Antrax

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Author:
ehamm
ID:
116802
Filename:
Antrax
Updated:
2011-11-14 19:24:50
Tags:
Antrax
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Description:
Antrax
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  1. Organism
    • B. Anthracis
    • D-glutamix acid capsule has anti-phagocytic properties
    • Exotoxin producer
  2. Epidemiology
    • Associated with Herbivores
    • Infection through contact with animals/products
    • Spore transmission
    • Skin or inhalation
  3. Pathogenesis
    • Spores multiple in vegetative state
    • Large production of exotoxins
    • Immunity: Mechanisms not known
  4. Manifestations
    • Cutaneous: 2-5 days post exposure; erythematous papule -> vesicular and ulcerative stage over 7-10 days to form black scab with edema; self limiting
    • Pulmonary: 1-5 days of non-specific malaise, mild fever, and nonproductive cough -> progressive respiratory distress and cyanosis; massive edema in neck/chest/mediastinum; rapid progression to death
  5. Treatment
    • Antimicrobial treatment prevents dissemination
    • Penicillin
    • Doxy, cipro used for prophylaxis
    • Prevention: vaccine available, efficacy uncertain

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