Fatty Acid Synthesis

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Author:
jaguavai
ID:
117362
Filename:
Fatty Acid Synthesis
Updated:
2011-11-16 19:41:17
Tags:
Pharm 412 Roseman 2014
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Description:
Fatty Acid Synthesis
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  1. Steps in one cycle (5)
    • 1) condensation
    • 2) reduction of beta-keto group
    • 3) dehydration
    • 4) reduction of double bond
    • 5) translocation of butyryl group to KS
  2. Step 1 (Condensation)
    • CO2 from malonyl-CoA is lost
    • Acetyl from KS hooks to residue on ACP
  3. Step 2 (reduction of beta-keto group
    • C=O on beta carbon reduced
    • Converts NADPH to NADP
  4. Step 3 (dehydration)
    • H2O removed from beta carbon
    • Double bond formed between alpha and beta carbons
  5. Step 4 (reduction of double bond)
    • Double bond between alpha and beta is reduced
    • NADPH to NADP
  6. Step 5 (translocation)
    Chain moved from ACP to KS
  7. What happens after translocation?
    Another malonyl-CoA attaches to ACP

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