Ketogenesis

Card Set Information

Author:
jaguavai
ID:
117346
Filename:
Ketogenesis
Updated:
2011-11-16 19:35:37
Tags:
Pharm 412 Roseman 2014
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Description:
Ketogenesis steps etc.
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  1. Process
    
  2. Step 1
    • 2 x acetyl CoA to acetoacetyl-CoA using thiolase
    • reversal of final step of beta oxidation
  3. Step 2
    • Acetoacetyl-CoA to HMG-CoA through HMG-CoA synthase.
    • Requires additional Acethyl-CoA and H20
  4. Step 3
    • HMG CoA to Acetoacetate through HMG-CoA lyase
    • Produces acetyl-CoA
  5. Step 4
    • Acetoacetate to acetone through acetoacetate decarboxylase (removal of CO2)
    • OR Acetoacetate to Beta hydroxybutyrate through beta-hydroxybutyrate dehydrogenase (NAD -> NADH)
  6. Ketone bodies as fuel

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