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Short acting Beta 2 agonist for emergency management of asthma?
3 Short acting Beta 2 agonists used for asthma?
Long Acting beta 2 agonist for asthma?>
Beta 1 and beta 2 agonist?
alpha 1 agonist--constriciton of bv,-->increase TPR-->increase BP
alpha 1, beta 1, beta 2 agonist?
Low doses of epinephrine are selective for?
Norepinephrine is selective for what receptors?
alpha 1 and alpha 2
Metaprolol is what?
Metaproterenol is what?
What is the second messenger for a beta 2 agonist?
camp via adenylyl cyclase which leads to relaxation of smooth muscle
Rx for Bronchospasm?
Contraindications with beta 2 agonist for asthma Rx?
Adverse rxns caused by use of beta agonists for astham?
IV drug used for acute attack of asthma?
MOA of Theophylline?
inhibits phosphodiesterase-->high cAMP-->relaxation of smooth muscle
WHy is theophylline not used widely?
it has low TI
Drugs that cause theophylline toxicity?
drugs that decrease theophylline toxicity?
- and drugs that inhibit cyt p450
- drugs that induce cyt p450 i.e
- st. johns wart
- chronic etoh
Theophylline is very sensitive to what enzyme activity?
S/E of ipratropium?
- dry mouth
- urinary retention
DOC for bronchospasm caused by beta blocker?
What is the adjunct to albuterol in acute asthma in copd?
Inhaled corticosteroids for astham?
Oral corticosteroid for asthma?
MOA of corticosteroids in asthma?
- 1. inhibit inflammatory molceules--kinin , histamine
- 2 inhibit Leukotrienes--inhibit vaso and bronchoconstriction
Indications for corticosteroids in respiratory conditons?
- bronchial asthma
- bronchial asthma
- chronic bronchitis
Adverse rnxs of corticosteroids for asthma?
- Gi distress
- fungal infections
2 LTD4 antagonists used for asthma?
Drug used for prophylaxis and chronic treatment of asthma?
Which of the corticosteroidal drugs causes high LFTs?
adverse rxns of Montelukast,Zafirluekast?
MOA of mast cell stabilizers?
inhibit release of histamine, Leukotrienes
DOC for red eye associated with conjunctivits?
Prophylactic for use in exercise induced asthma attack?
S/E of Cromolyn
Monoclonal antibody for asthma which binds to IgE on mast cells?
S/E of Omalizumab?
increased respiratory tract infections
Management of acute asthma in young and old?
beta 2 agonist--Albuterol
Rx for asthma which occurs <2days/week or <2 nights/month?
Rx for asthma occuring >2days/week or >2nights/month?
- Low dose inhaled beclamethasone
Rx of asthma which occurs daily or >1night a week?
- low dose to medium dose beclamethasone
Rx of asthma which occurs daily and frequently at night?
- high dose beclamethasone
- + oral prednisone
Rx of status asthmaticus?
- IV methyl prednisone
- nebuliazed ipratropium
- if still not responding
- IV or IM epinephrine
Codein--stops cough reflex
dextromethorphan--no addictive/altered state properties
What is given for exercise induced asthma before the activity?
- decrease mucus viscosity
Contraindication for Guinfenesin?
chronic cough due to smoking, emphysema, asthma
How are diluents administered?
- n acetylcysteine
- CF or atelectasis
Recombinant DNAse used for CF?
- vasoconstriction via alpha 1