ADT Exam 2

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Author:
Rx2013
ID:
114941
Filename:
ADT Exam 2
Updated:
2011-12-06 10:11:13
Tags:
pharmacogenetics
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Description:
pharmacogenetics
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  1. Approximately ___% of caucasians are PMs
    7%
  2. Legal basis of product labels of drugs that may be hazardous for PMs
    labeling has to describe evidence and identify specific tests needed for selection and monitoring patients who need the drug
  3. Pharmacogenetics
    • study of how variant forms of human genes contribute to inter-individual variability in drug response
    • right drug for the right patient
  4. Genetic polymorphisms of drug metabolism
    • inherited
    • monogenic
    • observed only with drug challenge
    • not rare
  5. pharmacogenomics
    • characterization of the genome wide response to small molecular molecules administered with therapeutic intent
    • right drug for right disease
    • study of how interacting genes determine individual response to drugs
  6. SNP
    single nucleotide polymorphism
  7. SNV
    • single nucleotide variation
    • includes SNPs, single nucleotide insertion/deletions
  8. Haplotype
    • group of SNPs inherited together as a block
    • AGT vs GAC
  9. Pharmacogenetics is clinically important when
    • the defective drug metabolism pathway is responsible for most of the elimination of the drug
    • drug displays a NTI
  10. Gene of CYP2D6
    CYP (cytochrome P 450)
  11. Sub family of CYP2D6
    2D
  12. Isoform of CYP2D6
    2D6
  13. Allele of gene CYP2D6*4
    • *4
    • *1 is the reference gene
  14. Poor metabolizers
    • two inactive forms (alleles) of the CYP2D6 gene
    • 1% of asians but overal lower activity than caucasians
  15. CYP2D6 *1 and *2
    • active
    • score is 1
  16. CYP2D6 *9, *10, *17 and *29
    • score is 0.5
    • some activity
  17. CYP2D6 *3-*8
    • no activity
    • score is 0

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