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NSAIDs essentially block TxA? or PGI?
inhibition of TxA is more pronounced--thus used to inhibit protein aggregation in MI
What are the eiconosaoids?
What FA gives rise to Eiconosoids?
What converst phospholipds to arachidonic acid?
What enzyme converts arachidonic acid to endoperoxides?
What enzyme converts arachidonic acid to Hydroperoxides?
What drug inhibits Lipooxygenase?
What drugs inhibits binding of LTD4 to receptors?
What drug inhibits Cyclooxygenase enzyme?
- Aspiring- irriversibly
What inhibits phopholipase A2 enzyme?
Role of PGE1?
- maintainenance of GI mucosa via
- 1. increasing secretion of GI mucosa
- 2. decreasing acid secretion
Rx of NSAID induced ulcers?
PGF2 analog used for glaucoma?
What PGE1 maintains PDA?
Which Prostaglandin analog is Abortificient?
PGE2 do what?
- Uterine contraction/cervical contraction
PGF2 does what?
- Uterine and BRONCHIAL CONTRACTION
What prostaglandins are elevated in Dysmenorrhea?
What Prostaglandin analogs are abortificient?
- PGF2--Carboprost and Dinoprost
Role of PGI2?
- inhibit platelet aggregation
PGI2 synthetic analog used for pulmonary HTN?
What COX activates PGI2?
Cox2-so cox2 inhibitor i.e celexocib increase platelet aggregation and you get MI
Role of TX2?
- opposite of PGI2 i.e
- vasodilation, bronchoconstriction
- promote platelet aggregation
TxA work thru what g protein secondary signalling molecule?
PGI2 works thru what g protein secondary signalling molecule?
- phospholipase c--> IP3-->high Ca---platelet aggregation
- activated camp..which sequesters Ca--decrease platelet aggregation
Role of LTB4?
Role of LTA4, LTD4, LTC4?