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ADT Exam 2
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Monoclonal antibodies
proteins made by the body's immune system
directed against antigens
Fab fragment
determines specificity
Fc represents
constant portion
Chimeric mAbs
human IgG genes in the Fc region
mouse genes in the Fab portion
Most mAbs are ____ weight
150 kd
150,000 g/mol
Volume of distribution of monocolnals
not usually more than 2x the plasma water
5.7-6 Liters
Where mAbs are found
cannot bind to tissues because it cant get out of the vasculature
names ending with momam
pure mouse antibody
run risk of inducing anti-mouse antibodies rendering the drug ineffective
ximab
chimeric antibody
Fab region is mouse
Fc region is human
zumab
humanized antibodies
antigenic amino acids
antigen binding region
Y top portion
N-terminal end
chrystalizable portion
Y bottom portion
C-terminal end
murine IgG
omab
human/murine chimeric IgG
ximab
humanized IgG
zumab
human IgG
umab
Principle behing mAb therapy
stimulate patient's immune system to attack malignant tumor cells and prevent tumor growth by blocking specific cell receptors
Half lives of mAbs
minutes
Abciximab
reopro
chimeric
IIb/IIIa inhibitor
Cardiovascular
Bevacizumab
Avastin
humanized
vascular endothelial growth factor
colorectal cancer
Efalizumab
Raptiva
humanized
psoriasis
Infliximab
remicade
chimeric
inhibits TNF alpha signaling
auto-immune disorders
Natalizumab
humanized
T cell
MS
Omalizumab
xolair
humanized
targets IgE
asthma therapy
Reopro and lucentis MW
about 50 kd
Trastuzumab
herceptin
humanized
ErbB2
breast cancer
Author
Rx2013
ID
114915
Card Set
ADT Exam 2
Description
Monoclonal Antibodies
Updated
11/6/2011, 9:06:12 PM
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