Antifungals

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Author:
pszurnicki
ID:
114773
Filename:
Antifungals
Updated:
2011-11-06 00:15:07
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Antifungals
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Antifungals
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  1. Rx for systemic fungal infection
    candida, cryptococcus, histoplasmosis, coccidomycosis
    aspergillosis?
    IV amphotericin B
  2. MOA of amphotericin B?
    binds to ergosterol and forms pores
  3. S/E of amphotericin b?
    nephrotoxicity--dose dependent
  4. Flu like symptoms with amphotercicin B can be treated how?
    • give antipyretic
    • antihistamine
    • anit emetic
  5. What is intrathecal administration?
    infusion into the subarachnoid space
  6. Rx of resistant cryptococcus/candidiasis?
    Amphotericin B + flucytosine
  7. Use of Nystatin?
    • topical rx of candidiasis
    • too toxic for systemic use
  8. Resistance to amphotercin B?
    decrease ergesterol levels
  9. 2 precursors to ergesterol?
    squalene-->lanosterol
  10. MOA of azoles?
    inhibits ergesterol synthesis by stopping fungal cyt p450
  11. Which azoles are used for topical infecions?
    • clotrimazole
    • miconazole
  12. Which azole produces gyncomastia and decreased libido bc it inhibits desmolase?
    ketoconazole
  13. Azole with CNS penetrance i.e cryptococcus infection?
    fluconazole
  14. Which azole doesnt cross BBB?
    Itraconazole
  15. Azoles block what enzyme?
    14 demethylase
  16. MOA of Grisefulvin?
    inhibition of mitotic spindle formation
  17. Rx of tinea cruris?
    Griseofulvin
  18. S/E of griseofulvin?
    • acute intermittent porphyria
    • disulfiram like rx
  19. MOA of terbinafine?
    inhibits squalene epoxidase
  20. Rx of onychomycosis?
    Terbinafine
  21. Which of the antifungals elevate liver enzymes?
    Terbinafine
  22. MOA of Flucytosine?
    inhibits thymidylate synthase by forming 5 Fluorocytosine
  23. Use of Flucytosine?
    with amphotericin B in severe systemic cadidiasis infections
  24. S/E of Flucytosine?
    • BM supression
    • GI upset
    • Thrombocytopenia
    • Leukopenia

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