ADT Exam 2

Card Set Information

Author:
Rx2013
ID:
114931
Filename:
ADT Exam 2
Updated:
2011-11-06 16:46:33
Tags:
PK monoclonals
Folders:

Description:
PK for monoclonals
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user Rx2013 on FreezingBlue Flashcards. What would you like to do?


  1. Half life with SC injection vs IV
    sub Q half life is much longer (10 hrs vs 68 min)
  2. Diffusion of peptides and proteins across capillary endothelial cells is determined by
    • size
    • shape
    • charge
    • structural and chemical characteristics of capillaries
  3. Elimination of proteins from the blood
    • cytokines taken up by the liver and filtered by the kidney
    • peptidases and proteases eliminate protein drugs
  4. three types of capillary endothelia
    • discontinuous
    • fenestrated
    • continuous
  5. discontinuous endothelia
    • liver, spleen and bone marrow
    • frequent large gaps >100 nm
    • no endothelial cells or basement membrane
  6. fenestrated capillary endothelia
    • glomeruli, intestines, tissues with rapid fluid movement
    • 60-80 nm opening between cells
    • heparin laden membrane
    • devoid of lipid
  7. continuous endothelia
    • majority of capillary surface area
    • no gaps and few fenestrations
    • brain, lung, muscle, connective tissue
    • no gaps in brain (BBB)
  8. Cell types of the liver
    • hepatocytes (78%)
    • endothelial cells (3%)
    • kupffer cells (2%)
    • fat storing cells (1.5%)
    • sinusoids (11%)
    • space of disse (5%)
    • Bilary tree (0.5%)
  9. two processes of uptake
    • receptor mediated endocytosis
    • nonselecive pinocytosis
  10. Up to ___% of proteins and peptides in the plasma with molecular weights less than 25KD are cleared in a single pass unless protein bound
    50%
  11. The glomerulus is ____ charged
    negatively
  12. Peptides and small proteins (less than ____kd) pass into the ultrafiltrate almost like inulin.
    5kd
  13. protein/inulin clearance ratio
    • rangest from 0 to 1
    • 1= small peptides
    • 0=albumin
  14. glomerular sieving coefficient
    • 0=albumin
    • 0.5 anions
    • 0.8 cations and 20kd
  15. proteins not found in the urine are metabolized by___ if low molecular weight
    brush border enzymes
  16. proteins not found in urine are metabolised by ____ if high MW
    lyzosymes after endocytosis
  17. macromolecules bound to proteins to increase plasma half life
    • dextran
    • peg
    • polystyrenemaleic acid copolymer
    • albumin
    • monoclonal antibodies
  18. an example of conjugating proteins and macromolecules
    • l asparaginase
    • enzyme with anti tumor effects
    • bound to PEG to reduce anaphylactic reactions and increase half life in the plasma
  19. Pegylation of proteins and peptides
    • covalent binding of PEG to proteins or peptides
    • increase stability
    • increases water solubility
    • increases MW

What would you like to do?

Home > Flashcards > Print Preview