Asthma Drugs

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Author:
pszurnicki
ID:
116134
Filename:
Asthma Drugs
Updated:
2011-11-13 21:58:19
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Asthma Drugs
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Asthma Drugs
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  1. Short acting Beta 2 agonist for emergency management of asthma?
    Albuterol
  2. 3 Short acting Beta 2 agonists used for asthma?
    • Albuterol
    • Metaproterenol
    • Terbutaline
  3. Long Acting beta 2 agonist for asthma?>
    Salmeterol
  4. Beta 1 and beta 2 agonist?
    Isoproterenol
  5. Phenylephrine?
    alpha 1 agonist--constriciton of bv,-->increase TPR-->increase BP
  6. alpha 1, beta 1, beta 2 agonist?
    epinephrine
  7. Low doses of epinephrine are selective for?
    beta1
  8. Norepinephrine is selective for what receptors?
    alpha 1 and alpha 2
  9. Metaprolol is what?
    Metaproterenol is what?
    • BB
    • Beta agonist
  10. What is the second messenger for a beta 2 agonist?
    camp via adenylyl cyclase which leads to relaxation of smooth muscle
  11. Rx for Bronchospasm?
    Prophylaxis
    • Beta 2 agonist
    • salmeterol
  12. Contraindications with beta 2 agonist for asthma Rx?
    arrythmias
  13. Adverse rxns caused by use of beta agonists for astham?
    • palpitation
    • headache
    • hypertension
    • anxiety
    • tremors
  14. IV drug used for acute attack of asthma?
    Theophylline
  15. MOA of Theophylline?
    inhibits phosphodiesterase-->high cAMP-->relaxation of smooth muscle
  16. WHy is theophylline not used widely?
    it has low TI
  17. Drugs that cause theophylline toxicity?
    drugs that decrease theophylline toxicity?
    • macrolides
    • quinolones--ciprofloxacin
    • and drugs that inhibit cyt p450

    • drugs that induce cyt p450 i.e
    • quininde
    • phenobarbital
    • rifampin
    • quinidine
    • barbituates
    • st. johns wart
    • phenytoin
    • griseofulvin
    • chronic etoh
  18. Theophylline is very sensitive to what enzyme activity?
    cyt p450
  19. Anticholinergic bronchodilator?
    atropine
  20. S/E of ipratropium?
    • mydriasis
    • anhydrosis
    • dry mouth
    • tachycadia
    • constipation
    • urinary retention
  21. DOC for bronchospasm caused by beta blocker?
    Ipratropium--anticholinergic
  22. What is the adjunct to albuterol in acute asthma in copd?
    ipratropium
  23. Inhaled corticosteroids for astham?
    • Triamcinolone
    • Flutacisone
    • Beclamethasone
  24. Oral corticosteroid for asthma?
    prednisolone
  25. MOA of corticosteroids in asthma?
    • 1. inhibit inflammatory molceules--kinin , histamine
    • 2 inhibit Leukotrienes--inhibit vaso and bronchoconstriction
  26. Indications for corticosteroids in respiratory conditons?
    • bronchial asthma
    • bronchial asthma
    • chronic bronchitis
  27. Adverse rnxs of corticosteroids for asthma?
    • Gi distress
    • Anorexia
    • fungal infections
  28. 2 LTD4 antagonists used for asthma?
    • Zafirlukast
    • Montelukast
  29. Lipooxygenase inhibitor>?
    Zileuton
  30. Drug used for prophylaxis and chronic treatment of asthma?
    Allergic rhinitis
    • Montelukast
    • Zafirleukast
  31. Which of the corticosteroidal drugs causes high LFTs?
    Zileuton
  32. adverse rxns of Montelukast,Zafirluekast?
    • rash
    • dental pain
    • headache
  33. 2 Mast cell stabilizers?
    • Cromolyn
    • Nedocromil
  34. MOA of mast cell stabilizers?
    inhibit release of histamine, Leukotrienes
  35. DOC for red eye associated with conjunctivits?
    • Cromolyn
    • Nedocromil
  36. Prophylactic for use in exercise induced asthma attack?
    • Cromolyn
    • Nedocromil
  37. S/E of Cromolyn
    Nedocromil?
    • myalgia
    • diarrhea
  38. Monoclonal antibody for asthma which binds to IgE on mast cells?
    Omalizumab
  39. S/E of Omalizumab?
    increased respiratory tract infections
  40. Management of acute asthma in young and old?
    beta 2 agonist--Albuterol
  41. Rx for asthma which occurs <2days/week or <2 nights/month?
    nothing
  42. Rx for asthma occuring >2days/week or >2nights/month?
    • Low dose inhaled beclamethasone
    • or
    • Montelukast
    • or
    • Cromolyn
  43. Rx of asthma which occurs daily or >1night a week?
    • low dose to medium dose beclamethasone
    • +
    • salmeterol/montelukast
  44. Rx of asthma which occurs daily and frequently at night?
    • high dose beclamethasone
    • +salmeterol/montelukast
    • + oral prednisone
  45. Rx of status asthmaticus?
    • oxygen
    • albuterol
    • IV methyl prednisone
    • nebuliazed ipratropium
    • if still not responding
    • IV or IM epinephrine
  46. Antitussive?
    Codein--stops cough reflex
  47. Nonopiod antitussive?
    dextromethorphan--no addictive/altered state properties
  48. What is given for exercise induced asthma before the activity?
    • Montelukast
    • Salmeterol
    • CROMOLYN****
  49. Expectorant?
    MOA?
    • Guinefesin
    • decrease mucus viscosity
  50. Contraindication for Guinfenesin?
    chronic cough due to smoking, emphysema, asthma
  51. How are diluents administered?
    ultrasonic nebulizer
  52. Mucolytic?
    used when?
    • n acetylcysteine
    • CF or atelectasis
  53. Recombinant DNAse used for CF?
    Dornase alfa
  54. 2 decongestants?
    MOA?
    • Pseudoephedrine
    • phenylephrine
    • vasoconstriction via alpha 1

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