Antidiabetic drugs

Card Set Information

Author:
jaguavai
ID:
117500
Filename:
Antidiabetic drugs
Updated:
2011-11-17 11:17:29
Tags:
Pharm 412 Roseman 2014
Folders:

Description:
Antidiabetic drugs, classes, MOA's and ADR's
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user jaguavai on FreezingBlue Flashcards. What would you like to do?


  1. Classes (6)
    • Insulin Secretagogues (sulfonylureas & meglitanides)
    • Thiazolidinediones (TZD's)
    • Biguanide
    • aplha-Glucosidase Inhibitors
    • DPP-IV Inhibitors
    • Hormone mimetics
  2. Sulfonylurea drugs (3)
    • Glyburide
    • Glipizide
    • Glimipride
  3. Meglitanides (2)
    • Repaglinide
    • Nateglinide
  4. Sulfonylurea MOA
    • Bind to ATP-sensitive K channel receptors, causing depolarization of cell.
    • Ca ion influx through voltage-gated channels causes secretion of insulin
  5. Meglitanide MOA
    • Interact with ATP-sensitive K channel on pancreatic Beta cells
    • Depolarization of the cell opens Ca channels, Ca influx and insulin secretion
    • (similar to sulfonylurea)
  6. Sulfonylurea ADR
    Tachyphylaxis
  7. Insulin Secretagogue ADR's (sulfonylurea & meglitanides)
    • Hypoglycemia due to promotion of insulin secretion
    • Weight gain due to insulin secretion
  8. Thiazolidinedione (TZD) Drugs (2)
    • Rosiglitazone
    • Pioglitazone
  9. TZD MOA
    Improves insulin sensitivity in adipose, skeletal muscle and liver
  10. Selected TZD ADR's (2)
    • Cardiotoxicity (Avandia)
    • Hepatotoxicity
  11. Biguanide Drug (1)
    Metformin
  12. Biguanide MOA (3)
    • Decreased hepatic gluconeogenesis
    • Decreases intestinal absorption of glucose
    • Improves insulin sensitivity by increasing peripheral glucose uptake and utilization
  13. Selected Biguanide ADR's (4)
    • Lactic acidosis (black box warning)
    • Renally eliminated, contraindicated w/renal issues
    • Contraindicated for those that may become hypoxic (COPD)
    • Diarrhea (>50%)
  14. alpha-Glucosidase Inhibitor Drugs (2)
    • Acarbose (Precose)
    • Miglitol (Glyset)
  15. alpha-Glucosidase MOA (2)
    • Delay digestion and absorption of carbohydrates into absorbable monosaccharides by competetively inhibiting alpha-glucosidase enxzymes in the intesting
    • Cause a slower rise in post-prandial blood glucose, requiring reduced insulin response (insulin sparing agents)
  16. Selected alpha-Glucosidase Inhibitor ADR's (3)
    • Flatulance
    • Diarrhea
    • Abdominal pain
  17. DPP-IV Inhibitor Drugs (3)
    • Linagliptin
    • Sitagliptin
    • Saxagliptin
  18. DPP-IV inhibitor MOA (3)
    • Increase glucose-dependent insulin secretion
    • Decrease Glucagon levels
    • Slow gastir emptying by preventing degredation on incretin hormones by DPP-IV
  19. DPP-IV ADR
    None
  20. Hormone Mimetic Drugs (3)
    • Exenatide
    • Liraglutide
    • Pramlintide
  21. Hormone Mimetic MOA (4)
    • Increase glucose-dependent insulin secretion
    • Decrease glucagon levels
    • Slow gastric emptying
    • Decrease appetite
  22. Selected Hormone Mimetic ADR's (3)
    • Exanatide - weight loss and nausea
    • Liraglutide - nausea and risk of thyroid cancer
    • Pramlintide - nausea and hypoglycemia

What would you like to do?

Home > Flashcards > Print Preview