IBD 1

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Author:
jonpnass
ID:
115969
Filename:
IBD 1
Updated:
2011-11-10 18:27:28
Tags:
IBD
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Description:
IBD questions
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  1. PANCA

    what are the characteristics of this marker
    very sensitive for IBD (fewer than 5 % of people that have this are IBD negative)

    • 2/3 UC
    • 1/4 crohns
  2. ASCA
    1/2 to 1/3 patients with this have CD. Very specific for CD
  3. OmpC
    sensitive for IBD

    more specific for CD
  4. C-Bir1
    • specific for CD
    • but only present on 50% of patients with crohns
  5. Which marker can predict the chances of having pouchitis.
    Panca

    Likely because of an increase in the level of chronic pouchitis in PANCA + patients
  6. which marker can predict higher number of surgeries
    ASCA
  7. how much does ulcerative colitis reduce fertility
    it does not
  8. how much does having uc and having a pouch procedure reduce fertility
    80%
  9. In Crohns disease how is fertility affected
    pelvic inflammation can lead to fallopian tube scarring.
  10. IgG1 monoclonal antibody that is human murine hybrid
    inflimimab
  11. fully human monoclonal antibody
    adalimumab
  12. list risk factors for cancer in u/c patients
    • pan colonic disease
    • duration of disease
    • Backwash ileitis
  13. which serum marker tends to predict that crohns disease will be limited to the colon?
    PANCA
  14. how much does NOD2/CARD15 gene affect rates of Crohns disease
    • one copy- 3 fold increas in CD risk
    • two copies of the gene- 10-40 fold increase
  15. IBD and joint disease
    how are they related
    • usually large joints and asymmetric.
    • joint problems are more active when bowel sx are active
  16. extraintestinal manifestations of IBD that parallel disease activity
    • E.nodosum
    • arthralgias,
    • uveitis,
    • and
    • DVT
  17. extraintestinal manifestations of IBD that don't parallell bowel activity
    ankylosing spondylitis.
  18. what serum marker needs to be checked prior to initiating cyclosporin therapy
    • cholesterol.
    • the dose needs to be adjusted if serum cholesterol is less than 100
  19. Clinical predictors for pouchitis
    • extraintestinal manifestations,
    • backwash ileitis
    • need for high dose steroids prior to surgery
  20. Lifetime risk of pouchitis in patients with IPAA
    50%

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