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When to schedule meds with antacids?
One hour before or two hours after
Antacids decrease absorption of which drugs
- quinolone abx
Population in need of high vitamin usage:
- rapid body growth
How and when to admin H2 blockers?
- With meals
- bedtime dose
- rapid IV (<2min)= cardiac dysrthy, hypotension
- Lansoprazole (PPI) (1)
- amoxicillin (2)
- clarithromycin (1)
- BID morning, evening
With prevpac, observe for?
- anaphylaxis, rash, or serum sickness like rxn
- signs of suprainfxn (candidiasis, c.diff)
- chk fecal occult, H/H
Antacids that contain __ cause diarrhea
- caution use in pt with ostomy, hemorrhoid, ulcerative colitis, diverticulitis
Antacids that contain___ cause constipation
- Al, Ca
- caution use in pt w/ hx of constipation, hemorrhoid
When to admin cholestryamine?
- Before meals
- Incr fluids: 2500mL
- Admin other drugs 1 hour before or 4-6 hours after
- Sprinkle powder on liquid/semiliquid
- HMG CoA reductase inhib
- decreases warfarin (chk INR)
- decreases absorption of propranolol, thiazide diuretics
Lovastatin Adverse effects
- acute kidney failure
- CATEGORY X
- antacids dec. statin
- incr digoxin
- horme contraceptive
- dc if transaminase 3xs normal
When is Lovastatin taken?
taken without regard to meals but must be taken consistently
When to admin omeprazole?
- immed. before meals, preferrably morning
- with antacid to decrease GI distress
Increases warfarin, inc INR
- decreases warfarin
Do NOT use with antacid, H2blocker, PPI
How to admin sucralfate?
- with water 1 hour before meal and at bedtime
- taken on empty stomach
- used in caution for pt w/ renal failure
- Inc warfarine
- dry mouth
- problem in older pt w/ renal insuff
- breast swelling/pain
- Rare: neutropenia, tachycardia, agranulocytosis
- prevention of NSAID induced gastric ulcer
- off label: chronic constipation, early pregnancy termination
- Pregnancy Category X
- Black Box warning
- stomach distress, diarrhea
Misoprostol ok with antacids except for
Mg containing antacids (diarrhea)
When to admin misoprostol?
With or after meals
- Hmg CoA increases rhabdomyolysis
- incr anticoag effect w/ warfarin