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Rx for systemic fungal infection
candida, cryptococcus, histoplasmosis, coccidomycosis
IV amphotericin B
MOA of amphotericin B?
binds to ergosterol and forms pores
S/E of amphotericin b?
Flu like symptoms with amphotercicin B can be treated how?
- give antipyretic
- anit emetic
What is intrathecal administration?
infusion into the subarachnoid space
Rx of resistant cryptococcus/candidiasis?
Amphotericin B + flucytosine
Use of Nystatin?
- topical rx of candidiasis
- too toxic for systemic use
Resistance to amphotercin B?
decrease ergesterol levels
2 precursors to ergesterol?
MOA of azoles?
inhibits ergesterol synthesis by stopping fungal cyt p450
Which azoles are used for topical infecions?
Which azole produces gyncomastia and decreased libido bc it inhibits desmolase?
Azole with CNS penetrance i.e cryptococcus infection?
Which azole doesnt cross BBB?
Azoles block what enzyme?
MOA of Grisefulvin?
inhibition of mitotic spindle formation
Rx of tinea cruris?
S/E of griseofulvin?
- acute intermittent porphyria
- disulfiram like rx
MOA of terbinafine?
inhibits squalene epoxidase
Rx of onychomycosis?
Which of the antifungals elevate liver enzymes?
MOA of Flucytosine?
inhibits thymidylate synthase by forming 5 Fluorocytosine
Use of Flucytosine?
with amphotericin B in severe systemic cadidiasis infections
S/E of Flucytosine?
- BM supression
- GI upset
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