Card Set Information
Nucelotide Metabolism Biochem
Biochem test 4
Spingosine formed from...?
Histamine fromed from...?
Serotonin and Nicotinamine formed from...?
Thyroxine, Epinephrine, Tryptophan, 5,6-dihydroxyindole formed from...?
What are the two ways to synthesize nucleotides?
De Novo Pathway (from Scratch)
What is the salvage pathway?
Acivated ribose (PRPP) + base ---> Nucleotide
what is the de novo pathway?
activated ribose (PRPP) + amino acids and other things ---> nucleotides
Pyrimidine Ring De Novo Synthesis
Base made first then added to sugar and phosphate
Precursor for Pyrimidine base
CTP formed from?
Purine ring is...
Base is built on sugar
PRPP need for which De Novo pathway?
IMP leads to?
ATP and GTP which lead to dATP and dGTP respectively
Adenine +PRPP--->Adenylate PPi
adenine phosphoribosyl trasferase
Guanine + PRPP ---> guanylate + PPi
Hypoxanthine + PRPP ---> inosinate + PPi
Hypoanthine-guanine phosphoribosyltransferase (HGPRT)
Shortage of HGPRT leads to?
What is Lesch-Nyham Syndrome?
Chew on self!
HGPRT deficiency-->PRPP accumulation--.Stimulates purine base synthesis-->increase uric acid
Causes crippling gouty arthritis, sever neuropathy resulting in mental retardation, aggression, and self mutilation
Enzyme that converts A(G/C/U)DP to dA(G/C/U)DP?
Two enzymes targeted by Anti-cancer drugs?
Suicide inhibitor prevents dUMP to TMP
Aminopterin and Metotrexate
Competitive inhibitors that compete to get dihydrofolate
ATCase whitle ATP stimulates it
PRPP inhibited before and after by?
IMP, AMP, and GMP
AMP inhibits and stimulates?
Inhibites IMP to Adenylosuccinate
GMP inhibits and stimulates?
GMP inhibits IMP to Xanthylate
Ribonucleotide reducates inhibited by?
TTP inhibits self and CTP production and encourages production of?
purines by stimulating GTP
Build up of uric acid in joints
needle shaped sodium urate cyrstals
Caused by renal failure lack of HGPRT or G-6_P deficiency
Treated with allopurinol (inhibits xanthione oxidase, less uric acid accumulation)
SCID (sever combined immunodeficiency syndrome)
Adenosine deaminase deficiency
no antibodies or T cells
Treated with bone marrow transplant and gene therapy