ADT Exam 2

Card Set Information

Author:
Rx2013
ID:
114915
Filename:
ADT Exam 2
Updated:
2011-11-06 16:06:12
Tags:
Monoclonal Antibodies
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Description:
Monoclonal Antibodies
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  1. Monoclonal antibodies
    • proteins made by the body's immune system
    • directed against antigens
  2. Fab fragment
    determines specificity
  3. Fc represents
    constant portion
  4. Chimeric mAbs
    • human IgG genes in the Fc region
    • mouse genes in the Fab portion
  5. Most mAbs are ____ weight
    • 150 kd
    • 150,000 g/mol
  6. Volume of distribution of monocolnals
    • not usually more than 2x the plasma water
    • 5.7-6 Liters
  7. Where mAbs are found
    cannot bind to tissues because it cant get out of the vasculature
  8. names ending with momam
    • pure mouse antibody
    • run risk of inducing anti-mouse antibodies rendering the drug ineffective
  9. ximab
    • chimeric antibody
    • Fab region is mouse
    • Fc region is human
  10. zumab
    • humanized antibodies
    • antigenic amino acids
  11. antigen binding region
    • Y top portion
    • N-terminal end
  12. chrystalizable portion
    • Y bottom portion
    • C-terminal end
  13. murine IgG
    omab
  14. human/murine chimeric IgG
    ximab
  15. humanized IgG
    zumab
  16. human IgG
    umab
  17. Principle behing mAb therapy
    stimulate patient's immune system to attack malignant tumor cells and prevent tumor growth by blocking specific cell receptors
  18. Half lives of mAbs
    minutes
  19. Abciximab
    • reopro
    • chimeric
    • IIb/IIIa inhibitor
    • Cardiovascular
  20. Bevacizumab
    • Avastin
    • humanized
    • vascular endothelial growth factor
    • colorectal cancer
  21. Efalizumab
    • Raptiva
    • humanized
    • psoriasis
  22. Infliximab
    • remicade
    • chimeric
    • inhibits TNF alpha signaling
    • auto-immune disorders
  23. Natalizumab
    • humanized
    • T cell
    • MS
  24. Omalizumab
    • xolair
    • humanized
    • targets IgE
    • asthma therapy
  25. Reopro and lucentis MW
    about 50 kd
  26. Trastuzumab
    • herceptin
    • humanized
    • ErbB2
    • breast cancer

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