ADT Exam 2

• proteins made by the body's immune system
• directed against antigens

determines specificity

constant portion

• human IgG genes in the Fc region
• mouse genes in the Fab portion

• 150 kd
• 150,000 g/mol

• not usually more than 2x the plasma water
• 5.7-6 Liters

cannot bind to tissues because it cant get out of the vasculature

• pure mouse antibody
• run risk of inducing anti-mouse antibodies rendering the drug ineffective

• chimeric antibody
• Fab region is mouse
• Fc region is human

• humanized antibodies
• antigenic amino acids

• Y top portion
• N-terminal end

• Y bottom portion
• C-terminal end

omab

ximab

zumab

umab

stimulate patient's immune system to attack malignant tumor cells and prevent tumor growth by blocking specific cell receptors

minutes

• reopro
• chimeric
• IIb/IIIa inhibitor
• Cardiovascular

• Avastin
• humanized
• vascular endothelial growth factor
• colorectal cancer

• Raptiva
• humanized
• psoriasis

• remicade
• chimeric
• inhibits TNF alpha signaling
• auto-immune disorders

• humanized
• T cell
• MS

• xolair
• humanized
• targets IgE
• asthma therapy

about 50 kd

• herceptin
• humanized
• ErbB2
• breast cancer