16. when different molecules associate or attach to each other
    complexation
  17. the movement of drugs from an area of lower concentration to an area of higher concentration; requires cellular energy
    active transport
  18. the movement of drug from the dosage formulation to the blood
    absorption
  19. drugs that activate receptors to accelerate or slow normal cellular functions
    agonists
  20. drugs that bind with receptors but do not activate them
    antagonists
  21. fat-like substance
    lipoidal
  22. the attachment of a drug molecule to a protein, effectively making the drug inactive
    protein binding
  23. the cellular material which interacts with the drug
    receptor
  24. the movement of drugs from an area of higher concentration to lower concentration
    passive diffusion
  25. the characteristic of a drug that makes its action specific to certain receptors
    selective (action)
  26. the location where an administered drug produces an effect
    site of action
  27. the blood concentration needed for a drug to produce a response
    minimum effective concentration (MEC)
  28. the time MEC is reached and the response occurs
    onset of action
  29. a drug's blood concentration range between its MEC and MTC
    therapeutic window
  30. the upper limit of the therapeutic window
    minimum toxic concentration (MTC)
  31. the substance resulting from the body's transformation of an administered drug
    metabolite
  32. the functional unit of the kidney
    nephron
  33. drug products that contain identical amounts of the same active ingredient in the same dosage form
    pharmaceutical equivalent
  34. pharmaceutical equivalents that produce the same effects in patients
    therapeutic equivalent
  35. drug products that contain the same active ingredient but not necessarily in the same salt form, amount, or dosate form
    pharmaceutical alternative

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