Intro to Pharmacology

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Author:
jknell
ID:
114499
Filename:
Intro to Pharmacology
Updated:
2011-11-04 15:58:24
Tags:
pharmacology basics
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Description:
intro to pharm, drug receptor interactions (lectures 2 and 3)
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  1. Pharmacodynamics
    the effect of drugs on the body
  2. Pharmacokinetics
    the effect of the body on drugs
  3. Law of Mass Action
    • 
    • Kd = k-1/k1
  4. EC50
    • the drug concentration at which the effect is 1/2 of the maximum
  5. Kd
    • -equilibrium dissociation constant
    • -drug concentration at which receptor occupancy is 1/2 maximum

  6. Receptor Occupancy
    • -fractional saturation
    • RO = DR/Rtotal = DR/R+DR

    when D = Kd then R = DR and DR/Rtotal = 0.5
  7. Partial agonist
    Has only a partial response (due to shorter occupancy time)
  8. Inverse agonist
    Binds the R and causes a decreased basal response
  9. Competitive Antagonist
    • -binds the same site as the Drug
    • -if you increase the concentration of the drug you can still have maximal signaling
  10. Noncompetitive Antagonist
    • -binds to a different site on the receptor, the drug binds it's normal site but can't have maximal signaling
    • Kd remains unchanged but maxiumum response is decreased by 1/(1+I/Ki)
  11. Mixed antagonist
    binds to a separate site but modulates the ability of the agonist to bind
  12. Physiological Antagonist
    Drug that antagonized the effect of another druge by inducing an opposing physiological response
  13. Irreversible Antagonist
    • irreversible binding
    • -law of mass action does not apply
  14. Allosteric Activator
    binds to site independent of agonist binding site and enhances the activity of the agonist
  15. Potency
    • the does that causes a given effect
    • -the most potent has the lowest EC50 (A)
  16. Efficacy
    • the dose that gives the maximal response (B, C, D)
  17. ED50
    mean effective does: produced effect in 50% of patients in a population
  18. LD50
    mean lethal dose
  19. Therapeutic Index
    LD50/ED50

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