Quiz 8 - Phar 605

Card Set Information

Author:
VASUpharm14
ID:
116670
Filename:
Quiz 8 - Phar 605
Updated:
2011-12-20 17:15:22
Tags:
im too cool
Folders:

Description:
Top 141-160
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user VASUpharm14 on FreezingBlue Flashcards. What would you like to do?


  1. Pravachol
    generic?
    pravastatin sodium
  2. Pravachol
    class?
    antihyperlipidemic
  3. Pravachol
    MOA?
    a specific inhibitor of HMG-CoA reductase. This enzyme is responsible for the conversion of HMG-CoA to mevalonate, an early rate inhibiting step in the synthesis of cholesterol. In therapeutic concentrations, HMG-CoA reductase is not completely blocked, allowing biologically necessary amounts of mevalonate to be produced. Pravachol reduces both normal and elevated LDL (low density lipoprotein) concentrations. It moderately reduces triglyceride and VLDL (very low density lipoprotein) concentrations. It is not known whether Pravachol's therapeutic effect is due to an increased LDL catabolism, a decrease in VLDL (a precursor to LDL), or a direct decrease in LDL production. In addition to LDL reduction, Pravachol moderately increases HDL (high density lipoprotein) concentrations. High LDL and low HDL levels have been shown to be risk factors in coronary heart disease.
  4. Pravachol
    dosage form?
    Tablets
  5. Tessalon
    generic?
    benzonatate
  6. Tessalon
    class?
    antitussive
  7. Tessalon
    MOA?
    acts peripherally by anesthetizing the stretch receptors located in the respiratory passages, lungs, and pleura by dampening their activity and thereby reducing the cough reflex at its source.
  8. Tessalon
    dosage form?
    Capsules (Perles)
  9. Novolog
    generic?
    insulin aspart, rDNA origin
  10. Novolog
    class?
    antidiabetic
  11. Novolog
    MOA?
    Insulin is the primary hormone responsible for carrying out proper glucose utilization in metabolic processes. In adipose and muscle tissue, insulin activates specific enzymes, promotes the transport of monosaccharides (including glucose) across cell membranes and facilitates the transformation of intracellular amino acids into proteins. Insulin also decreases the formation of triglycerides. Insulin aspart is synthesized by recombinant DNA using Saccharomyces cerevisiae (baker's yeast). The difference between insulin aspart and human insulin is the substitution of proline with aspartic acid at the B28 position.
  12. Novolog
    dosage form?
    • Novolog: 100 units of insulin aspart per mL
    • Novolog Mix 70/30: 30% insulin aspart solution and 70% insulin aspart protamine suspension
  13. Paxil
    generic?
    paroxetine hydrochloride
  14. Paxil
    class?
    antidepressant
  15. Paxil
    MOA?
    highly selective inhibitor of neuronal serotonin uptake. It weakly inhibits norepinephrine and dopamine neuronal reuptake.
  16. Paxil
    dosage form?
    • Tablets (regular, controlled-release)
    • Oral suspension
  17. Paxil XR
    generic?
    paroxetine hydrochloride
  18. Paxil XR
    class?
    antidepressant
  19. Paxil XR
    MOA?
    highly selective inhibitor of neuronal serotonin uptake. It weakly inhibits norepinephrine and dopamine neuronal reuptake.
  20. Paxil XR
    dosage form?
    • Tablets (regular, controlled-release)
    • Oral suspension
  21. Pexeva
    generic?
    paroxetine hydrochloride
  22. Pexeva
    class?
    antidepressant
  23. Pexeva
    MOA?
    highly selective inhibitor of neuronal serotonin uptake. It weakly inhibits norepinephrine and dopamine neuronal reuptake.
  24. Pexeva
    dosage form?
    • Tablets (regular, controlled-release)
    • Oral suspension
  25. Phenergan with codeine
    generic?
    promethazine hydrochloride with codeine phosphate
  26. Phenergan with codeine
    class?
    antitussive
  27. Phenergan with codeine
    MOA?
    competitively inhibits histamine at the H1 receptor site causing a spasmolytic and decongestant effect. Antihistimines will prevent, but not reverse, histamine mediated reactions. Codeine depresses the cough reflex center in the medulla oblongota.
  28. Phenergan with codeine
    dosage form?
    Syrup (5 mL)
  29. Avelox
    generic?
    moxifloxacin hydrochloride
  30. Avelox
    class?
    fluoroquinolone antibiotic
  31. Avelox
    MOA?
    exerts its antibacterial actions by preventing the synthesis of bacterial DNA through inhibition of the enzyme DNA gyrase and topoisomerase IV. Wide range of gram-negative and gram-positive bacteria, including H. influenzae, M. catarrhalis, S. pneumoniae, S. aureus, H. parainfluenxae, M. pneumonia, S. pyogenes, K. pneumoniae, and C. pneumonia.
  32. Avelox
    dosage form?
    • Tablets
    • Injection (premix)
  33. Zanaflex
    generic?
    tizanidine hydrochloride
  34. Zanaflex
    class?
    muscle relaxant
  35. Zanaflex
    MOA?
    an agonist at alpha-2-adrenergic receptor sites and presumably reduces spasticity by increasing presynpatic inhibition of motor neurons. Does not affect skeletal muscle fibers or the neuromuscular junction with minimal effects on monosynaptic spinal reflexes. Its greatest effects are on polysynaptic pathways. Structurally, tizanidine is similar to clonidine but with much lower effects on blood pressure.
  36. Zanaflex
    dosage form?
    • Tablets
    • Capsules
    • *formulations are not AB-rated equivalents.
  37. Catapres
    generic?
    clonidine hydrochloride
  38. Catapres
    class?
    antihypertensive
  39. Catapres
    MOA?
    stimulates alpha-adrenergic receptors resulting in inhibition of bulbar sympathetic cardioaccelerator and sympathetic vasoconstrictor centers. This results in reduced sympathetic outflow from the CNS and a decrease in peripheral resistance, renal vascular resistance, heart rate, and blood pressure.
  40. Catapres
    dosage form?
    Tablets
  41. Catapres TTS
    generic?
    clonidine hydrochloride
  42. Catapres TTS
    class?
    antihypertensive
  43. Catapres TTS
    MOA?
    stimulates alpha-adrenergic receptors resulting in inhibition of bulbar sympathetic cardioaccelerator and sympathetic vasoconstrictor centers. This results in reduced sympathetic outflow from the CNS and a decrease in peripheral resistance, renal vascular resistance, heart rate, and blood pressure.
  44. Catapres TTS
    dosage form?
    Transdermal Extended Release Patches (1, 2, 3)
  45. Nexiclon XR
    generic?
    clonidine hydrochloride
  46. Nexiclon XR
    class?
    antihypertensive
  47. Nexiclon XR
    MOA?
    stimulates alpha-adrenergic receptors resulting in inhibition of bulbar sympathetic cardioaccelerator and sympathetic vasoconstrictor centers. This results in reduced sympathetic outflow from the CNS and a decrease in peripheral resistance, renal vascular resistance, heart rate, and blood pressure.
  48. Nexiclon XR
    dosage form?
    Tablets (Extended-release)
  49. MS Contin
    generic?
    morphine sulfate (extended release)
  50. MS Contin
    class?
    opioid analgesic
  51. MS Contin
    MOA?
    produces analgesia by a central action on the central opiate receptors. Following oral administration of a given dose of morphine, the amount ultimately absorbed is essentially the same whether the source is MS Contin or a conventional formulation. Morphine is released from MS Contin somwhat more slowly than from conventional oral preparations.
  52. MS Contin
    dosage form?
    Tablets
  53. Inderal (LA)
    generic?
    propranolol hydrochloride
  54. Inderal (LA)
    class?
    antihypertensive
  55. Inderal (LA)
    MOA?
    non-selective blockage of beta-adrenergic receptors resulting in (1) a decreased heart rate and cardiac output, (2) a decrease in systolic and diastolic blood pressure, (3) an inhibition of isoproterenol tachycardia, and (4) a decrease of reflex orthostatic tachycardia. Propranolol crosses the blood brain barrier.
  56. Inderal (LA)
    dosage form?
    • Tablets
    • Capsules, sustained release (LA/XL)
    • Injection
    • Solution
  57. Innopran XL
    generic?
    propranolol hydrochloride
  58. Innopran XL
    class?
    antihypertensive
  59. Innopran XL
    MOA?
    non-selective blockage of beta-adrenergic receptors resulting in (1) a decreased heart rate and cardiac output, (2) a decrease in systolic and diastolic blood pressure, (3) an inhibition of isoproterenol tachycardia, and (4) a decrease of reflex orthostatic tachycardia. Propranolol crosses the blood brain barrier.
  60. Innopran XL
    dosage form?
    • Tablets
    • Capsules, sustained release (LA/XL)
    • Injection
    • Solution
  61. Provigil
    generic?
    modafinil
  62. Provigil
    class?
    pseudosympathomimetic
  63. Provigil
    MOA?
    exact mechanism of action of modafinil is unknown. It has weak to no affinity for receptors for norepinephrine, serotonin, dopamine, GABA, adenosine, histamine-3, melatonin, and benzodiazepines. Does bind to the dopamine transporter and inhibits dopamine reuptake in some regions of the brain. However, effectiveness of modafinil is not inhbited by the dopamine receptor antagonist haloperidol.
  64. Provigil
    dosage form?
    Tablets
  65. Antivert
    generic?
    meclizine hydrochloride
  66. Antivert
    class?
    antivertigo agent
  67. Antivert
    MOA?
    blocks histamine (H1) receptors in the central nervous system. This action may depress teh vestibular apparatus, the chemoreceptor trigger zone, and/or the vomiting center in the CNS. Blockage of acetylcholine at postganglionic muscarinic receptors may contribute to its pharmacologic effects.
  68. Antivert
    dosage form?
    Tablets (regular, chewable)
  69. Atarax
    generic?
    hydroxyzine hydrochloride
  70. Atarax
    class?
    antiallergy agent
  71. Atarax
    MOA?
    antagonizes the H1 (histamine) receptors in peripheral tissues. It may also suppress histamine activity in the subcortical region of the CNS.
  72. Atarax
    dosage form?
    • Tablets
    • Syrup
    • Injection
  73. Nasacort AQ
    generic?
    triamcinolone acetonide (intranasal)
  74. Nasacort AQ
    class?
    antiallergy agent
  75. Nasacort AQ
    MOA?
    reduces the accumulation of surface basophilic cells resulting in a localized anti-inflammatory effect.
  76. Nasacort AQ
    dosage form?
    Suspension
  77. Ditropan
    generic?
    oxybutynin chloride (oral)
  78. Ditropan
    class?
    urinary bladder modifier
  79. Ditropan
    MOA?
    inhibits muscarinic action of acetylcholine on smooth muscle. Blockage does not occur at skeletal neuromuscular junctions or autonomic ganglia. Oxybutynin chloride relaxes bladder smooth muscle which decreases urgency, frequency, urinary leakage, and dysuria.
  80. Ditropan
    dosage form?
    • Tablets
    • Syrup
    • *also available in a topical patch formulation
  81. Ditropan XL
    generic?
    oxybutynin chloride (oral)
  82. Ditropan XL
    class?
    urinary bladder modifier
  83. Ditropan XL
    MOA?
    inhibits muscarinic action of acetylcholine on smooth muscle. Blockage does not occur at skeletal neuromuscular junctions or autonomic ganglia. Oxybutynin chloride relaxes bladder smooth muscle which decreases urgency, frequency, urinary leakage, and dysuria.
  84. Ditropan XL
    dosage form?
    • Tablets (extended-release)
    • Syrup
    • *also available in a topical patch formulation
  85. Lomotil
    generic?
    diphenoxylate hydrochloride with atropine sulfate
  86. Lomotil
    class?
    antidiarrheal
  87. Lomotil
    MOA?
    binds to intestinal opiate receptors decreasing peristalsis and affecting water and electrolyte movement through the lower intestine. These actions are due to effects on the circular and longitudinal muscles of the intestine. Atropine sulfate is included to discourage deliberate abuse and overdosage. Atropine has antimuscarinic activity which may add to the therapeutic effects of Lomotil.
  88. Lomotil
    dosage form?
    • Tablets
    • Liquid (per 5 mL)
  89. Lidex
    generic?
    fluocinonide (topical)
  90. Lidex
    class?
    topical anti-inflammatory
  91. Lidex
    MOA?
    adrenocorticoids bind to certain receptor proteins found in the cytoplasm of sensitive cells to form a steroid-receptor complex. This steroid-receptor complex enters the nucleus of the cell where it reacts with chromatin, or DNA. The steroid, or possibly the receptor, then uses stored information to stimulate, or in some cases inhibit, the transcription of m-RNA. The stimulation of m-RNA results in the synthesis of specific enzymes that carry out its antiallergy and anti-inflammatory actions.
  92. Lidex
    dosage form?
    • Ointment
    • Gel, water miscible
    • Cream, water miscible
    • Solution
  93. Xopenex
    generic?
    levalbuterol hydrochloride
  94. Xopenex
    class?
    antiasthmatic
  95. Xopenex
    MOA?
    a sympathomimetic which stimulates adenyl cyclase, the enzyme which catalyzes the formation of c-AMP (cyclic 3'5' adenosine monophosphate) from ATP (adenosine triphosphate). This formation causes relaxation of bronchial, uterine, and vascular smooth muscle through stimulation of beta-2-adrenergic receptors. Levalbuterol has approximately 2-fold greater binding affinity to beta-adrenergic receptors than racemic albuterol.
  96. Xopenex
    dosage form?
    • Solution for inhalation
    • Xopenex HFA
  97. Humalog
    generic?
    insulin lispro, rDNA origin
  98. Humalog
    class?
    antidiabetic
  99. Humalog
    MOA?
    Insulin is the primary hormone responsible for carrying out proper glucose utilization in metabolic processes. In adipose and muscle tissue, insulin activates specific enzymes, promotes the transport of monosaccharides (including glucose) across cell membranes and facilitates the transformation fo intracellular amino acids into proteins. Inuslin also decreases the formation of triglycerides. Insulin lispro is synthesized in a non-pathogenic strain of E. coli that has been genetically altered by the addition of the gene for insulin lispro. The only difference between insulin lispro and human insulin is the reversal of the amino acids at the 28 and 29 positions on the B-chain.
  100. Humalog
    dosage form?
    • Humalog: 100 units of insulin lispro per mL
    • Humalog Mix 75/25: 25% insulin lispro solution and 75% insulin lispro protamine suspension
    • Humalog Mix 50/50: 50% insulin lispro solution and 50% insulin lispro protamine suspension
  101. Flagyl
    generic?
    metronidazole
  102. Flagyl
    class?
    antibacterial/antiprotozoal
  103. Flagyl
    MOA?
    metronidazole is reduced by electron-transport proteins of susceptible bacteria to unstable intermediate compounds which bind to DNA causing DNA strand breakage and cell death. Distribution occurs to most body fluids including cerebrospinal fluid, saliva, and breast milk.
  104. Flagyl
    dosage form?
    • Tablets
    • Capsules
    • Extended Release Tablets (Flagyl ER)
    • Injection, Flagyl IV RTU
    • *also available in topical and vaginal preparations

What would you like to do?

Home > Flashcards > Print Preview